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Protein

RNA polymerase II transcription factor B subunit 2

Gene

ARALYDRAFT_493174

Organism
Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:ARALYDRAFT_493174Imported
OrganismiArabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress)Imported
Taxonomic identifieri81972 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000008694 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi59689.fgenesh2_kg.7__2607__AT4G17020.2

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

KOiK03144
OrthoDBiEOG09360AVD

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

D7MC99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQVKIIAKN FMDMVASLPA IKLDKLYNNV FICEAILRSL PPLAKKYVLQ
60 70 80 90 100
MLYINVPVPA AMMEEWVLAD GASKHRVAID RLIQLRIFSE TSDRKRGISY
110 120 130 140 150
SLNPTFQNNL QKHIISGGVL PREPMHSDNA IKLPSLQELE TYALKQWECF
160 170 180 190 200
LLQLINSGQG EKLTGISSSM MRIFQRGLLS QRDKDGPRLT ESGFQFLLMD
210 220 230 240 250
TNAQLWYIIR EYISNAEERD VEPADLISFL LELSFHVTGE AYNSNTLTEV
260 270 280 290 300
QNNTLKDLAD LGLVKLQQGR KDSWFIPTKL ATNLSVSLAD SSARKEGFVV
310 320 330 340 350
METNFRMYAY STSKLQCEIL RLFARIEYQL PNLIACAITK ESLYNAFDNG
360 370 380 390 400
ITSDQIITFL QQNSHPRCAD RVPSIPENVT DQIRLWETDL KRIEMTQAHF
410 420 430 440 450
YDEFPSKDVF EAACDFAREW GGLLWEDSKR MRLVVKSEVH NQMREFLHNQ

TK
Length:452
Mass (Da):51,923
Last modified:August 10, 2010 - v1
Checksum:i39EBFB14F37096F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL348719 Genomic DNA Translation: EFH44350.1
RefSeqiXP_002868091.1, XM_002868045.1

Genome annotation databases

EnsemblPlantsifgenesh2_kg.7__2607__AT4G17020.2; fgenesh2_kg.7__2607__AT4G17020.2; fgenesh2_kg.7__2607__AT4G17020.2
Grameneifgenesh2_kg.7__2607__AT4G17020.2; fgenesh2_kg.7__2607__AT4G17020.2; fgenesh2_kg.7__2607__AT4G17020.2
KEGGialy:ARALYDRAFT_493174

Similar proteinsi

Entry informationi

Entry nameiD7MC99_ARALL
AccessioniPrimary (citable) accession number: D7MC99
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: February 28, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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