UniProtKB - D6RFG5 (D6RFG5_HUMAN)
Protein
Annexin
Gene
ANXA3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: UniProtKB-KW
- calcium ion binding Source: InterPro
- phospholipase inhibitor activity Source: InterPro
Keywordsi
Ligand | Calcium, Calcium/phospholipid-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: AnnexinUniRule annotation |
Gene namesi | Name:ANXA3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138772.12 |
HGNCi | HGNC:541, ANXA3 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
PTM / Processingi
Proteomic databases
MaxQBi | D6RFG5 |
PeptideAtlasi | D6RFG5 |
PRIDEi | D6RFG5 |
ProteomicsDBi | 14523 |
Expressioni
Gene expression databases
Bgeei | ENSG00000138772, Expressed in bone marrow and 218 other tissues |
ExpressionAtlasi | D6RFG5, baseline and differential |
Family & Domainsi
Domaini
A pair of annexin repeats may form one binding site for calcium and phospholipid.UniRule annotation
Sequence similaritiesi
Keywords - Domaini
AnnexinUniRule annotationARBA annotation, RepeatUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159174 |
HOGENOMi | CLU_025300_2_0_1 |
Family and domain databases
Gene3Di | 1.10.220.10, 2 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR002390, ANX3 |
PANTHERi | PTHR10502:SF25, PTHR10502:SF25, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 2 hits |
PRINTSi | PR00196, ANNEXIN PR00199, ANNEXINIII |
SMARTi | View protein in SMART SM00335, ANX, 2 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 1 hit PS51897, ANNEXIN_2, 2 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
D6RFG5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASIWVGHRG TVRDYPDFSP SVDAEAIQKA IRGIGTDEKM LISILTERSN
60 70 80 90 100
AQRQLIVKEY QAAYGKELKD DLKGDLSGHF EHLMVALVTP PAVFDAKQLK
110 120 130 140 150
KSMKGAGTNE DALIEILTTR TSRQMKDISQ AYYTVYKKSL GDDISSETSG
DFRK
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP12429 | ANXA3_HUMAN | Annexin A3 | ANXA3 ANX3 | 323 | Annotation score: | ||
D6RAZ8 | D6RAZ8_HUMAN | Annexin | ANXA3 | 104 | Annotation score: | ||
D6RCA8 | D6RCA8_HUMAN | Annexin | ANXA3 | 134 | Annotation score: | ||
D6RA82 | D6RA82_HUMAN | Annexin | ANXA3 | 284 | Annotation score: | ||
D6RFJ9 | D6RFJ9_HUMAN | Annexin A3 | ANXA3 | 55 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 154 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104808 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000514171; ENSP00000421512; ENSG00000138772 |
UCSCi | uc062xpa.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104808 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | D6RFG5 |
PeptideAtlasi | D6RFG5 |
PRIDEi | D6RFG5 |
ProteomicsDBi | 14523 |
Protocols and materials databases
Antibodypediai | 2890, 572 antibodies |
Genome annotation databases
Ensembli | ENST00000514171; ENSP00000421512; ENSG00000138772 |
UCSCi | uc062xpa.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138772.12 |
HGNCi | HGNC:541, ANXA3 |
OpenTargetsi | ENSG00000138772 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159174 |
HOGENOMi | CLU_025300_2_0_1 |
Miscellaneous databases
ChiTaRSi | ANXA3, human |
Gene expression databases
Bgeei | ENSG00000138772, Expressed in bone marrow and 218 other tissues |
ExpressionAtlasi | D6RFG5, baseline and differential |
Family and domain databases
Gene3Di | 1.10.220.10, 2 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR002390, ANX3 |
PANTHERi | PTHR10502:SF25, PTHR10502:SF25, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 2 hits |
PRINTSi | PR00196, ANNEXIN PR00199, ANNEXINIII |
SMARTi | View protein in SMART SM00335, ANX, 2 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 1 hit PS51897, ANNEXIN_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D6RFG5_HUMAN | |
Accessioni | D6RFG5Primary (citable) accession number: D6RFG5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | December 2, 2020 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |