Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 43 (12 Aug 2020)
Sequence version 1 (05 Oct 2010)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Ankyrin Repeat Transient Receptor Potential Channel

Gene

Esi_0019_0113

Organism
Ectocarpus siliculosus (Brown alga) (Conferva siliculosa)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.4.3.4, the transient receptor potential ca(2+) channel (trp-cc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin Repeat Transient Receptor Potential ChannelImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:Esi_0019_0113Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEctocarpus siliculosus (Brown alga) (Conferva siliculosa)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri2880 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarStramenopilesOchrophytaPX cladePhaeophyceaeEctocarpalesEctocarpaceaeEctocarpus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002630 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome LG25

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei884 – 903HelicalSequence analysisAdd BLAST20
Transmembranei978 – 1001HelicalSequence analysisAdd BLAST24
Transmembranei1013 – 1034HelicalSequence analysisAdd BLAST22
Transmembranei1055 – 1077HelicalSequence analysisAdd BLAST23
Transmembranei1145 – 1167HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
2880.D8LH97

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini887 – 1178Ion_transInterPro annotationAdd BLAST292

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni797 – 819DisorderedSequence analysisAdd BLAST23

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3614, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D8LH97

Database of Orthologous Groups

More...
OrthoDBi
559278at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036770, Ankyrin_rpt-contain_sf
IPR005821, Ion_trans_dom
IPR002153, TRPC_channel

The PANTHER Classification System

More...
PANTHERi
PTHR10117, PTHR10117, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520, Ion_trans, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D8LH97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARCTLICAA LDKATSDADM ADAAMPEVHQ QSWTPHRAQN LLGEDLESVL
60 70 80 90 100
DGALQSKAPE DGQNLLTYAA AQGRDAWFLF IAGKIRSKMG VRALAKELRE
110 120 130 140 150
LDIDRAPLLF NAAASRGEKS CFRTAHDLVY KALGKGGLLE QLGAVDGEGR
160 170 180 190 200
TMLMHAARSN NSDAYDEIVG IYFKVVPLTS SGYTEKDHKG MNCLHHAAEA
210 220 230 240 250
GCSEVLGKVI KKYSDAGGSS YAERDNNNRT PVMCVLSDAS REERADDSLR
260 270 280 290 300
DKFTLLYSNM STTCGEQDEK VCTHDGGHAK QGWMEMTDVP TQQISRSEEI
310 320 330 340 350
SKARGVTELM HAARGGLVSL ELALNEPLPS SRLEDGSISL DGALNVEACD
360 370 380 390 400
EPASDEPRWE PQPAWGKGLL LAAAAERGDI DVLHVVLTAI KDNKFTKEPN
410 420 430 440 450
TDRFTLRKQE SRLAELPYGD GEKVRTVVRE MSKGGKSLFS EAILSGQTVA
460 470 480 490 500
VKHVYRLIVK LFGKTHPETW AILTGRDFNS GKVAEASPLA CAASASMEPC
510 520 530 540 550
DHGRDTFDLV YSYLQTHAPD EKKLRIQLVP QPPPLDLTAK TQISPLVGAA
560 570 580 590 600
FSSNWILFWR VYDTYTTLAK KPWLRTNALR RATSDKSGGE ELMSWREYLR
610 620 630 640 650
AYSSRAVHVA SERGAFTDLR DLVKEGFPLH DDHIPALLVS IGDHEQDIIE
660 670 680 690 700
TVLFAVANAS NPFGMAAGVS RFLRRARVDH PMHQRGLRRL QTRIDRFTLE
710 720 730 740 750
QWMLEPSLLV EKINKAKKYR GPVYKDPLQS ALDRGSDALE FLFSPLVLDY
760 770 780 790 800
VHVKFAGTLP HWSSRNPFQP TINEGLYKYD NFEVYDLAKL LRGSKNDQAT
810 820 830 840 850
GRTAPSGASS ASTGSTNRGS FLWRSPGSIM SFLLRFLQGW DHPRSNDQSV
860 870 880 890 900
WSIPHLTILP GLQFSLAGIL GKPETFFKVP VIRFVYEIFS YLVMLVLFCS
910 920 930 940 950
SVLLKEPDFI PRDEVIFYIF AAGLLWREVL EFLDGVPTRR HRTSGGPRTE
960 970 980 990 1000
EGGRVEPGIS HLGAGSNFNR MVSAFTRYVF YDTWNFMDTS TICCIFVAFI
1010 1020 1030 1040 1050
FRMIARFDSE FDLFYAQFFY ALSAPLLFSR LLVLSQIDAT LGPMTQVIWR
1060 1070 1080 1090 1100
MMSHMLRFSA FIAMVMLSFA LAFHAVFHTC GEHSEPQCTL DDDDAFPLRD
1110 1120 1130 1140 1150
AFGTFGDSLL TVFSSALGGP EFDLFDDAGS DCRCNLPRGA RSAGISMMVV
1160 1170 1180 1190 1200
YTITMSVVLL NLLIAVLSTA HDEVYVNAEK EFHLARARLV VQSARSVAHR
1210 1220 1230 1240
RPPPPLNLVK LGFGVLIDVF TEIWRFILWA RSLRSRCLDW
Length:1,240
Mass (Da):138,168
Last modified:October 5, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i858790B518DC9335
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FN648364 Genomic DNA Translation: CBN74316.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CBN74316; CBN74316; Esi_0019_0113

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN648364 Genomic DNA Translation: CBN74316.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi2880.D8LH97

Protein family/group databases

TCDBi1.A.4.3.4, the transient receptor potential ca(2+) channel (trp-cc) family

Genome annotation databases

EnsemblProtistsiCBN74316; CBN74316; Esi_0019_0113

Phylogenomic databases

eggNOGiKOG3614, Eukaryota
InParanoidiD8LH97
OrthoDBi559278at2759

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR036770, Ankyrin_rpt-contain_sf
IPR005821, Ion_trans_dom
IPR002153, TRPC_channel
PANTHERiPTHR10117, PTHR10117, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD8LH97_ECTSI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D8LH97
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: August 12, 2020
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again