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Protein
Submitted name:

Long-chain-fatty-acid--CoA ligase 4

Gene

ACSL4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Long-chain-fatty-acid--CoA ligase 4Imported
Gene namesi
Name:ACSL4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000068366.19
HGNCiHGNC:3571 ACSL4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000068366

PTM / Processingi

Proteomic databases

MaxQBiD6RF95
PeptideAtlasiD6RF95
PRIDEiD6RF95

Expressioni

Gene expression databases

BgeeiENSG00000068366 Expressed in 215 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiD6RF95 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliD6RF95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 153AMP-bindingInterPro annotationAdd BLAST78

Phylogenomic databases

eggNOGiKOG1256 Eukaryota
COG1022 LUCA
GeneTreeiENSGT00930000150966

Family and domain databases

InterProiView protein in InterPro
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

D6RF95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKRIKAKPT SDKPGSPYRS VTHFDSLAVI DIPGADTLDK LFDHAVSKFG
60 70 80 90 100
KKDSLGTREI LSEENEMQPN GKVFKKLILG NYKWMNYLEV NRRVNNFGSG
110 120 130 140 150
LTALGLKPKN TIAIFCETRA EWMIAAQTCF KYNFPLVTLY ATLGKEAVVH

GLNE
Length:154
Mass (Da):17,242
Last modified:July 13, 2010 - v1
Checksum:iFB7548C92CD7FD07
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O60488ACSL4_HUMAN
Long-chain-fatty-acid--CoA ligase 4
ACSL4 ACS4, FACL4, LACS4
711Annotation score:
D6RFW9D6RFW9_HUMAN
Long-chain-fatty-acid--CoA ligase 4
ACSL4
126Annotation score:
D6RD96D6RD96_HUMAN
Long-chain-fatty-acid--CoA ligase 4
ACSL4
145Annotation score:
D6RDA8D6RDA8_HUMAN
Long-chain-fatty-acid--CoA ligase 4
ACSL4
128Annotation score:
A0A0C4DGB7A0A0C4DGB7_HUMAN
Long-chain-fatty-acid--CoA ligase 4
ACSL4
54Annotation score:
H0Y9A0H0Y9A0_HUMAN
Long-chain-fatty-acid--CoA ligase 4
ACSL4
156Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei154Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL118496 Genomic DNA No translation available.
AL138968 Genomic DNA No translation available.
KF459310 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000505855; ENSP00000424808; ENSG00000068366
UCSCiuc065are.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL118496 Genomic DNA No translation available.
AL138968 Genomic DNA No translation available.
KF459310 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliD6RF95
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiD6RF95
PeptideAtlasiD6RF95
PRIDEiD6RF95

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000505855; ENSP00000424808; ENSG00000068366
UCSCiuc065are.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000068366.19
HGNCiHGNC:3571 ACSL4
OpenTargetsiENSG00000068366
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1256 Eukaryota
COG1022 LUCA
GeneTreeiENSGT00930000150966

Miscellaneous databases

ChiTaRSiACSL4 human

Gene expression databases

BgeeiENSG00000068366 Expressed in 215 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiD6RF95 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD6RF95_HUMAN
AccessioniPrimary (citable) accession number: D6RF95
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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