UniProtKB - D6RF93 (D6RF93_HUMAN)
Protein
Submitted name:
Nuclear factor NF-kappa-B p105 subunit
Gene
NFKB1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: InterPro
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Nuclear factor NF-kappa-B p105 subunitImported |
Gene namesi | Name:NFKB1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7794, NFKB1 |
VEuPathDBi | HostDB:ENSG00000109320.11 |
Subcellular locationi
PTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
MaxQBi | D6RF93 |
PeptideAtlasi | D6RF93 |
PRIDEi | D6RF93 |
ProteomicsDBi | 14498 |
Expressioni
Gene expression databases
Bgeei | ENSG00000109320, Expressed in bone marrow and 212 other tissues |
ExpressionAtlasi | D6RF93, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 40 | RHDInterPro annotationAdd BLAST | 40 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 154 – 196 | DisorderedSequence analysisAdd BLAST | 43 |
Phylogenomic databases
GeneTreei | ENSGT00940000158625 |
HOGENOMi | CLU_004343_0_0_1 |
Family and domain databases
CDDi | cd01177, IPT_NFkappaB, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR030503, NF-kB_p105 IPR000451, NFkB/Dor IPR008967, p53-like_TF_DNA-bd IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169, PTHR24169, 1 hit PTHR24169:SF9, PTHR24169:SF9, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR00057, NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
D6RF93-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLSVVRLMF TAFLPDSTGS FTRRLEPVVS DAIYDSKAPN ASNLKIVRMD
60 70 80 90 100
RTAGCVTGGE EIYLLCDKVQ KDDIQIRFYE EEENGGVWEG FGDFSPTDVH
110 120 130 140 150
RQFAIVFKTP KYKDINITKP ASVFVQLRRK SDLETSEPKP FLYYPEIKDK
160 170 180 190
EEVQRKRQKL MPNFSDSFGG GSGAGAGGGG MFGSGGGGGG TGSTGP
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP19838 | NFKB1_HUMAN | Nuclear factor NF-kappa-B p105 subu... | NFKB1 | 968 | Annotation score: | ||
A0A494C1E9 | A0A494C1E9_HUMAN | Nuclear factor NF-kappa-B p105 subu... | NFKB1 | 511 | Annotation score: | ||
D6RH30 | D6RH30_HUMAN | Nuclear factor NF-kappa-B p105 subu... | NFKB1 | 198 | Annotation score: | ||
D6RDI9 | D6RDI9_HUMAN | Nuclear factor NF-kappa-B p105 subu... | NFKB1 | 74 | Annotation score: | ||
D6RC45 | D6RC45_HUMAN | Nuclear factor NF-kappa-B p105 subu... | NFKB1 | 144 | Annotation score: | ||
A0A494C157 | A0A494C157_HUMAN | Nuclear factor NF-kappa-B p105 subu... | NFKB1 | 253 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 196 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF213884 Genomic DNA No translation available. KF457798 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000508584; ENSP00000424815; ENSG00000109320 |
UCSCi | uc062yor.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF213884 Genomic DNA No translation available. KF457798 Genomic DNA No translation available. |
3D structure databases
SMRi | D6RF93 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | D6RF93, 1 interactor |
MINTi | D6RF93 |
Proteomic databases
MaxQBi | D6RF93 |
PeptideAtlasi | D6RF93 |
PRIDEi | D6RF93 |
ProteomicsDBi | 14498 |
Protocols and materials databases
Antibodypediai | 3415, 2359 antibodies |
Genome annotation databases
Ensembli | ENST00000508584; ENSP00000424815; ENSG00000109320 |
UCSCi | uc062yor.1, human |
Organism-specific databases
HGNCi | HGNC:7794, NFKB1 |
OpenTargetsi | ENSG00000109320 |
VEuPathDBi | HostDB:ENSG00000109320.11 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158625 |
HOGENOMi | CLU_004343_0_0_1 |
Miscellaneous databases
ChiTaRSi | NFKB1, human |
Gene expression databases
Bgeei | ENSG00000109320, Expressed in bone marrow and 212 other tissues |
ExpressionAtlasi | D6RF93, baseline and differential |
Family and domain databases
CDDi | cd01177, IPT_NFkappaB, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR030503, NF-kB_p105 IPR000451, NFkB/Dor IPR008967, p53-like_TF_DNA-bd IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169, PTHR24169, 1 hit PTHR24169:SF9, PTHR24169:SF9, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR00057, NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D6RF93_HUMAN | |
Accessioni | D6RF93Primary (citable) accession number: D6RF93 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | April 7, 2021 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |