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UniProtKB - D6RJA7 (D6RJA7_HUMAN)
Protein
Submitted name:
Myocyte-specific enhancer factor 2C
Gene
MEF2C
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProt
- protein dimerization activity Source: InterPro
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: InterPro
GO - Biological processi
- animal organ development Source: UniProt
- nervous system development Source: UniProtKB-KW
- positive regulation of transcription by RNA polymerase II Source: InterPro
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Biological process | NeurogenesisARBA annotation, Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Myocyte-specific enhancer factor 2CImported |
Gene namesi | Name:MEF2CImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6996, MEF2C |
VEuPathDBi | HostDB:ENSG00000081189 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000081189, Expressed in middle temporal gyrus and 242 other tissues |
ExpressionAtlasi | D6RJA7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 61 | MADS-boxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 91 – 116 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 175 – 194 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 93 – 116 | Basic and acidic residuesSequence analysisAdd BLAST | 24 |
Phylogenomic databases
GeneTreei | ENSGT00940000157492 |
HOGENOMi | CLU_022902_3_0_1 |
OMAi | RITEGWA |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR022102, HJURP_C IPR033896, MADS_MEF2-like IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF12347, HJURP_C, 1 hit PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 20 potential isoforms that are computationally mapped.Show allAlign All
D6RJA7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS
60 70 80 90 100
TNKLFQYAST DMDKVLLKYT EYNEPHESRT NSDIVETLRK KGLNGCDSPD
110 120 130 140 150
PDADDSVGHS PESEDKYRKI NEDIDLMISR QRLCAVPPPN FEMPVSIPVS
160 170 180 190
SHNSLVYSNP VSSLGNPNLL PLAHPSLQRN SMSPGVTHRP PSAG
Computationally mapped potential isoform sequencesi
There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ06413 | MEF2C_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 473 | Annotation score: | ||
A0A0D9SGI5 | A0A0D9SGI5_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 471 | Annotation score: | ||
D6RJG6 | D6RJG6_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 399 | Annotation score: | ||
A0A0R4J2G5 | A0A0R4J2G5_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 433 | Annotation score: | ||
A0A0D9SFD0 | A0A0D9SFD0_HUMAN | MADS box transcription enhancer fac... | MEF2C hCG_36839 | 431 | Annotation score: | ||
A0A1B0GV32 | A0A1B0GV32_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 462 | Annotation score: | ||
D8L7E9 | D8L7E9_HUMAN | Myocyte enhancer factor 2c | MEF2C | 393 | Annotation score: | ||
D6RCM6 | D6RCM6_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 129 | Annotation score: | ||
D6RG21 | D6RG21_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 126 | Annotation score: | ||
D6R942 | D6R942_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 227 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 194 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008525 Genomic DNA No translation available. AC008835 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000502831; ENSP00000427286; ENSG00000081189 |
UCSCi | uc063fgk.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008525 Genomic DNA No translation available. AC008835 Genomic DNA No translation available. |
3D structure databases
SMRi | D6RJA7 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | D6RJA7 |
ProteomicsDBi | 15089 |
Protocols and materials databases
Antibodypediai | 755, 1307 antibodies from 36 providers |
Genome annotation databases
Ensembli | ENST00000502831; ENSP00000427286; ENSG00000081189 |
UCSCi | uc063fgk.1, human |
Organism-specific databases
HGNCi | HGNC:6996, MEF2C |
OpenTargetsi | ENSG00000081189 |
VEuPathDBi | HostDB:ENSG00000081189 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157492 |
HOGENOMi | CLU_022902_3_0_1 |
OMAi | RITEGWA |
Miscellaneous databases
ChiTaRSi | MEF2C, human |
Gene expression databases
Bgeei | ENSG00000081189, Expressed in middle temporal gyrus and 242 other tissues |
ExpressionAtlasi | D6RJA7, baseline and differential |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR022102, HJURP_C IPR033896, MADS_MEF2-like IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF12347, HJURP_C, 1 hit PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D6RJA7_HUMAN | |
Accessioni | D6RJA7Primary (citable) accession number: D6RJA7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 13, 2010 |
Last sequence update: | May 27, 2015 | |
Last modified: | January 19, 2022 | |
This is version 77 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |