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Protein

Octanoyl-[GcvH]:protein N-octanoyltransferase

Gene

lplA3

Organism
Bacillus cereus var. anthracis (strain CI)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes.UniRule annotation

Miscellaneous

The reaction proceeds via a thioester-linked acyl-enzyme intermediate.UniRule annotation

Catalytic activityi

[Glycine cleavage system H]-N6-octanoyl-L-lysine + a [lipoyl-carrier protein] = glycine cleavage system H + a [lipoyl-carrier protein]-N6-octanoyl-L-lysine.UniRule annotation

Pathwayi: protein lipoylation via endogenous pathway

This protein is involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein].UniRule annotation This subpathway is part of the pathway protein lipoylation via endogenous pathway, which is itself part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein lipoylation via endogenous pathway and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149Acyl-thioester intermediateUniRule annotation1
Sitei161Lowers pKa of active site CysUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, LigaseImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Octanoyl-[GcvH]:protein N-octanoyltransferaseUniRule annotation (EC:2.3.1.204UniRule annotation)
Alternative name(s):
Octanoyl-[GcvH]:E2 amidotransferaseUniRule annotation
Gene namesi
Name:lplA3Imported
Synonyms:lipLUniRule annotation
Ordered Locus Names:BACI_c53810Imported
OrganismiBacillus cereus var. anthracis (strain CI)Imported
Taxonomic identifieri637380 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001657 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD8H4W1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 229BPL/LPL catalyticInterPro annotationAdd BLAST186

Sequence similaritiesi

Belongs to the octanoyltransferase LipL family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000078071
KOiK16869
OMAiVVRTWVH
OrthoDBiPOG091H07SF

Family and domain databases

HAMAPiMF_02119 LipL, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024897 LipL
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

D8H4W1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNSRSILSQ PEWRIVDQSS LGPTFHALQS FAMDDTLCTS IGKGESAATM
60 70 80 90 100
RSWVHHNTIV LGIQDSRLPH LEEGISFLKE NNFNVIVRNS GGLAVVLDEG
110 120 130 140 150
VLNVSLLFQE TEKGIDIDLG YDTMWHLIQE MLKDYDVTIE AKEIVGSYCP
160 170 180 190 200
GSYDLSIRDQ KFAGISQRRI RGGVAVQIYL CATGSGSERA TLVRDFYNLA
210 220 230 240 250
IQGEETRFTY PEIVPSTMAS LSELLNETIT VQDLMMRLLK TLQQFAPKLT
260 270 280
PSQLTIDEIP LYETNLQRII DRNNKALGLE K
Length:281
Mass (Da):31,478
Last modified:October 5, 2010 - v1
Checksum:i09282D85E2415247
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001746 Genomic DNA Translation: ADK07927.1
RefSeqiWP_000071932.1, NC_014335.1

Genome annotation databases

EnsemblBacteriaiADK07927; ADK07927; BACI_c53810
KEGGibal:BACI_c53810

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001746 Genomic DNA Translation: ADK07927.1
RefSeqiWP_000071932.1, NC_014335.1

3D structure databases

ProteinModelPortaliD8H4W1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADK07927; ADK07927; BACI_c53810
KEGGibal:BACI_c53810

Phylogenomic databases

HOGENOMiHOG000078071
KOiK16869
OMAiVVRTWVH
OrthoDBiPOG091H07SF

Family and domain databases

HAMAPiMF_02119 LipL, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024897 LipL
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD8H4W1_BACAI
AccessioniPrimary (citable) accession number: D8H4W1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: September 27, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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