UniProtKB - D6RFL4 (D6RFL4_HUMAN)

BLAST

>tr|D6RFL4|D6RFL4_HUMAN Monocyte differentiation antigen CD14 (Fragment) OS=Homo sapiens OX=9606 GN=CD14 PE=1 SV=1
MERASCLLLLLLPLVHVSATTPEPCELDDEDFRCVCNFSEPQPDWSEAFQCVSAVEVEIH
AGGLNLEPFLKRVDADADPRQYADTVKALRVRRLTVGAAQVPAQLLVGALRVLAYSRLKE
LTLEDLKITGTMPPLPLEATGLALSSLRLRNVSWATGRSWLAELQQWLKPGLKVLSIAQA
HSPAFSCEQVRAFPALTSLDLSDNPGLGERGLM

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History
Entry version 52 (12 Sep 2018)
Sequence version 1 (13 Jul 2010)
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Protein

Submitted name:

Monocyte differentiation antigen CD14

Gene

CD14

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Monocyte differentiation antigen CD14Imported
Gene namesⁱ	Name:CD14Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170458.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1628 CD14

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000170458

OpenTargetsⁱ

ENSG00000170458

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_5003087424	20 – 213	Sequence analysisAdd BLAST		194

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	D6RFL4
PRIDEⁱ	D6RFL4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000170458 Expressed in 214 organ(s), highest expression level in liver
ExpressionAtlasⁱ	D6RFL4 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	D6RFL4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IXG9 Eukaryota ENOG41118N2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005689
HOGENOMⁱ	HOG000237268

Family and domain databases

Gene3Dⁱ	3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR032675 LRR_dom_sf IPR016337 Monocyte_diff_Ag_CD14
PANTHERⁱ	PTHR10630 PTHR10630, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

D6RFL4-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MERASCLLLL LLPLVHVSAT TPEPCELDDE DFRCVCNFSE PQPDWSEAFQ 
        60         70         80         90        100
CVSAVEVEIH AGGLNLEPFL KRVDADADPR QYADTVKALR VRRLTVGAAQ 
       110        120        130        140        150
VPAQLLVGAL RVLAYSRLKE LTLEDLKITG TMPPLPLEAT GLALSSLRLR 
       160        170        180        190        200
NVSWATGRSW LAELQQWLKP GLKVLSIAQA HSPAFSCEQV RAFPALTSLD 
       210 
LSDNPGLGER GLM

Length:213

Mass (Da):23,313

Last modified:July 13, 2010 - v1

Checksum:ⁱ57C828B65C1A1CCF

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

P08571	CD14_HUMAN	Monocyte differentiation antigen CD... Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form]	CD14	375	Annotation score:
D6RD81	D6RD81_HUMAN	Monocyte differentiation antigen CD... Monocyte differentiation antigen CD14	CD14	55	Annotation score:
E7EVL5	E7EVL5_HUMAN	Monocyte differentiation antigen CD... Monocyte differentiation antigen CD14	CD14	81	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	213	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC116353 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC116353 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000498971; ENSP00000426543; ENSG00000170458
UCSC genome browser More...UCSCⁱ	uc063hwn.1 human

Protein	Similar proteins		Species	Score	Length	Source
D6RFL4	Monocyte differentiation antigen CD14	)	HUMAN		375	UniRef100_P08571
CD14 isoform 3 (Fragment)		PONAB		55
CD14 isoform 5 (Fragment)		PANTR		55
Monocyte differentiation antigen CD14 (Fragment)		HUMAN		81
Monocyte differentiation antigen CD14 (Fragment)		HUMAN		55

Protein	Similar proteins		Species	Score	Length	Source
D6RFL4	Monocyte differentiation antigen CD14	)	HUMAN		375	UniRef90_P08571
CD14 isoform 3 (Fragment)		PONAB		55
CD14 isoform 5 (Fragment)		PANTR		55
Uncharacterized protein		MACMU		385
Uncharacterized protein		PANPA		384
+47

Protein	Similar proteins		Species	Score	Length	Source
D6RFL4	Monocyte differentiation antigen CD14	)	HUMAN		375	UniRef50_P08571
CD14 isoform 3 (Fragment)		PONAB		55
CD14 isoform 5 (Fragment)		PANTR		55
Uncharacterized protein		MACMU		385
Uncharacterized protein		PAPAN		384
+67

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC116353 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC116353 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	D6RFL4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlasⁱ	D6RFL4
PRIDEⁱ	D6RFL4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000498971; ENSP00000426543; ENSG00000170458
UCSCⁱ	uc063hwn.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170458.13
HGNCⁱ	HGNC:1628 CD14
OpenTargetsⁱ	ENSG00000170458
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IXG9 Eukaryota ENOG41118N2 LUCA
GeneTreeⁱ	ENSGT00390000005689
HOGENOMⁱ	HOG000237268

Miscellaneous databases

ChiTaRSⁱ	CD14 human

ChiTaRSⁱ

CD14 human

Gene expression databases

Bgeeⁱ	ENSG00000170458 Expressed in 214 organ(s), highest expression level in liver
ExpressionAtlasⁱ	D6RFL4 baseline and differential

Family and domain databases

Gene3Dⁱ	3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR032675 LRR_dom_sf IPR016337 Monocyte_diff_Ag_CD14
PANTHERⁱ	PTHR10630 PTHR10630, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D6RFL4_HUMAN
Accessionⁱ	D6RFL4Primary (citable) accession number: D6RFL4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 13, 2010
	Last sequence update:	July 13, 2010
	Last modified:	September 12, 2018
	This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - D6RFL4 (D6RFL4_HUMAN)

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Monocyte differentiation antigen CD14

CD14

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ