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Protein
Submitted name:

Alpha-adducin

Gene

ADD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-adducinImported
Gene namesi
Name:ADD1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000087274.16
HGNCiHGNC:243 ADD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000087274

PTM / Processingi

Proteomic databases

PeptideAtlasiD6RF25
PRIDEiD6RF25

Expressioni

Gene expression databases

BgeeiENSG00000087274 Expressed in 239 organ(s), highest expression level in fundus of stomach
ExpressionAtlasiD6RF25 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliD6RF25
SMRiD6RF25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 141Aldolase_IIInterPro annotationAdd BLAST73

Phylogenomic databases

eggNOGiKOG3699 Eukaryota
COG0235 LUCA
GeneTreeiENSGT00390000016462
HOGENOMiHOG000180645

Family and domain databases

Gene3Di3.40.225.10, 1 hit
InterProiView protein in InterPro
IPR027766 ADD1
IPR001303 Aldolase_II/adducin_N
IPR036409 Aldolase_II/adducin_N_sf
PANTHERiPTHR10672:SF4 PTHR10672:SF4, 2 hits
PfamiView protein in Pfam
PF00596 Aldolase_II, 1 hit
SUPFAMiSSF53639 SSF53639, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

D6RF25-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN
60 70 80 90 100
MMEQKKRVSM ILQSPTRVNS EQEHFLIVPF GLLYSEVTAS SLVKINLQGD
110 120 130 140
IVDRGSTNLG VNQAGFTLHS AIYAARPDVK CVVHIHTPAG AA
Length:142
Mass (Da):15,806
Last modified:October 5, 2016 - v8
Checksum:i276D29FF3E81E399
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P35611ADDA_HUMAN
Alpha-adducin
ADD1 ADDA
737Annotation score:
H0Y9H2H0Y9H2_HUMAN
Alpha-adducin
ADD1
444Annotation score:
E7EV99E7EV99_HUMAN
Alpha-adducin
ADD1
632Annotation score:
E7ENY0E7ENY0_HUMAN
Alpha-adducin
ADD1
663Annotation score:
H0YG19H0YG19_HUMAN
Alpha-adducin
ADD1
114Annotation score:
A0A0A0MSR2A0A0A0MSR2_HUMAN
Alpha-adducin
ADD1
400Annotation score:
D6RJE2D6RJE2_HUMAN
Alpha-adducin
ADD1
69Annotation score:
H0YFD8H0YFD8_HUMAN
Alpha-adducin
ADD1
105Annotation score:
D6RAH3D6RAH3_HUMAN
Alpha-adducin
ADD1
137Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei142Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121750 Genomic DNA No translation available.
AL390065 Genomic DNA No translation available.
BX465861 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000508277; ENSP00000426700; ENSG00000087274
UCSCiuc062usa.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121750 Genomic DNA No translation available.
AL390065 Genomic DNA No translation available.
BX465861 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliD6RF25
SMRiD6RF25
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiD6RF25
PRIDEiD6RF25

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000508277; ENSP00000426700; ENSG00000087274
UCSCiuc062usa.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000087274.16
HGNCiHGNC:243 ADD1
OpenTargetsiENSG00000087274
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3699 Eukaryota
COG0235 LUCA
GeneTreeiENSGT00390000016462
HOGENOMiHOG000180645

Miscellaneous databases

ChiTaRSiADD1 human

Gene expression databases

BgeeiENSG00000087274 Expressed in 239 organ(s), highest expression level in fundus of stomach
ExpressionAtlasiD6RF25 baseline and differential

Family and domain databases

Gene3Di3.40.225.10, 1 hit
InterProiView protein in InterPro
IPR027766 ADD1
IPR001303 Aldolase_II/adducin_N
IPR036409 Aldolase_II/adducin_N_sf
PANTHERiPTHR10672:SF4 PTHR10672:SF4, 2 hits
PfamiView protein in Pfam
PF00596 Aldolase_II, 1 hit
SUPFAMiSSF53639 SSF53639, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD6RF25_HUMAN
AccessioniPrimary (citable) accession number: D6RF25
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 61 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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