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Entry version 64 (11 Dec 2019)
Sequence version 1 (10 Aug 2010)
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Protein
Submitted name:

Laminin alpha 5

Gene

lama5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • integrin binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Laminin alpha 5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lama5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-9823 lama5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500310531830 – 3664Sequence analysisAdd BLAST3635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi316 ↔ 325PROSITE-ProRule annotation
Disulfide bondi388 ↔ 397PROSITE-ProRule annotation
Disulfide bondi441 ↔ 450PROSITE-ProRule annotation
Disulfide bondi482 ↔ 494PROSITE-ProRule annotation
Disulfide bondi505 ↔ 514PROSITE-ProRule annotation
Disulfide bondi529 ↔ 541PROSITE-ProRule annotation
Disulfide bondi531 ↔ 548PROSITE-ProRule annotation
Disulfide bondi550 ↔ 559PROSITE-ProRule annotation
Disulfide bondi575 ↔ 587PROSITE-ProRule annotation
Disulfide bondi595 ↔ 604PROSITE-ProRule annotation
Disulfide bondi620 ↔ 632PROSITE-ProRule annotation
Disulfide bondi640 ↔ 649PROSITE-ProRule annotation
Disulfide bondi665 ↔ 677PROSITE-ProRule annotation
Disulfide bondi667 ↔ 684PROSITE-ProRule annotation
Disulfide bondi686 ↔ 695PROSITE-ProRule annotation
Disulfide bondi713 ↔ 730PROSITE-ProRule annotation
Disulfide bondi732 ↔ 741PROSITE-ProRule annotation
Disulfide bondi785 ↔ 794PROSITE-ProRule annotation
Disulfide bondi815 ↔ 827PROSITE-ProRule annotation
Disulfide bondi817 ↔ 834PROSITE-ProRule annotation
Disulfide bondi836 ↔ 845PROSITE-ProRule annotation
Disulfide bondi1421 ↔ 1433PROSITE-ProRule annotation
Disulfide bondi1423 ↔ 1440PROSITE-ProRule annotation
Disulfide bondi1442 ↔ 1451PROSITE-ProRule annotation
Disulfide bondi1483 ↔ 1492PROSITE-ProRule annotation
Disulfide bondi1534 ↔ 1543PROSITE-ProRule annotation
Disulfide bondi1559 ↔ 1571PROSITE-ProRule annotation
Disulfide bondi1561 ↔ 1578PROSITE-ProRule annotation
Disulfide bondi1580 ↔ 1589PROSITE-ProRule annotation
Disulfide bondi1862 ↔ 1871PROSITE-ProRule annotation
Disulfide bondi1920 ↔ 1929PROSITE-ProRule annotation
Disulfide bondi1975 ↔ 1984PROSITE-ProRule annotation
Disulfide bondi1987 ↔ 2001PROSITE-ProRule annotation
Disulfide bondi2023 ↔ 2032PROSITE-ProRule annotation
Disulfide bondi2051 ↔ 2063PROSITE-ProRule annotation
Disulfide bondi2053 ↔ 2070PROSITE-ProRule annotation
Disulfide bondi2072 ↔ 2081PROSITE-ProRule annotation
Disulfide bondi2115 ↔ 2124PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 291Laminin N-terminalInterPro annotationAdd BLAST254
Domaini292 – 350Laminin EGF-likeInterPro annotationAdd BLAST59
Domaini351 – 420Laminin EGF-likeInterPro annotationAdd BLAST70
Domaini421 – 465Laminin EGF-likeInterPro annotationAdd BLAST45
Domaini478 – 515EGF-likeInterPro annotationAdd BLAST38
Domaini482 – 528Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini529 – 574Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini575 – 619Laminin EGF-likeInterPro annotationAdd BLAST45
Domaini620 – 664Laminin EGF-likeInterPro annotationAdd BLAST45
Domaini665 – 710Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini704 – 742EGF-likeInterPro annotationAdd BLAST39
Domaini712 – 761Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini762 – 814Laminin EGF-likeInterPro annotationAdd BLAST53
Domaini815 – 861Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini1421 – 1466Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini1467 – 1510Laminin EGF-likeInterPro annotationAdd BLAST44
Domaini1511 – 1558Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini1559 – 1609Laminin EGF-likeInterPro annotationAdd BLAST51
Domaini1630 – 1809Laminin IV type AInterPro annotationAdd BLAST180
Domaini1843 – 1893Laminin EGF-likeInterPro annotationAdd BLAST51
Domaini1894 – 1949Laminin EGF-likeInterPro annotationAdd BLAST56
Domaini1950 – 2003Laminin EGF-likeInterPro annotationAdd BLAST54
Domaini2004 – 2050Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini2051 – 2098Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini2099 – 2145Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini2725 – 2917LAM_G_DOMAINInterPro annotationAdd BLAST193
Domaini2932 – 3100LAM_G_DOMAINInterPro annotationAdd BLAST169
Domaini3107 – 3274LAM_G_DOMAINInterPro annotationAdd BLAST168
Domaini3317 – 3481LAM_G_DOMAINInterPro annotationAdd BLAST165
Domaini3488 – 3662LAM_G_DOMAINInterPro annotationAdd BLAST175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3278 – 3311DisorderedSequence analysisAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2212 – 2246Sequence analysisAdd BLAST35
Coiled coili2314 – 2334Sequence analysisAdd BLAST21
Coiled coili2346 – 2373Sequence analysisAdd BLAST28
Coiled coili2388 – 2415Sequence analysisAdd BLAST28
Coiled coili2464 – 2484Sequence analysisAdd BLAST21
Coiled coili2541 – 2561Sequence analysisAdd BLAST21
Coiled coili2576 – 2603Sequence analysisAdd BLAST28
Coiled coili2691 – 2711Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3289 – 3311PolarSequence analysisAdd BLAST23

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotation, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IP6D Eukaryota
ENOG410YNSE LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231235

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 19 hits
PF02210 Laminin_G_2, 4 hits
PF06008 Laminin_I, 1 hit
PF06009 Laminin_II, 1 hit
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 13 hits
SM00180 EGF_Lam, 21 hits
SM00281 LamB, 1 hit
SM00282 LamG, 5 hits
SM00136 LamNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 2 hits
PS50026 EGF_3, 2 hits
PS01248 EGF_LAM_1, 7 hits
PS50027 EGF_LAM_2, 21 hits
PS50025 LAM_G_DOMAIN, 5 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D7PSA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARGPSGRAS RTPVLVFLPL LLLTGTLTAQ ELPVNGVNGF SLHPPYFNLA
60 70 80 90 100
EGTKITATAT CGVDENEQPI QDLYCKLVGG PVSGDPSQTI QGQYCDICSS
110 120 130 140 150
QDTNRAHPIS NAIDGTERWW QSPPLSRSAK HNQVNVTLDL GQLFHVAYVL
160 170 180 190 200
IKFANSPRPD LWVLERSIDF GKTYQPWQFF ASSKRDCIER FGQRTIERIY
210 220 230 240 250
HDDDVICTTE YSRIVPLENG EIVVSLVNGR PGAMNFSYSP VLREFTKATN
260 270 280 290 300
IRLRFLRTNT LLGHLMGKTL RDPTVTRRYY YSIKDISIGG RCVCNGHAEA
310 320 330 340 350
CNAQDPNDPY KLQCDCQHNT CGTSCDRCCP GFNQFPWKPA TTYSANECEP
360 370 380 390 400
CNCHRHSSEC YYDPEIDQRR SSLDMQGEYN GGGVCVECQH HTTGVNCERC
410 420 430 440 450
IPGYYRSPDH PLESPFACSK CQCESEFTEG TCEDRTGRCY CKPNYTGENC
460 470 480 490 500
DQCAEGYEHF PECYQVLING EVRPAGENII DCECNAAGTE GNSCRPDPRT
510 520 530 540 550
NTCVCKPEFT GEHCDTCSHG YFSINCQRCQ CSGQGCLDGS CDAVTGQCVC
560 570 580 590 600
RSGFQGYSCE QCAPGYFNYP LCQYCGCSVV GSIPEMCDPA GRCLCRPEFT
610 620 630 640 650
GPRCDQCQSG FHSYPNCQVC TCDPRTSLDS SCSELDQCNC RPNYSGPRCQ
660 670 680 690 700
QCAPGYYSYP SCTPCDCSVE GSRSSSCDPV SGQCVCLPNI EGQRCDSCSP
710 720 730 740 750
GSYGFPLCQL GTCNPAGSVH NDILPTVGSC VCRPYVEGVA CERCKPLYWN
760 770 780 790 800
LSPDTIYGCS TCDCNTAGTL SEVAECTQRT GQCFCKPNVC SGTCNVCKDG
810 820 830 840 850
FFNLQKDSYF GCQGCQCDIG GSVGQACDER YGRCRCRPNV EGPKCKQPRP
860 870 880 890 900
DHYFPDLHHM KFEVEDGTTM DGRPVRFGYN PLEFESFSWR GYAQMSPIQP
910 920 930 940 950
RVLVEVVVGS PDLFHVVLHY VNRGGVDVTG QVSVIEDGRH VLCGNCSEQS
960 970 980 990 1000
KQIVFAPSSE PTFVNVPQNS FVEPFVLNPG TWTVIIEAEG ILLDYLVLLP
1010 1020 1030 1040 1050
SAYYEAPILQ LQVTEPCSYS HTQDASQNCL QYMYLSLDEF PSISSNDASC
1060 1070 1080 1090 1100
RSDNHLPRPC HTEKITPRHP SMAICSGNDI SVGLRGRVPV PGEYVLVVEY
1110 1120 1130 1140 1150
ASEDQAPQNL TVSVSSAGES THQEQITLLH CKYSFLCRSV SVDDMKRVAL
1160 1170 1180 1190 1200
FTISANAEIQ LIAERSSFFL HKVFLIPRAQ FTMEYLKPRV HCISTHGHFA
1210 1220 1230 1240 1250
PDSGSCIPSR FQNPPQSLVL KEGQASSVAE PILASAPDPS LYADRPMTST
1260 1270 1280 1290 1300
PPTATDNTEH VLLDTSQNAV VYSTRVHALG RYVFILHYHQ PLHPTYNVQV
1310 1320 1330 1340 1350
FINGGRIWQG NVNASFCPHG YGCRSVVMSE NQIILDVTDH EVILTLRVPD
1360 1370 1380 1390 1400
RKTLWLDYVL VVPEGSYSSS FLSEELLDKS YDFISNCGQN SFYINPSSAS
1410 1420 1430 1440 1450
AFCLSSAVSL SSFFNNGAVP CGCHEVGAES DTCESFGGQC RCRPNVIGRD
1460 1470 1480 1490 1500
CSQCATGYYG FPNCRPCNCG SRLCEPVTGE CICPPRTLQP DCVTCEPQTF
1510 1520 1530 1540 1550
GCHPLVGCEM CNCSRPGVTS MDISCDTNNG QCRCRNNIVG RQCDRCXPGF
1560 1570 1580 1590 1600
YGYPNCRPCN CNEAGTEMNV CDSFTGRCLC KENVEGPRCD QCKLGTFHLD
1610 1620 1630 1640 1650
PTNAKGCTKC FCFGATDRCH SSDKRRSEIM DMAGWVLLRS DRQEVPVSTY
1660 1670 1680 1690 1700
LDQDLVEADL SDVPDVSQDL HWHAPQAYHG DKVSSYGGYL RYRLHTQTMR
1710 1720 1730 1740 1750
GDAFLMVETI RPDVILKGNQ MTLVYMEREY PSPEDPHEGI VHLVEESFRH
1760 1770 1780 1790 1800
AQTGNSVSRE ELMMVLVALE SLQIRALHSQ SAQSVSLRAA VLEVAENMPS
1810 1820 1830 1840 1850
GRHANNVEIC LCPGNYLGDS CQQCAPGYYR DNKGLFLGKC VPCNCNGHSD
1860 1870 1880 1890 1900
QCLDGSGICV NCRHNTAGNH CEKCLGGFHH NNTVDGHSVS CSSCPCPLQV
1910 1920 1930 1940 1950
ASNNFAIRCV EKPNNMRCLC MPGYAGSKCE RCAPGYYGNP VVIGSTCQPC
1960 1970 1980 1990 2000
NCNGNSDPNM LFSDCHPLTG ECQSCMHNTA GPHCEICAPG FYGDAITAKN
2010 2020 2030 2040 2050
CTRCNCSPCG TAHCDSHTGQ CHCKPGVVGA QCDRCEHGTF GFDSCTGCRK
2060 2070 2080 2090 2100
CDCDASAALV QACDPVNGAC ACQPGVNGPN CHQCAPGHWN YSSNGCRKCE
2110 2120 2130 2140 2150
CKGGRCDPRT GECRCTTGLT GKQCDTCLSQ HSVPVQNGAD MHCQPCDSCV
2160 2170 2180 2190 2200
MVLLEDLDRI SHFYESVANQ LTSLNASTFA WTQLNRLNAS IADIANAITN
2210 2220 2230 2240 2250
YNSTLDKSRN RASVLEGELE IIDSDIKDLE KKASVTQKKK DALEDNINST
2260 2270 2280 2290 2300
HTRAQELFGF IKGIMRDVKD IIQQVNRTAQ NETQVMDEKD LARKIAEVES
2310 2320 2330 2340 2350
MLRBMRFRGF DYQKNKAKNE LDQANNLVDR VINEIANRTW NNEAVAENIR
2360 2370 2380 2390 2400
NKLKQFNEQL MDLRDAMNEA VNNTAQTVEA NNINQKHLED LQKKVNSLHE
2410 2420 2430 2440 2450
KYKEVVSQLQ MAEDDVTQVN DLLSMLQDSK EDYEHLAAQL DGARQPLAEK
2460 2470 2480 2490 2500
VQKYAPAANK IPLVEAAEKH AEMLEQLANN LSSLISGSNQ DNFIQRALNA
2510 2520 2530 2540 2550
SRAYTNIINS VLEAETTALK ANETASMALE NIRDKDLPAQ AAALKNQSTE
2560 2570 2580 2590 2600
LLKSAEELNN SSQSLKPRVD TIKMSLLDAE KKKEKMLQDL KDIQNKLNVS
2610 2620 2630 2640 2650
RDDIVNSISA AKSAVEQANN TVANVSGVLA PIQKQLEEWQ KQYGDSNATS
2660 2670 2680 2690 2700
EDINKALNDA NTSVAALSDT LPKLIKKLDR LHNTTFQPSN ISDSIQRIRQ
2710 2720 2730 2740 2750
LIEQARNAAN KVSVSMQFNG KSGVQVRTPS NVADLAAYSS LQMYIKLPSP
2760 2770 2780 2790 2800
TIKKKRQTEA TNPQFVLYLG NRDSSKEYMA VTLNGKKLRW HFNVGGSSVD
2810 2820 2830 2840 2850
VLMDEDVKND FFNKLILERT LQYGQMSMTT DQDENNIIKR IMEAKGQKGL
2860 2870 2880 2890 2900
LNLPAEETVF YVGGFPSTFS PPGTLNLSSP LDFFKGYVEL LSINEELISL
2910 2920 2930 2940 2950
YNFEQTFDMN TTTDAPCSRK RPANTPEWVV DGVYFDGTGY VEVLFETQKG
2960 2970 2980 2990 3000
DRTFDQTIRL ISQNGILLSF QREDKYVTIA VLDGFLRVFY NVEGSLMPGP
3010 3020 3030 3040 3050
GNPTKISNAD KKTLQVILQL NNMKMLVRLD RETLYTLYSE ELNFTGRYFL
3060 3070 3080 3090 3100
GGVPEAEMPN DLKSIYLKHG SIRGCFRIIK SMGSFVQIKT MKSSGISFGC
3110 3120 3130 3140 3150
PDDLLFTREA HFTGEGYLGL KMDYVDLANS FYGGIGFRTD QQNGLMFYHQ
3160 3170 3180 3190 3200
NKDNVCKVML DNGHVLVSTD RKEVKSQKTY NDDNNHYVAV YRDQNVLSIY
3210 3220 3230 3240 3250
IDDVLESSGE TGNVTTRRNA LQEGFTYVGG TPESNGPTNL TGCISNFFIK
3260 3270 3280 3290 3300
RANEPQIVED LKTALEGRKY TFTCPDASAP LQMLNSPRPK KNAPGNSRSR
3310 3320 3330 3340 3350
MARDSCQGDT SVQEVDAHHF SGSTHSHMRF DSLPQAFSKA PHFSISVRVN
3360 3370 3380 3390 3400
SSSGLIFHVA GGKGQRMMAL SVSDGHLTLL VNGGKRKTSI RSKKRYSDGL
3410 3420 3430 3440 3450
WHTVFVKVEG DRGSLTVDGI DTQNKRVSAG GKSMFAAPLY IGGLPVDHSA
3460 3470 3480 3490 3500
AMAGFVGCVR DLKLNEVSLQ SPSVSVGVTP CYQQPLQPGA HFSSRGGFMT
3510 3520 3530 3540 3550
IDESLVLGQD LEIQLEVRLD SGSGLLLHTG AKKTHQLSVY LEQGQVTVLM
3560 3570 3580 3590 3600
NSGSGEFSXS LTPKESLCDG GWHTIAIVKK SNVIQLHVDS FSEHGVAPKQ
3610 3620 3630 3640 3650
SRSNGGKEAV YLGGLPETIT VPGLSSSVQS FQGCVRKAVL NHRPVMLSKP
3660
LSVSGSVGTQ GCPA
Length:3,664
Mass (Da):403,568
Last modified:August 10, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86037EAEA51F5DEB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
GU936670 mRNA Translation: ADI46647.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU936670 mRNA Translation: ADI46647.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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Organism-specific databases

ZFINiZDB-GENE-030131-9823 lama5

Phylogenomic databases

eggNOGiENOG410IP6D Eukaryota
ENOG410YNSE LUCA
HOGENOMiHOG000231235

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 19 hits
PF02210 Laminin_G_2, 4 hits
PF06008 Laminin_I, 1 hit
PF06009 Laminin_II, 1 hit
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 13 hits
SM00180 EGF_Lam, 21 hits
SM00281 LamB, 1 hit
SM00282 LamG, 5 hits
SM00136 LamNT, 1 hit
SUPFAMiSSF49899 SSF49899, 5 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS50026 EGF_3, 2 hits
PS01248 EGF_LAM_1, 7 hits
PS50027 EGF_LAM_2, 21 hits
PS50025 LAM_G_DOMAIN, 5 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD7PSA0_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D7PSA0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: December 11, 2019
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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