UniProtKB - D6RFJ0 (D6RFJ0_HUMAN)
Protein
Calcium/calmodulin-dependent protein kinase
Gene
CAMK2A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- calmodulin-dependent protein kinase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Calmodulin-bindingARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
SignaLinki | D6RFJ0 |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium/calmodulin-dependent protein kinaseARBA annotation (EC:2.7.11.17ARBA annotation) |
Gene namesi | Name:CAMK2AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000070808.15 |
HGNCi | HGNC:1460, CAMK2A |
Expressioni
Gene expression databases
Bgeei | ENSG00000070808, Expressed in right frontal lobe and 154 other tissues |
ExpressionAtlasi | D6RFJ0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 271 | Protein kinaseInterPro annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 311 – 341 | DisorderedSequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 322 – 341 | PolyampholyteSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000155150 |
HOGENOMi | CLU_188764_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR013543, Ca/CaM-dep_prot_kinase-assoc IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF08332, CaMKII_AD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
D6RFJ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS
60 70 80 90 100
ARDHQKLERE ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED
110 120 130 140 150
IVAREYYSEA DASHCIQQIL EAVLHCHQMG VVHRDLKPEN LLLASKLKGA
160 170 180 190 200
AVKLADFGLA IEVEGEQQAW FGFAGTPGYL SPEVLRKDPY GKPVDLWACG
210 220 230 240 250
VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV TPEAKDLINK
260 270 280 290 300
MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK
310 320 330 340 350
GAILTTMLAT RNFSGGKSGG NKKSDGVKES SESTNTTIED EDTKVRKQEI
360 370 380 390 400
IKVTEQLIEA ISNGDFESYT VVPEQQARAH HHPESPHPPD GRRVSLHRLH
410 420 430 440 450
PHHAVPGRWR HPTHRPVGGD PCLAPPGWQM ADRPLPQIWG ALRPAPLRDQ
460 470 480 490 500
AGVAALLCRR DPLCPWSGAA GSPRWILLEF SHVITPPPSL LYLHQENLLV
510 520 530 540
HKSHRNFRAN GHISPPLTPT LSPARLGLPQ AWVSTALAPS PQPQLLSA
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UQM7 | KCC2A_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2A CAMKA, KIAA0968 | 478 | Annotation score: | ||
A0A5F9ZH21 | A0A5F9ZH21_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2A | 478 | Annotation score: | ||
A0A5F9ZH50 | A0A5F9ZH50_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2A | 559 | Annotation score: | ||
A0A5F9ZHM9 | A0A5F9ZHM9_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2A | 467 | Annotation score: | ||
A0A5F9ZHR5 | A0A5F9ZHR5_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2A | 489 | Annotation score: | ||
A0A5K1VW76 | A0A5K1VW76_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2A | 421 | Annotation score: | ||
A0A5F9ZHY2 | A0A5F9ZHY2_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2A | 362 | Annotation score: | ||
A0A5F9ZH90 | A0A5F9ZH90_HUMAN | Calcium/calmodulin-dependent protei... | CAMK2A | 287 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011372 Genomic DNA No translation available. KF458035 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000510347; ENSP00000426607; ENSG00000070808 |
UCSCi | uc063iqq.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011372 Genomic DNA No translation available. KF458035 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | D6RFJ0 |
PRIDEi | D6RFJ0 |
ProteomicsDBi | 14546 |
Protocols and materials databases
Antibodypediai | 3814, 847 antibodies |
Genome annotation databases
Ensembli | ENST00000510347; ENSP00000426607; ENSG00000070808 |
UCSCi | uc063iqq.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000070808.15 |
HGNCi | HGNC:1460, CAMK2A |
OpenTargetsi | ENSG00000070808 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155150 |
HOGENOMi | CLU_188764_0_0_1 |
Enzyme and pathway databases
SignaLinki | D6RFJ0 |
Miscellaneous databases
ChiTaRSi | CAMK2A, human |
Gene expression databases
Bgeei | ENSG00000070808, Expressed in right frontal lobe and 154 other tissues |
ExpressionAtlasi | D6RFJ0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR013543, Ca/CaM-dep_prot_kinase-assoc IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF08332, CaMKII_AD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D6RFJ0_HUMAN | |
Accessioni | D6RFJ0Primary (citable) accession number: D6RFJ0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 13, 2010 |
Last sequence update: | December 11, 2019 | |
Last modified: | October 7, 2020 | |
This is version 79 of the entry and version 9 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |