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Entry version 63 (17 Jun 2020)
Sequence version 1 (10 Aug 2010)
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Protein
Submitted name:

Uncharacterized protein

Gene

TcasGA2_TC009818

Organism
Tribolium castaneum (Red flour beetle)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TcasGA2_TC009818Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTribolium castaneum (Red flour beetle)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7070 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Linkage group 7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7070.TC009818-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 94PDZInterPro annotationAdd BLAST78
Domaini667 – 783RGSInterPro annotationAdd BLAST117
Domaini900 – 970RBDInterPro annotationAdd BLAST71
Domaini971 – 1040RBDInterPro annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni115 – 146DisorderedSequence analysisAdd BLAST32
Regioni351 – 380DisorderedSequence analysisAdd BLAST30
Regioni493 – 525DisorderedSequence analysisAdd BLAST33
Regioni794 – 841DisorderedSequence analysisAdd BLAST48
Regioni1117 – 1137DisorderedSequence analysisAdd BLAST21
Regioni1247 – 1301DisorderedSequence analysisAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi125 – 143PolyampholyteSequence analysisAdd BLAST19
Compositional biasi500 – 525PolarSequence analysisAdd BLAST26
Compositional biasi1247 – 1264PolarSequence analysisAdd BLAST18

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3528 Eukaryota
KOG3589 Eukaryota
ENOG410YMJD LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002190_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D6WPU0

KEGG Orthology (KO)

More...
KOi
K16449

Identification of Orthologs from Complete Genome Data

More...
OMAi
HWNGFCH

Database of Orthologous Groups

More...
OrthoDBi
275783at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D6WPU0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.196.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 1 hit
PF02196 RBD, 1 hit
PF00615 RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01301 RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D6WPU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPSRRRKKR PNYGIRTVEV LRGSNGFGFT ISGQQPCILS CIVANSPADH
60 70 80 90 100
AGLRAGDFLI SVNGISVSKI THDAVVNLIG NCVGPIRMTI AENYYSDSSE
110 120 130 140 150
EELDVSRMMG ARKPKYMHKP RPHRCYKQSP SENTKKHNEN IKYNDENSGN
160 170 180 190 200
LLNISNQMSM EDEAGPVEYK ALVGYLGTIE MPKQLLPNSR LQTVCSCIKK
210 220 230 240 250
LRQEKRAPTA VLMTIFPTCL TLKNSSNHIL AIYPTNRVVY IGSTADRESR
260 270 280 290 300
YFGLVTSAVS DMRSTENLKH FQWSEDKKFN NTEPEIEISN SCHVFMIDPK
310 320 330 340 350
IVDHSVHAKK ADTFKFSCTT DVITGGCLEF PRNALYIVNL VQTMYKLQNN
360 370 380 390 400
ESPKNDEASL GPLVANSPQP SASSNSDSGI GFRDDCGNIS DRILVVEFPT
410 420 430 440 450
HRPFPIVNAT NNRPSGIDAS SIPLESLDLP LNNEINNKNH DIKSKQLNNL
460 470 480 490 500
NNIRACGSVN IKNVLGKNDN HFLTKQNNDG EVYNRLTCRA MPDRPMRVTR
510 520 530 540 550
GLSPTSSDDN TKVPDSKSSE TLSVSEDVDF QSSVDNISTH SSKSDLKGVF
560 570 580 590 600
KAPSMFFFEN KKLKRQSKMV NSCDNLDKFE ENIMNYKLSP KVYGLSKPNH
610 620 630 640 650
SCEELNNFDT VEKYGYGSLQ ELCRWDGQGK MRNIAQSEPD VRMQRNGMEC
660 670 680 690 700
EKNGPKESEG PAGWASSFEK LLDDPLGLHT FAEFLKKEFS AENIYFWTAC
710 720 730 740 750
ERYRRLPAGP ARVAEAQRIY QQHLCVGAPE GVNVDSHGRH CTEQALQEAS
760 770 780 790 800
EALFDQAQKQ IFNLMKFDSY PRFLKSSLYK QSLAGELERP QIDSGLLLQP
810 820 830 840 850
PTPTKLKKSL SNAEDRRRKS LLPWHRKNRS KSKDRGESEY CQKRGDIVTS
860 870 880 890 900
CESVNGKLGG GSDTHSSKSS LTSLDLAITS TQDLSKGSQD ETSSTVARGP
910 920 930 940 950
LCRVVLSNGS TTVVQIKTTE SIQQLVTRLL DKRGIVYSAF EVYTNKHQKA
960 970 980 990 1000
LDVTDPSTKL AGCEVTIEQR VTFKLDLPNK KVISVKSKHT KIIADVLRPI
1010 1020 1030 1040 1050
LQKYNYNLDQ AKVTIGDTEA VDIHLPVTSI DEKRLRITYC EKTVPATPVI
1060 1070 1080 1090 1100
KVNNVKAKLD EITNQVFEDI LQEKADSAFL KAKSDKGSVK SEDWGSEHSS
1110 1120 1130 1140 1150
GIFGRFLRRD SGLHDRKKKS LMKLKPPGNS SDDVTGEQVK KPLIAKWKTG
1160 1170 1180 1190 1200
VNKLQVACSE SDELVEGLTR AQRSRLEDQR GTEINFELPD FLKDKNSRFF
1210 1220 1230 1240 1250
VENGDLRRNN YENRNIMPKD FNNLTNNNNN NSFTNHNQKL NNLRIYSPNK
1260 1270 1280 1290 1300
FSSDESSPSK SLENTVIENK KDSSKCEPPP LPPKPKIVPI KPPNWGQNGY
1310 1320
YKKELGASDK KMYLEQPSSS FV
Length:1,322
Mass (Da):148,309
Last modified:August 10, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16B542B3AB488D0A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KQ971354 Genomic DNA Translation: EFA06873.1

NCBI Reference Sequences

More...
RefSeqi
XP_008195623.1, XM_008197401.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
TC009818_001; TC009818_001; TC009818

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
660124

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tca:660124

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KQ971354 Genomic DNA Translation: EFA06873.1
RefSeqiXP_008195623.1, XM_008197401.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7070.TC009818-PA

Genome annotation databases

EnsemblMetazoaiTC009818_001; TC009818_001; TC009818
GeneIDi660124
KEGGitca:660124

Phylogenomic databases

eggNOGiKOG3528 Eukaryota
KOG3589 Eukaryota
ENOG410YMJD LUCA
HOGENOMiCLU_002190_0_0_1
InParanoidiD6WPU0
KOiK16449
OMAiHWNGFCH
OrthoDBi275783at2759
PhylomeDBiD6WPU0

Family and domain databases

Gene3Di1.10.196.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF02196 RBD, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD6WPU0_TRICA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D6WPU0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 17, 2020
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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