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Entry version 43 (16 Oct 2019)
Sequence version 1 (05 Oct 2010)
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Protein
Submitted name:

Transmembrane protein

Gene

Hsero_0758

Organism
Herbaspirillum seropedicae (strain SmR1)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transmembrane proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Hsero_0758Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHerbaspirillum seropedicae (strain SmR1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri757424 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerbaspirillum
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000329 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 30HelicalSequence analysisAdd BLAST19
Transmembranei36 – 57HelicalSequence analysisAdd BLAST22
Transmembranei440 – 462HelicalSequence analysisAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
757424.Hsero_0758

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini188 – 443ImcF-related_NInterPro annotationAdd BLAST256
Domaini493 – 844IcmF-relatedInterPro annotationAdd BLAST352
Domaini983 – 1184IcmF_CInterPro annotationAdd BLAST202

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1250 – 1291DisorderedSequence analysisAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili478 – 498Sequence analysisAdd BLAST21
Coiled coili916 – 936Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1273 – 1291PolarSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CU3 Bacteria
COG3523 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000255557

KEGG Orthology (KO)

More...
KOi
K11891

Identification of Orthologs from Complete Genome Data

More...
OMAi
TMYKTEY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009612 IcmF-related
IPR025743 IcmF-related_N_dom
IPR010623 IcmF_C
IPR027417 P-loop_NTPase
IPR017731 T6SS_IcmF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06761 IcmF-related, 1 hit
PF06744 IcmF_C, 1 hit
PF14331 ImcF-related_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03348 VI_IcmF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D8IZF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRLWHFLSD TRTLVIIGFA ALAAFLFIGA STLELALTWA AVILAIALLC
60 70 80 90 100
WLGYWLYRRW KVRRAAGKLG EVLEQQATQS VAASSDGAQR EEVAALRTRM
110 120 130 140 150
LEAINTIKTS KLGQKSGSAA LYELPWYMVI GNPAAGKSTA IANSGLQFPF
160 170 180 190 200
ADKGGKIVHG VGGTRNCDWF FTTDGILLDT AGRYSVYEED RNEWFSFLGL
210 220 230 240 250
LKRYRKQAPI NGIIIAVSIA ELTGNRPEFA INLAKNLRQR VQELTEKLEV
260 270 280 290 300
FAPVYVVFTK ADLITGFNEF FLDTERSERD RVWGATLAYD RKRSGQEVVS
310 320 330 340 350
FFDERFDELY AGLKEMSLAS MSVKRGENMA PGVLTFPLEF SSIKGVLRSF
360 370 380 390 400
VATLFEENPF QFKPVFRGFY FTSAVQEGAT VSASSQRIAD RFGLALEHKP
410 420 430 440 450
QREIFSQHGF FLHNLFKQVI FADKQLVAQY TSRTKIRMRY ATFFAAIAIL
460 470 480 490 500
GVLLGGWSWS YMGNRQLLAN VQADMDKAVK LQEKRLDLQS RFEALEILQD
510 520 530 540 550
RIEQLDRYRA SRPISVGMGL YQGDLLERKL REEYFSGIKE IMLKPVASNI
560 570 580 590 600
ESYLMEVNAN AARLEPMSRP PQSGGITPVA DNGAQAASAL RTYKDSSATS
610 620 630 640 650
VEDAYNALKT YLMLADKSRA ESSHLNDQIT RFWRGWLETN RGTMPREQMI
660 670 680 690 700
RSAERLISFS LEQINDPSWP TIDNKLTLVD QARENLRRVV RGMPARERVY
710 720 730 740 750
ADVKARAATR FASMTVARIV GDKDRELVMG SYAIPGTFTR DAWEKFVQEA
760 770 780 790 800
FKEAANKELQ SADWVLKTSA KDDLTLEGSP EQIQKALVTQ YKTEYAREWQ
810 820 830 840 850
KFLQGVSIVE LRNLDDATNA MNRLGDPITS PMKKVINTVY DETSWDNPSL
860 870 880 890 900
VDAGLANAKS GFMGWFKETI LRRSPAPAPT QFNADGTTAI PMGPVGREFS
910 920 930 940 950
GVARLVVSKD KNGSLLQTYL DNLSKLRTRL NTIKNQGDTG PGAKQLMQQT
960 970 980 990 1000
LEGNGSELSD SLKFVDEEML PGLNDQQKTV LRPLLVRPLV QGFNALVRPT
1010 1020 1030 1040 1050
EGEVNKIWRA QVYEPFQSNL AAKYPFSPNS KIEANSGEIG TVFGENGAIS
1060 1070 1080 1090 1100
KFVTTAMGPL VVRRGDTLSP RKWADMGINL SPAITSNFAS WISAPGGGGD
1110 1120 1130 1140 1150
ANGGANSAQT VFQIQPQPAP GALEYTIEID GQQLRYRNTQ AQWTNFIWPN
1160 1170 1180 1190 1200
PQGTPGARVT AQTYDGRTIE VASQPGRFGL ERLINSAQRK RKDNGVFELS
1210 1220 1230 1240 1250
WTNEGVTVVV NLKIISSAEV SGTANGPARG TASLRGLKLP ETIAGGAPAP
1260 1270 1280 1290
VLAPAPAGAA GTAPMQPGQP MATDAAAPQS NNQPTITGVK Q
Length:1,291
Mass (Da):142,725
Last modified:October 5, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2AF51532FB6048F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP002039 Genomic DNA Translation: ADJ62277.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ADJ62277; ADJ62277; Hsero_0758

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hse:Hsero_0758

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002039 Genomic DNA Translation: ADJ62277.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi757424.Hsero_0758

Genome annotation databases

EnsemblBacteriaiADJ62277; ADJ62277; Hsero_0758
KEGGihse:Hsero_0758

Phylogenomic databases

eggNOGiENOG4105CU3 Bacteria
COG3523 LUCA
HOGENOMiHOG000255557
KOiK11891
OMAiTMYKTEY

Family and domain databases

InterProiView protein in InterPro
IPR009612 IcmF-related
IPR025743 IcmF-related_N_dom
IPR010623 IcmF_C
IPR027417 P-loop_NTPase
IPR017731 T6SS_IcmF
PfamiView protein in Pfam
PF06761 IcmF-related, 1 hit
PF06744 IcmF_C, 1 hit
PF14331 ImcF-related_N, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03348 VI_IcmF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD8IZF7_HERSS
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D8IZF7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: October 16, 2019
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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