Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Rho guanine nucleotide exchange factor (GEF) 11

Gene

Arhgef11

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-416572 Sema4D induced cell migration and growth-cone collapse

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor (GEF) 11Imported
Gene namesi
Name:Arhgef11Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2441869 Arhgef11

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiD6RGQ8
PeptideAtlasiD6RGQ8
PRIDEiD6RGQ8

Expressioni

Gene expression databases

BgeeiENSMUSG00000041977 Expressed in 236 organ(s), highest expression level in ear
ExpressionAtlasiD6RGQ8 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliD6RGQ8
SMRiD6RGQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 111PDZInterPro annotationAdd BLAST65
Domaini353 – 443RGSInterPro annotationAdd BLAST91

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili205 – 225Sequence analysisAdd BLAST21
Coiled coili442 – 462Sequence analysisAdd BLAST21
Coiled coili487 – 507Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3520 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00760000119193
HOGENOMiHOG000203503

Family and domain databases

CDDicd08753 RGS_PDZRhoGEF, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR032919 PDZ-RhoGEF
IPR036034 PDZ_sf
IPR037889 PDZRhoGEF_RGS
IPR016137 RGS
IPR015212 RGS-like_dom
IPR036305 RGS_sf
PANTHERiPTHR12673:SF111 PTHR12673:SF111, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF09128 RGS-like, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50132 RGS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

D6RGQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIRLPHSID RLSSLSSLGD STPERTSPSH HRQPSDTSET TGLVQRCVII
60 70 80 90 100
QKDQHGFGFT VSGDRIVLVQ SVRPGGAAMR AGVKEGDRII KVNGTMVTNS
110 120 130 140 150
SHLEVVKLIK SGAYVALTLL GSSPSSIGVS GLQQNPSLSG GPRVNPMIPP
160 170 180 190 200
PPPPPPLPPP QHITGPKPLQ DPEVQKHATQ ILRNMLRQEE KELQRICEVY
210 220 230 240 250
SRNPASLLEE QIEGARRRVT QLQLKIQQET GGLVDVLPLC GETSQRTCEG
260 270 280 290 300
RLSVDSQEAD SGLDSGTERF PSISESLVNR NSVLSDPGLD SPQTSPVILA
310 320 330 340 350
RVGQHHRRQG SDAAVHPLNH QGIDQSPKPL IIGPEEDYDP GYFNNESDII
360 370 380 390 400
FQDLEKLKSH PAYLVVFLRY IFSQADPGPL LFYLCSEVYQ QTNPKDSRNL
410 420 430 440 450
GKDIWNIFLE KNAPLRVKIP EMLQAEIDLR LRNSEDPRSA LYEAQEAVMP
460 470 480 490 500
EIQEQINDYR SKRTLGLGSL YGENDLLDLD GDPLRERQMA EKQLAALGDI
510 520 530 540 550
LSKYEEDRSA PMDFAVNTYM SHTGIRLRES RPSSTAEKTQ SAPDKDKWLP
560 570 580 590 600
FFPKTKKSSN SKKEKDALED KKRNPILRYI GKPKSSSQSI HAQRFALAAL

KASRAGRR
Length:608
Mass (Da):67,456
Last modified:July 13, 2010 - v1
Checksum:i92F7FB8DE059610E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q68FM7Q68FM7_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef11
1,552Annotation score:
E9Q0A3E9Q0A3_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef11
1,475Annotation score:
A0A1D5RLI4A0A1D5RLI4_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef11
205Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139241 Genomic DNA No translation available.
AC161454 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000152006; ENSMUSP00000122166; ENSMUSG00000041977
UCSCiuc008psk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139241 Genomic DNA No translation available.
AC161454 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliD6RGQ8
SMRiD6RGQ8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiD6RGQ8
PeptideAtlasiD6RGQ8
PRIDEiD6RGQ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000152006; ENSMUSP00000122166; ENSMUSG00000041977
UCSCiuc008psk.1 mouse

Organism-specific databases

MGIiMGI:2441869 Arhgef11

Phylogenomic databases

eggNOGiKOG3520 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00760000119193
HOGENOMiHOG000203503

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-416572 Sema4D induced cell migration and growth-cone collapse

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041977 Expressed in 236 organ(s), highest expression level in ear
ExpressionAtlasiD6RGQ8 baseline and differential

Family and domain databases

CDDicd08753 RGS_PDZRhoGEF, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR032919 PDZ-RhoGEF
IPR036034 PDZ_sf
IPR037889 PDZRhoGEF_RGS
IPR016137 RGS
IPR015212 RGS-like_dom
IPR036305 RGS_sf
PANTHERiPTHR12673:SF111 PTHR12673:SF111, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF09128 RGS-like, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD6RGQ8_MOUSE
AccessioniPrimary (citable) accession number: D6RGQ8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again