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Protein
Submitted name:

Polyprotein

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteaseUniRule annotation, Hydrolase, Multifunctional enzymeSAAS annotation, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
PolyproteinImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 121Peptidase A2InterPro annotationAdd BLAST70
Domaini175 – 365Reverse transcriptaseInterPro annotationAdd BLAST191

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.UniRule annotation

Family and domain databases

CDDicd05482 HIV_retropepsin_like, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR001969 Aspartic_peptidase_AS
IPR001995 Peptidase_A2_cat
IPR021109 Peptidase_aspartic_dom_sf
IPR034170 Retropepsin-like_cat_dom
IPR018061 Retropepsins
IPR000477 RT_dom
IPR010659 RVT_connect
IPR010661 RVT_thumb
PfamiView protein in Pfam
PF00077 RVP, 1 hit
PF00078 RVT_1, 1 hit
PF06815 RVT_connect, 1 hit
PF06817 RVT_thumb, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS50175 ASP_PROT_RETROV, 1 hit
PS00141 ASP_PROTEASE, 1 hit
PS50878 RT_POL, 1 hit

Sequencei

Sequence statusi: Fragment.

D8LA67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
TRTNSPTGRE LQVRGDNPRS EAGAEGQGTF NFPQITLWQR PLVSIKVGGQ
60 70 80 90 100
IKEALLDTGA DDTVLEEISL PGKWKPKMIG GIGGFIKVRQ YDQIPIEICG
110 120 130 140 150
KKAIGTVLVG PTPVNIIGRN XLTQLGCTLN FPISPIETVP VKLKPGMDGP
160 170 180 190 200
KVKQWPLSEE KIKALTAICE EMEKEGKITK IGPENPYNTP IFAIKKKDST
210 220 230 240 250
KWRKLVDFRE LNKRTQDFWE VQLGIPHPAG LKKKKSVTVL DVGDAYFSVP
260 270 280 290 300
LDETFRKYTA FTIPSINNAT PGIRYQYNVL PQGWKGSPAI FQSSMTKILE
310 320 330 340 350
PFRTKNPDIV IYQYMDDLYV GSDLEIEQHR AKIEELRGHL LKWGFTTPDK
360 370 380 390 400
KHQKEPPFLW MGYELHPDKW TVQPIQLPAK ESWTVNDIQK LVGKLNWASQ
410 420 430 440 450
IYPGIKVKQL CKLLRGTKAL TDIVPLTEEA ELELAENREI LKEPVHGVYY
460 470 480 490 500
DPSKDLIAEI QKQGQDQWTY QIYQEPFKNL KTGKYAKRRA AHSNDVKQLA
510 520 530 540 550
EAVQKITMES IVIWGKTPKF RLPIQKETWE TWWTDYWQAT WIPEWEFVNT
560
PPLVKLWYQL EKEPIVE
Length:567
Mass (Da):64,936
Last modified:October 5, 2010 - v1
Checksum:iAC222E44BF4CAE48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei567Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN599737 Genomic DNA Translation: CBI68514.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN599737 Genomic DNA Translation: CBI68514.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd05482 HIV_retropepsin_like, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR001969 Aspartic_peptidase_AS
IPR001995 Peptidase_A2_cat
IPR021109 Peptidase_aspartic_dom_sf
IPR034170 Retropepsin-like_cat_dom
IPR018061 Retropepsins
IPR000477 RT_dom
IPR010659 RVT_connect
IPR010661 RVT_thumb
PfamiView protein in Pfam
PF00077 RVP, 1 hit
PF00078 RVT_1, 1 hit
PF06815 RVT_connect, 1 hit
PF06817 RVT_thumb, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS50175 ASP_PROT_RETROV, 1 hit
PS00141 ASP_PROTEASE, 1 hit
PS50878 RT_POL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD8LA67_9HIV1
AccessioniPrimary (citable) accession number: D8LA67
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: July 18, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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