UniProtKB - D6RGL0 (D6RGL0_HUMAN)
Protein
Submitted name:
Alpha-2C adrenergic receptor
Gene
ADRA2C
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- alpha2-adrenergic receptor activity Source: InterPro
GO - Biological processi
- platelet activation Source: InterPro
- regulation of smooth muscle contraction Source: InterPro
- regulation of vasoconstriction Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: Alpha-2C adrenergic receptorImported |
Gene namesi | Name:ADRA2CImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:283 ADRA2C |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 50 – 76 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 88 – 109 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 115 – 147 | HelicalSequence analysisAdd BLAST | 33 | |
Transmembranei | 168 – 188 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 208 – 231 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Proteomic databases
jPOSTi | D6RGL0 |
PeptideAtlasi | D6RGL0 |
PRIDEi | D6RGL0 |
ProteomicsDBi | 14730 |
Expressioni
Gene expression databases
Bgeei | ENSG00000184160 Expressed in 213 organ(s), highest expression level in decidua |
ExpressionAtlasi | D6RGL0 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 249 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 182 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 246 – 374 | DisorderedSequence analysisAdd BLAST | 129 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000161707 |
HOGENOMi | HOG000239242 |
Family and domain databases
InterProi | View protein in InterPro IPR002233 ADR_fam IPR000735 ADRA2C_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24248:SF25 PTHR24248:SF25, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR01103 ADRENERGICR PR00560 ADRENRGCA2CR PR00237 GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
D6RGL0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASPALAAAL AVAAAAGPNA SGAGERGSGG VANASGASWG PPRGQYSAGA
60 70 80 90 100
VAGLAAVVGF LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV
110 120 130 140 150
ATLVMPFSLA NELMAYWYFG QVWCGVYLAL DVLFCTSSIV HLCAISLDRY
160 170 180 190 200
WSVTQAVEYN LKRTPRRVKA TIVAVWLISA VISFPPLVSL YRQPDGAAYP
210 220 230 240 250
QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR TRTLSEKRAP
260 270 280 290 300
VGPDGASPTT ENGLGAAAGA GENGHCAPPP ADVEPDESSA AAERRRRRGA
310 320 330 340 350
LRRGGRRRAG AEGGAGGADG QGAGPGAAES GALTASREWG GERGRPLCLP
360 370
PSARGCFWGS LPGSSSGSPA EVWL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketP18825 | ADA2C_HUMAN | Alpha-2C adrenergic receptor | ADRA2C ADRA2L2, ADRA2RL2 | 462 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC141928 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000509482; ENSP00000426268; ENSG00000184160 |
UCSCi | uc062uvp.1 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC141928 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
jPOSTi | D6RGL0 |
PeptideAtlasi | D6RGL0 |
PRIDEi | D6RGL0 |
ProteomicsDBi | 14730 |
Genome annotation databases
Ensembli | ENST00000509482; ENSP00000426268; ENSG00000184160 |
UCSCi | uc062uvp.1 human |
Organism-specific databases
HGNCi | HGNC:283 ADRA2C |
OpenTargetsi | ENSG00000184160 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000161707 |
HOGENOMi | HOG000239242 |
Gene expression databases
Bgeei | ENSG00000184160 Expressed in 213 organ(s), highest expression level in decidua |
ExpressionAtlasi | D6RGL0 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR002233 ADR_fam IPR000735 ADRA2C_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24248:SF25 PTHR24248:SF25, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR01103 ADRENERGICR PR00560 ADRENRGCA2CR PR00237 GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D6RGL0_HUMAN | |
Accessioni | D6RGL0Primary (citable) accession number: D6RGL0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | July 31, 2019 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |