Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 36 (10 Apr 2019)
Sequence version 1 (10 Aug 2010)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Dicer-like 3

Gene

DCL1

Organism
Ectocarpus siliculosus (Brown alga) (Conferva siliculosa)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dicer-like 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCL1Imported
ORF Names:Esi_0039_0031Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEctocarpus siliculosus (Brown alga) (Conferva siliculosa)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri2880 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaStramenopilesPX cladePhaeophyceaeEctocarpalesEctocarpaceaeEctocarpus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002630 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome LG21

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
2880.D7FZW2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 192Helicase ATP-bindingInterPro annotationAdd BLAST183
Domaini371 – 533Helicase C-terminalInterPro annotationAdd BLAST163
Domaini1140 – 1270RNase IIIInterPro annotationAdd BLAST131
Domaini1321 – 1466RNase IIIInterPro annotationAdd BLAST146

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D7FZW2

Database of Orthologous Groups

More...
OrthoDBi
1337630at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D7FZW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPRPYQAEA FDAARKANVV MVGATGVGKT LVSLMLIRDF YFEDARRRES
60 70 80 90 100
KNHKWCIFLC PTQELVFQQA KSAQIFTGVR CGPYVGKDLD YWGVKKWKEE
110 120 130 140 150
MDNKEVLVMT PNALLNLLHR GNEYLSLKDV GVLVFDECHK ARKKHPYARV
160 170 180 190 200
MAFYLELRKN RGPLPKVFGM TASPTIECVE VLQCKAYVCE DDLIEEFQAN
210 220 230 240 250
ADWELLSYEA VVGPVLFSYQ HLGLWCAMRH IRVAENLPDR SRITRTKKVV
260 270 280 290 300
LQLTQHLTES PLGLAVCGIE RAPRSSSPAV PGIDGRGASK GVCDGGLPVP
310 320 330 340 350
RRGGSAGGRR ADGGVALRPL AGTPDDPMEE DGEEREGKDL DGVEAQNKGG
360 370 380 390 400
GSAASGVGAA GWGMTPGRVI TLVKTLLRVS EQWGDEAKNF RCMVFVERRA
410 420 430 440 450
TARVLSAFLS HSLSGRFCCG FVVGRANARG DDFGRSRMAQ TINMFRAGEV
460 470 480 490 500
QILVTTDACS EGIDVPECNL VVSMDKIKTS RSLIHTRGRA RSKGGKFVIM
510 520 530 540 550
VEDGDDMERD RVSLMLMESE DIKRFQLGHE KASVRVPLRH SHPNMVHHIE
560 570 580 590 600
SSGAVVDMDM ATPLMNQALS AVGCDFHPLL ICRLELPSFM GMPTIDTAML
610 620 630 640 650
ADEHFWSKSQ ARSAVSFLAV VQMLEKGYID KRLNPTRGKA AWLRPRSGGG
660 670 680 690 700
EGSPHQGQDE AKSPEADAPS ETAATAGSPP FPGAFGDGSQ GEGDVQPGGP
710 720 730 740 750
GAPGIGPAAA GAGFAVWEGA RTRGCYEDDP GPKRRMRVYC FRTSAKEGEE
760 770 780 790 800
GEEGEEEDEE VLVEEEEHEA DMRSFHPKLK VDLGRGPGKG LGPRLFVGLA
810 820 830 840 850
SAAPLPLTAS QAAKVGIVDS FDVDLNPAQM AAIVQWHKET VGMAALYEIP
860 870 880 890 900
HQMMQTPLND PAKSPFRVSV LAVPVDYGDD GPAGDGVVKI DWPAIEAANA
910 920 930 940 950
GVHLPDKTDE TTTTLEIYLR RCLESDQGPY AGLPCETITP HDAGRMGRVK
960 970 980 990 1000
GVLAVGHGVR KPDYDAADKS QRLLLGVPAP ALKHSFAQHL VRGEKVMDPD
1010 1020 1030 1040 1050
AGVRSRVKVK RPSKKSLEDD GQVDGAMGVT EKGEDNPEER GDAPSPAADA
1060 1070 1080 1090 1100
AGTEQQGGDA EDKEEEEDND DEITVSMQES DDGGDDDAMV VEAPVERPAA
1110 1120 1130 1140 1150
SSESAAGEMA VEAAIVPRMF DLERQLLCFV LHESLFLPAL QTSLYHRNPP
1160 1170 1180 1190 1200
GADKSSNDKL LPVNERLETL GDAWLNYYAG FVVFQDKPVL MEEGMMTLLR
1210 1220 1230 1240 1250
KNVVSNARLL KCADGRGLRE FMYPPRSILG RPFDMWSPSL LPLPPPVKAS
1260 1270 1280 1290 1300
KKTIADVVEA LLGAALVAGG NRSAAYIMEW LGLAAASAAA TAAAAGEDPA
1310 1320 1330 1340 1350
APPLPEVYVA TKPSARLMGN IRLLEKRLGY TFRYPWLCMQ AITHPSWTIN
1360 1370 1380 1390 1400
DIPPGTVPAQ DYQRLEFLGD AVLGWMVTAH LYFASSAFTP AELTRIKVTS
1410 1420 1430 1440 1450
SCVCNASLWV IALRLDVHHV LRASPKILGH IHAFIENNGV SGTGTAPKHP
1460 1470 1480 1490 1500
ADVLEALIGA VFIDSSCCMN ASLLLEGAPP RMSMRTKAWA DMAFAVTMIS
1510 1520 1530 1540 1550
LVAASCARTA RPQTRGTVMV VVSPRWPWKV PRQTMRTDRE FTRLEGPSHS

ESAAAGV
Length:1,557
Mass (Da):168,809
Last modified:August 10, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0D48E001A38D54E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FN648586 Genomic DNA Translation: CBJ48587.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN648586 Genomic DNA Translation: CBJ48587.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi2880.D7FZW2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

InParanoidiD7FZW2
OrthoDBi1337630at2759

Family and domain databases

CDDicd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 2 hits
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD7FZW2_ECTSI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D7FZW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: April 10, 2019
This is version 36 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again