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Entry version 47 (11 Dec 2019)
Sequence version 1 (05 Oct 2010)
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Protein
Submitted name:

Acriflavin resistance protein

Gene

Hden_0937

Organism
Hyphomicrobium denitrificans (strain ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
HDEN582899:G1GLW-929-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Acriflavin resistance proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Hden_0937Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHyphomicrobium denitrificans (strain ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri582899 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaeHyphomicrobium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002033 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei334 – 353HelicalSequence analysisAdd BLAST20
Transmembranei360 – 384HelicalSequence analysisAdd BLAST25
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Transmembranei463 – 481HelicalSequence analysisAdd BLAST19
Transmembranei529 – 548HelicalSequence analysisAdd BLAST20
Transmembranei860 – 877HelicalSequence analysisAdd BLAST18
Transmembranei910 – 935HelicalSequence analysisAdd BLAST26
Transmembranei955 – 976HelicalSequence analysisAdd BLAST22
Transmembranei988 – 1013HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
582899.Hden_0937

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1024 – 1055DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1041 – 1055PolyampholyteSequence analysisAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG4105BZS Bacteria
COG0841 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000158127

KEGG Orthology (KO)

More...
KOi
K07788

Identification of Orthologs from Complete Genome Data

More...
OMAi
FIIPCFY

Database of Orthologous Groups

More...
OrthoDBi
145346at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.2090.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R

The PANTHER Classification System

More...
PANTHERi
PTHR32063 PTHR32063, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00873 ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00702 ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82714 SSF82714, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D8JUG1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVSRPFIER PIATTLLALA TILGGILGYL SLPISSLPQV DFPTVEVTTE
60 70 80 90 100
LPGASPETMA TLITASLERQ FGQIQSLATM SSTSSFGLSR ITLQFNLDRD
110 120 130 140 150
IDSAAQDVQA AINAAGSTLP KNLPYPPVYS KVNPADTPIV TLALTSDTLS
160 170 180 190 200
LRSLSDLADT LLAQRLSSVS GVGHVSIEGG IKPAVRVEAD IRRLASYGLS
210 220 230 240 250
MADLSSAISA ANVAGPKGSL DGDKQSFVIA SNDQISDAKA YNDVIIAYRN
260 270 280 290 300
EAPVRVKDVA KVSDGLENTR VGGWYQGKPA VIVDIQRQPG ANVIDTVTRI
310 320 330 340 350
KNELPRVERT MPAGVNLQIV SDRTGTIRAS VHDVQFTLVL SVGLVVMVVL
360 370 380 390 400
LFLRSLRATI IAGVALPVSL IATFGVMYFC GFSVDNLSLM ALTIGTGFVV
410 420 430 440 450
DDAIVMIENV VRHLEKGEKP MKAALDGARE IGFTVISLTL SLIAVFIPLL
460 470 480 490 500
FMTGLVGRMF REFALTLTIA VVVSAVVSLT LTPMMCARLL KGDHDENGTR
510 520 530 540 550
LGRLFGDFMD RVILGYKHTL EFVLRHQPAT LFVALLTVVL TIWLYVIMPK
560 570 580 590 600
GFLPDQDTGA ITAVVEGGPQ ISFNEISRLQ NDVAQIIARD PDVSGVASIV
610 620 630 640 650
GIGQLNATQN VGNLKILLKP RAEREANVTE VIQRLKQEVK SVVGTTVHLQ
660 670 680 690 700
PVQDVQISTQ SSRARYQYTL VSTDAAEVAE WSKRLADALK ASPYLRDVSS
710 720 730 740 750
EEVEGGLIAK ISVDRVLAGR LGVTMAAIND ALSNAFGQRQ VSTIYQQSNQ
760 770 780 790 800
YRVVLEAAPE YRSDPSRLNR LYVPSSTTGT QVLLTSVASM TYETAPLAIS
810 820 830 840 850
HQDQFPSTTL SFNLAPNASL SDALHAIDTA QKEVSLPATV NGTFYGDAAE
860 870 880 890 900
FTKSLQGQPW LILAAIVTIY IVLGVLYESL IHPFTILTTL PSAGIGAALA
910 920 930 940 950
LELTGKDLSF VALIGIILLM GIVKKNAIMM IDFALDAERT RGLSPEDSIM
960 970 980 990 1000
EAALLRFRPI MMTTLAALLG ALPLAIESGT GSELRNPLGI TIVGGLLLSQ
1010 1020 1030 1040 1050
LLTLYTTPVI YLAMERLRAR LTGGRKTPAT QPAPAAADDA AEQQRPRRGF

EEAAE
Length:1,055
Mass (Da):113,043
Last modified:October 5, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1A5A6A0CDEE7624
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP002083 Genomic DNA Translation: ADJ22751.1

NCBI Reference Sequences

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RefSeqi
WP_013214966.1, NC_014313.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ADJ22751; ADJ22751; Hden_0937

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hdn:Hden_0937

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002083 Genomic DNA Translation: ADJ22751.1
RefSeqiWP_013214966.1, NC_014313.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi582899.Hden_0937

Genome annotation databases

EnsemblBacteriaiADJ22751; ADJ22751; Hden_0937
KEGGihdn:Hden_0937

Phylogenomic databases

eggNOGiENOG4105BZS Bacteria
COG0841 LUCA
HOGENOMiHOG000158127
KOiK07788
OMAiFIIPCFY
OrthoDBi145346at2

Enzyme and pathway databases

BioCyciHDEN582899:G1GLW-929-MONOMER

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
InterProiView protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
PANTHERiPTHR32063 PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873 ACR_tran, 1 hit
PRINTSiPR00702 ACRIFLAVINRP
SUPFAMiSSF82714 SSF82714, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD8JUG1_HYPDA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D8JUG1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: December 11, 2019
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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