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Protein

Thiamine thiazole synthase

Gene

thi4

Organism
Methanococcus voltae (strain ATCC BAA-1334 / A3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39NADUniRule annotation1
Binding sitei66NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei138NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi166Iron; shared with adjacent protomerUniRule annotation1
Metal bindingi181IronUniRule annotation1
Binding sitei184NAD; via carbonyl oxygenUniRule annotation1
Binding sitei231NAD; via amide nitrogenUniRule annotation1
Binding sitei241GlycineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi58 – 59NADUniRule annotation2
Nucleotide bindingi164 – 166NAD; shared with adjacent protomerUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processThiamine biosynthesisUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation, NADUniRule annotation

Enzyme and pathway databases

BioCyciMVOL456320:G1FZ2-736-MONOMER
UniPathwayi
UPA00060

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine thiazole synthaseUniRule annotation (EC:4.-.-.-UniRule annotation)
Gene namesi
Name:thi4UniRule annotation
Ordered Locus Names:Mvol_0738Imported
OrganismiMethanococcus voltae (strain ATCC BAA-1334 / A3)Imported
Taxonomic identifieri456320 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000007722 Componenti: Chromosome

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi456320.Mvol_0738

Structurei

3D structure databases

ProteinModelPortaliD7DTD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the THI4 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00574 Archaea
COG1635 LUCA
HOGENOMiHOG000106048
KOiK22699
OMAiMWGGGMM
OrthoDBiPOG093Z09PU

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002922 Thi4_fam
IPR022828 Thi4_prok
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00292 TIGR00292, 1 hit

Sequencei

Sequence statusi: Complete.

D7DTD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKLKAEEKI VTKSILKSTF EMWMDIVDVD VVIVGAGPSG LTAGKYLAKA
60 70 80 90 100
GLKVVILERH LSFGGGTWGG GMGFPNIVVE KPADEILKEA GINLKPVNIG
110 120 130 140 150
DNPEIEAELF TADSVEVPAK LGVAAIDAGA KILTGIVVED LILKENKVSG
160 170 180 190 200
VVIQSYSIEK AGLHVDPITI SAKCVIDATG HDASVVHTLA RKNKDLNIVV
210 220 230 240 250
PGEKSMWADV GENTLVENTK EIFPNFYTCG MASNAYNAGY RMGAIFGGMY
260
LSGKKVAELI IDKLRE
Length:266
Mass (Da):28,372
Last modified:August 10, 2010 - v1
Checksum:iCAAEE6969DF27FCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002057 Genomic DNA Translation: ADI36397.1
RefSeqiWP_013180125.1, NC_014222.1

Genome annotation databases

EnsemblBacteriaiADI36397; ADI36397; Mvol_0738
GeneIDi9275960
KEGGimvo:Mvol_0738

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002057 Genomic DNA Translation: ADI36397.1
RefSeqiWP_013180125.1, NC_014222.1

3D structure databases

ProteinModelPortaliD7DTD7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi456320.Mvol_0738

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADI36397; ADI36397; Mvol_0738
GeneIDi9275960
KEGGimvo:Mvol_0738

Phylogenomic databases

eggNOGiarCOG00574 Archaea
COG1635 LUCA
HOGENOMiHOG000106048
KOiK22699
OMAiMWGGGMM
OrthoDBiPOG093Z09PU

Enzyme and pathway databases

UniPathwayi
UPA00060

BioCyciMVOL456320:G1FZ2-736-MONOMER

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002922 Thi4_fam
IPR022828 Thi4_prok
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00292 TIGR00292, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD7DTD7_METV3
AccessioniPrimary (citable) accession number: D7DTD7
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: October 10, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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