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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Thermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei58NucleophileUniRule annotation1
Binding sitei137SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processtRNA processingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTBIS469371:G1GL8-598-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotationImported
Ordered Locus Names:Tbis_0595Imported
OrganismiThermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51)Imported
Taxonomic identifieri469371 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteria incertae sedisThermobispora
Proteomesi
  • UP000006640 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi469371.Tbis_0595

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini171 – 273PseudoU_synth_1InterPro annotationAdd BLAST103

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DI7 Bacteria
COG0101 LUCA
HOGENOMiHOG000248674
KOiK06173
OMAiFLYGMVR
OrthoDBiPOG091H010Q

Family and domain databases

Gene3Di3.30.70.660, 1 hit
HAMAPiMF_00171 TruA, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 1 hit
PIRSFiPIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00071 hisT_truA, 1 hit

Sequencei

Sequence statusi: Complete.

D6Y547-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRDPVRFRL DLGYDGTDFQ GWARQPGLRT VQGELEAALA TLLRLEAPPR
60 70 80 90 100
LTVAGRTDAG VHARGQVVHV DLPLAALAIL EPRGRETATP PAERLPELCS
110 120 130 140 150
ALVRRLAAVL PPDVRVFAVS VPPDGFDARF SALCRRYCYR VCDAPGGVDP
160 170 180 190 200
LRRREVLWYP KPLDVELMNA ASVRLLGEHD FAAFCKKREG ATTIRELRRF
210 220 230 240 250
EWARRDDGII EATVVADAFC HSMVRSLVGA VLAVGEGKRP VEWPAEVLAR
260 270 280 290
AVRDSAVRVA PAHGLTLEEV RYPETAEELA RRAAQARRVR TLTS
Length:294
Mass (Da):32,509
Last modified:August 10, 2010 - v1
Checksum:i1A11C58B091D36DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001874 Genomic DNA Translation: ADG87322.1
RefSeqiWP_013130855.1, NC_014165.1

Genome annotation databases

EnsemblBacteriaiADG87322; ADG87322; Tbis_0595
KEGGitbi:Tbis_0595

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001874 Genomic DNA Translation: ADG87322.1
RefSeqiWP_013130855.1, NC_014165.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi469371.Tbis_0595

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG87322; ADG87322; Tbis_0595
KEGGitbi:Tbis_0595

Phylogenomic databases

eggNOGiENOG4105DI7 Bacteria
COG0101 LUCA
HOGENOMiHOG000248674
KOiK06173
OMAiFLYGMVR
OrthoDBiPOG091H010Q

Enzyme and pathway databases

BioCyciTBIS469371:G1GL8-598-MONOMER

Family and domain databases

Gene3Di3.30.70.660, 1 hit
HAMAPiMF_00171 TruA, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 1 hit
PIRSFiPIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00071 hisT_truA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD6Y547_THEBD
AccessioniPrimary (citable) accession number: D6Y547
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: November 7, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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