ADRA2C

Functionⁱ

GO - Molecular functionⁱ

alpha2-adrenergic receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

platelet activation Source: InterPro
regulation of smooth muscle contraction Source: InterPro
regulation of vasoconstriction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptorUniRule annotation, Receptor, Transducer

Molecular function

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Alpha-2C adrenergic receptorImported
Gene namesⁱ	Name:ADRA2CImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000184160.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:283 ADRA2C

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	50 – 76	HelicalSequence analysisAdd BLAST	27
Transmembraneⁱ	88 – 109	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	115 – 147	HelicalSequence analysisAdd BLAST	33
Transmembraneⁱ	168 – 188	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	208 – 231	HelicalSequence analysisAdd BLAST	24

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000184160

OpenTargetsⁱ

ENSG00000184160

PTM / Processingⁱ

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	D6RGL0
PRIDEⁱ	D6RGL0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000184160 Expressed in 213 organ(s), highest expression level in decidua
ExpressionAtlasⁱ	D6RGL0 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	D6RGL0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	68 – 249	G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST		182

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139331
HOGENOMⁱ	HOG000239242

Family and domain databases

InterProⁱ	View protein in InterPro IPR002233 ADR_fam IPR000735 ADRA2C_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24248:SF25 PTHR24248:SF25, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01103 ADRENERGICR PR00560 ADRENRGCA2CR PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

D6RGL0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASPALAAAL AVAAAAGPNA SGAGERGSGG VANASGASWG PPRGQYSAGA 
        60         70         80         90        100
VAGLAAVVGF LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV 
       110        120        130        140        150
ATLVMPFSLA NELMAYWYFG QVWCGVYLAL DVLFCTSSIV HLCAISLDRY 
       160        170        180        190        200
WSVTQAVEYN LKRTPRRVKA TIVAVWLISA VISFPPLVSL YRQPDGAAYP 
       210        220        230        240        250
QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR TRTLSEKRAP 
       260        270        280        290        300
VGPDGASPTT ENGLGAAAGA GENGHCAPPP ADVEPDESSA AAERRRRRGA 
       310        320        330        340        350
LRRGGRRRAG AEGGAGGADG QGAGPGAAES GALTASREWG GERGRPLCLP 
       360        370 
PSARGCFWGS LPGSSSGSPA EVWL

Length:374

Mass (Da):38,535

Last modified:July 13, 2010 - v1

Checksum:ⁱA7374543DFFD63E8

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	P18825	ADA2C_HUMAN		Alpha-2C adrenergic receptor Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor, Alpha-2C adrenoceptor, Alpha-2CAR)	ADRA2C ADRA2L2, ADRA2RL2	462	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC141928 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC141928 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000509482; ENSP00000426268; ENSG00000184160
UCSC genome browser More...UCSCⁱ	uc062uvp.1 human

Protein	Similar proteins		Species	Score	Length	Source
D6RGL0	Uncharacterized protein		MACMU		369	UniRef90_F7GMM7
ADRA2C isoform 2		PANTR		374
ADRA2C isoform 2		PONAB		374
Uncharacterized protein		NOMLE		374
Uncharacterized protein		GORGO		374
+5

Protein	Similar proteins		Species	Score	Length	Source
D6RGL0	Uncharacterized protein		MACMU		369	UniRef50_F7GMM7
ADRA2C isoform 2		PANTR		374
Uncharacterized protein		GORGO		374
ADRA2C isoform 2		PONAB		374
Uncharacterized protein		NOMLE		374
+17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC141928 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC141928 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	D6RGL0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Proteomic databases

PeptideAtlasⁱ	D6RGL0
PRIDEⁱ	D6RGL0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000509482; ENSP00000426268; ENSG00000184160
UCSCⁱ	uc062uvp.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000184160.7
HGNCⁱ	HGNC:283 ADRA2C
OpenTargetsⁱ	ENSG00000184160
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00890000139331
HOGENOMⁱ	HOG000239242

Gene expression databases

Bgeeⁱ	ENSG00000184160 Expressed in 213 organ(s), highest expression level in decidua
ExpressionAtlasⁱ	D6RGL0 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR002233 ADR_fam IPR000735 ADRA2C_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24248:SF25 PTHR24248:SF25, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01103 ADRENERGICR PR00560 ADRENRGCA2CR PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D6RGL0_HUMAN
Accessionⁱ	D6RGL0Primary (citable) accession number: D6RGL0
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 13, 2010
	Last sequence update:	July 13, 2010
	Last modified:	November 7, 2018
	This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D6RGL0 (D6RGL0_HUMAN)

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Alpha-2C adrenergic receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ