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Entry version 46 (26 Feb 2020)
Sequence version 1 (10 Aug 2010)
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Protein

Probable lipid II flippase MurJ

Gene

murJ

Organism
Desulfurivibrio alkaliphilus (strain DSM 19089 / UNIQEM U267 / AHT2)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation, TransportUniRule annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
DALK589865:G1GKN-1102-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00219

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable lipid II flippase MurJUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:murJUniRule annotation
Ordered Locus Names:DaAHT2_1079Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDesulfurivibrio alkaliphilus (strain DSM 19089 / UNIQEM U267 / AHT2)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri589865 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfurivibrio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001508 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 29HelicalUniRule annotationAdd BLAST18
Transmembranei36 – 56HelicalUniRule annotationAdd BLAST21
Transmembranei62 – 79HelicalUniRule annotationAdd BLAST18
Transmembranei91 – 112HelicalUniRule annotationAdd BLAST22
Transmembranei138 – 159HelicalUniRule annotationAdd BLAST22
Transmembranei166 – 190HelicalUniRule annotationAdd BLAST25
Transmembranei196 – 220HelicalUniRule annotationAdd BLAST25
Transmembranei241 – 264HelicalUniRule annotationAdd BLAST24
Transmembranei284 – 303HelicalUniRule annotationAdd BLAST20
Transmembranei323 – 349HelicalUniRule annotationAdd BLAST27
Transmembranei396 – 414HelicalUniRule annotationAdd BLAST19
Transmembranei420 – 441HelicalUniRule annotationAdd BLAST22
Transmembranei453 – 472HelicalUniRule annotationAdd BLAST20
Transmembranei492 – 513HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
589865.DaAHT2_1079

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MurJ/MviN family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG4105CJR Bacteria
COG0728 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006797_5_2_7

KEGG Orthology (KO)

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KOi
K03980

Identification of Orthologs from Complete Genome Data

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OMAi
IFFVAFK

Database of Orthologous Groups

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OrthoDBi
749401at2

Family and domain databases

Conserved Domains Database

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CDDi
cd13123 MATE_MurJ_like, 1 hit

HAMAP database of protein families

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HAMAPi
MF_02078 MurJ_MviN, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004268 MurJ

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03023 MurJ, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002869 MviN, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01806 VIRFACTRMVIN

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01695 murJ_mviN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D6Z2K2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKKSDQTGT IARSAAVVSF AVLCSRILGL VREQAFAILF GAGYAFDAFV
60 70 80 90 100
VAFRIPNMLR DLFGEGALSA AFVAVFAAYN EKGEKETWRL ASNVLVFFGL
110 120 130 140 150
FLSVLTLVGI FASEHIVRLL VQDEYIQVPG KVELTARLTA IMFPFLTLVS
160 170 180 190 200
LAAVVMGVLN TKGRFFVPAM AGSFFNLGAL IGGVSLSLLM PRFDQPAIVG
210 220 230 240 250
MAIGVLIGGV LQLGCQLPTL RRTGFRFVPH LDLRDPGLRR ILVLMMPAVI
260 270 280 290 300
GLAPLQFNIV INTYFASSLA EGTLSWLNYA FRLFWLPVGL FGVALSVATM
310 320 330 340 350
PVVSRFAAQK DMPNLKNTYV SSLTMAFCLS VPASVGLIIL AQPIVRVIFQ
360 370 380 390 400
HGRFDVAATV GTAEVLACYA VGLFAYAAVK IMVPIFYALD RPRYPVIGSF
410 420 430 440 450
LTMLVNLLII LAVLEHLEHR ALALSISGAM TVNFIFLSVM LYRLMGGYPL
460 470 480 490 500
AGLARGLGKI VLASLLMAGW LYGLQRLFFP GGISEERLLL DIAAVAVCIG
510 520
SSALLYGLAL QLLKLEEMNL LVRRLLRRG
Length:529
Mass (Da):57,346
Last modified:August 10, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD1E626689F9EB1B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP001940 Genomic DNA Translation: ADH85777.1

NCBI Reference Sequences

More...
RefSeqi
WP_013163306.1, NC_014216.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ADH85777; ADH85777; DaAHT2_1079

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dak:DaAHT2_1079

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001940 Genomic DNA Translation: ADH85777.1
RefSeqiWP_013163306.1, NC_014216.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi589865.DaAHT2_1079

Genome annotation databases

EnsemblBacteriaiADH85777; ADH85777; DaAHT2_1079
KEGGidak:DaAHT2_1079

Phylogenomic databases

eggNOGiENOG4105CJR Bacteria
COG0728 LUCA
HOGENOMiCLU_006797_5_2_7
KOiK03980
OMAiIFFVAFK
OrthoDBi749401at2

Enzyme and pathway databases

UniPathwayiUPA00219
BioCyciDALK589865:G1GKN-1102-MONOMER

Family and domain databases

CDDicd13123 MATE_MurJ_like, 1 hit
HAMAPiMF_02078 MurJ_MviN, 1 hit
InterProiView protein in InterPro
IPR004268 MurJ
PfamiView protein in Pfam
PF03023 MurJ, 1 hit
PIRSFiPIRSF002869 MviN, 1 hit
PRINTSiPR01806 VIRFACTRMVIN
TIGRFAMsiTIGR01695 murJ_mviN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD6Z2K2_DESAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D6Z2K2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: February 26, 2020
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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