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Protein

Proteasome subunit alpha type

Gene

TcasGA2_TC000258

Organism
Tribolium castaneum (Red flour beetle)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteasePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha typeUniRule annotation (EC:3.4.25.1UniRule annotation)
Gene namesi
ORF Names:TcasGA2_TC000258Imported
OrganismiTribolium castaneum (Red flour beetle)Imported
Taxonomic identifieri7070 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium
Proteomesi
  • UP000007266 Componenti: Linkage group 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmPROSITE-ProRule annotation, NucleusUniRule annotationSAAS annotation, ProteasomePROSITE-ProRule annotationImported

Interactioni

Subunit structurei

The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi7070.TC000258-PA

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 28PROTEASOME_ALPHA_1InterPro annotationAdd BLAST23

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0863 Eukaryota
COG0638 LUCA
InParanoidiD6WBQ6
KOiK02725
OMAiFMKQQCL
PhylomeDBiD6WBQ6

Family and domain databases

CDDicd03749 proteasome_alpha_type_1, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR035144 Proteasome_alpha1
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PANTHERiPTHR11599:SF12 PTHR11599:SF12, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

D6WBQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRNQYDSDV TVWSPQGRLH QVEYAMEAVN LGSATVGLKS KTHAVLIALK
60 70 80 90 100
RASSELSAYQ KKIINIDDHI GITISGLTAD ARILSRYMRT ECLNYKYSHD
110 120 130 140 150
THLPLNRLIS QLGNKMQLCT QRYDRRPYGV GLLVAGYDDQ GAHIYQTCPS
160 170 180 190 200
ANYYDCKAMS IGARSQSART YLEKHLEELS SCSLEELIKH GLRALRDTLP
210 220 230 240 250
PEVDLTIKNV SIGYVGKGQS FKILVDDETG PYLAMIQGEE RRGGGAQEPP
260 270
AGPLRDEAGD QDQGPRDPVP AVAMDTE
Length:277
Mass (Da):30,705
Last modified:August 10, 2010 - v1
Checksum:iA4A8B1EFF371561E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KQ971313 Genomic DNA Translation: EEZ97876.1
RefSeqiXP_966973.1, XM_961880.4

Genome annotation databases

EnsemblMetazoaiTC000258_001; TC000258_001; TC000258
GeneIDi655339
KEGGitca:655339

Similar proteinsi

Entry informationi

Entry nameiD6WBQ6_TRICA
AccessioniPrimary (citable) accession number: D6WBQ6
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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