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Protein
Submitted name:

T cell, immune regulator 1, ATPase, H+-transporting, lysosomal V0 protein A3

Gene

Tcirg1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

  • ATPase binding Source: GO_Central
  • proton-transporting ATPase activity, rotational mechanism Source: GO_Central

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • macroautophagy Source: MGI
  • protein catabolic process in the vacuole Source: MGI
  • vacuolar acidification Source: GO_Central

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-6798695 Neutrophil degranulation
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Names & Taxonomyi

Protein namesi
Submitted name:
T cell, immune regulator 1, ATPase, H+-transporting, lysosomal V0 protein A3Imported
Gene namesi
Name:Tcirg1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1350931 Tcirg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiD6RFN1

Expressioni

Gene expression databases

BgeeiENSMUSG00000001750 Expressed in 268 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiD6RFN1 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiD6RFN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000004941

Family and domain databases

InterProiView protein in InterPro
IPR002490 V-ATPase_116kDa_su
PANTHERiPTHR11629 PTHR11629, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

D6RFN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSMFRSEEV ALVQLLLPTG SAYNCVSQLA QRIRERLPET LRGRRPALRG
60 70
TGEDVYLLAG RSAAGRSDAG PT
Length:72
Mass (Da):7,775
Last modified:July 13, 2010 - v1
Checksum:i3BFE844E63B1BFF6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9JHF5Q9JHF5_MOUSE
V-type proton ATPase subunit a
Tcirg1 Oc116, mCG_3894
834Annotation score:
F6ZFB8F6ZFB8_MOUSE
V-type proton ATPase subunit a
Tcirg1
91Annotation score:
F6XRE6F6XRE6_MOUSE
V-type proton ATPase subunit a
Tcirg1
191Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133523 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000135070; ENSMUSP00000121241; ENSMUSG00000001750

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133523 Genomic DNA No translation available.

3D structure databases

SMRiD6RFN1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiD6RFN1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000135070; ENSMUSP00000121241; ENSMUSG00000001750

Organism-specific databases

MGIiMGI:1350931 Tcirg1

Phylogenomic databases

GeneTreeiENSGT00390000004941

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-6798695 Neutrophil degranulation
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001750 Expressed in 268 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiD6RFN1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002490 V-ATPase_116kDa_su
PANTHERiPTHR11629 PTHR11629, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD6RFN1_MOUSE
AccessioniPrimary (citable) accession number: D6RFN1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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