UniProtKB - D6RJ84 (D6RJ84_MOUSE)
Protein
Uridine-cytidine kinase
Gene
Uckl1
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
: CTP biosynthesis via salvage pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.UniRule annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- Uridine/cytidine kinase (Uck1), Uridine/cytidine kinase (Uck2), Uridine-cytidine kinase (Uck1), Uridine-cytidine kinase (Uck2), Uridine/cytidine kinase (Uck2), Uridine-cytidine kinase (Uck2), Uridine-cytidine kinase 1 (Uck1), Uridine/cytidine kinase (Uck2), Uridine-cytidine kinase 2 (Uck2), Uridine-cytidine kinase 2 (Uck2), Uridine-cytidine kinase (Uckl1)
- no protein annotated in this organism
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.
Pathwayi: UMP biosynthesis via salvage pathway
This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.UniRule annotationARBA annotationProteins known to be involved in this subpathway in this organism are:
- Uridine-cytidine kinase-like 1 (Uckl1), Uridine-cytidine kinase (Uck1), Uridine/cytidine kinase (Uckl1), Uridine-cytidine kinase (Uck2), Uridine-cytidine kinase 1 (Uck1), Uridine/cytidine kinase (Uck2), Uridine/cytidine kinase (Uckl1), Uridine-cytidine kinase (Uckl1), Uridine/cytidine kinase (Uck1), Uridine/cytidine kinase (Uck2), Uridine/cytidine kinase (Uck2), Uridine-cytidine kinase (Uck2), Uridine-cytidine kinase 2 (Uck2)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- uridine kinase activity Source: UniProtKB-EC
GO - Biological processi
- CTP salvage Source: UniProtKB-UniPathway
- UMP salvage Source: UniProtKB-UniPathway
Keywordsi
Molecular function | KinaseUniRule annotationARBA annotation, Transferase |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00574;UER00637 UPA00579;UER00640 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Uckl1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915806, Uckl1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000089917, Expressed in retinal neural layer and 278 other tissues |
ExpressionAtlasi | D6RJ84, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 101 – 287 | PRKInterPro annotationAdd BLAST | 187 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 74 | DisorderedSequence analysisAdd BLAST | 74 | |
Regioni | 303 – 339 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 56 – 71 | PolarSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT01010000222379 |
Family and domain databases
CDDi | cd02023, UMPK, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR006083, PRK/URK IPR029933, UCKL1 IPR000764, Uridine_kinase-like |
PANTHERi | PTHR10285:SF68, PTHR10285:SF68, 1 hit |
Pfami | View protein in Pfam PF00485, PRK, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00235, udk, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
D6RJ84-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPPASMSA APSPLQSAVA PDVPGRQAEQ NETACEDRSN AGTLDRLLPP
60 70 80 90 100
VGTGRSPRKR TTSQCKSEPP LLRTSKRTIY TAGRPPWYNE HGTQSKEAFA
110 120 130 140 150
IGLGGGSASG KTTVARMIIE ALDVPWVVLL SMDSFYKVLT QQQQEQAACN
160 170 180 190 200
NFNFDHPDAF DFDLIISTLK KLKQGRSVQV PIYDFTTHSR KKDWKTLYGA
210 220 230 240 250
NVIIFEGIMA FADKTLLELL DMKIFVDTDS DIRLVRRLRR DISERGRDIE
260 270 280 290 300
GVIKQYNKFV KPAFDQYIQP TMRLADIVVP RGSGNTVAID LIVQHVHSQL
310 320 330
EEGRVGLRSP VPSPPPDTEC PQEYTAGPRH AHHHQGQGD
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ91YL3 | UCKL1_MOUSE | Uridine-cytidine kinase-like 1 | Uckl1 Urkl1 | 548 | Annotation score: | ||
F6V4H6 | F6V4H6_MOUSE | Uridine/cytidine kinase | Uckl1 | 253 | Annotation score: | ||
B7ZCR1 | B7ZCR1_MOUSE | Uridine/cytidine kinase | Uckl1 | 235 | Annotation score: | ||
F7CAK3 | F7CAK3_MOUSE | Uridine-cytidine kinase-like 1 | Uckl1 | 198 | Annotation score: | ||
F6W7K4 | F6W7K4_MOUSE | Uridine-cytidine kinase-like 1 | Uckl1 | 55 | Annotation score: | ||
B7ZCR0 | B7ZCR0_MOUSE | Uridine-cytidine kinase-like 1 | Uckl1 | 16 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844529 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000129469; ENSMUSP00000121607; ENSMUSG00000089917 |
UCSCi | uc008omt.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844529 Genomic DNA No translation available. |
3D structure databases
SMRi | D6RJ84 |
ModBasei | Search... |
Proteomic databases
MaxQBi | D6RJ84 |
PeptideAtlasi | D6RJ84 |
PRIDEi | D6RJ84 |
Protocols and materials databases
Antibodypediai | 1482, 130 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000129469; ENSMUSP00000121607; ENSMUSG00000089917 |
UCSCi | uc008omt.1, mouse |
Organism-specific databases
MGIi | MGI:1915806, Uckl1 |
Phylogenomic databases
GeneTreei | ENSGT01010000222379 |
Enzyme and pathway databases
UniPathwayi | UPA00574;UER00637 UPA00579;UER00640 |
Miscellaneous databases
ChiTaRSi | Uckl1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000089917, Expressed in retinal neural layer and 278 other tissues |
ExpressionAtlasi | D6RJ84, baseline and differential |
Family and domain databases
CDDi | cd02023, UMPK, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR006083, PRK/URK IPR029933, UCKL1 IPR000764, Uridine_kinase-like |
PANTHERi | PTHR10285:SF68, PTHR10285:SF68, 1 hit |
Pfami | View protein in Pfam PF00485, PRK, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00235, udk, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D6RJ84_MOUSE | |
Accessioni | D6RJ84Primary (citable) accession number: D6RJ84 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | December 2, 2020 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |