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Protein
Submitted name:

Methionine synthase reductase

Gene

MTRR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Methionine synthase reductaseImported
Gene namesi
Name:MTRRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000124275.14
HGNCiHGNC:7473 MTRR

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124275

PTM / Processingi

Proteomic databases

MaxQBiD6RF21
PeptideAtlasiD6RF21

Expressioni

Gene expression databases

BgeeiENSG00000124275 Expressed in 223 organ(s), highest expression level in corpus callosum
ExpressionAtlasiD6RF21 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliD6RF21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 92Flavodoxin-likeInterPro annotationAdd BLAST89

Phylogenomic databases

eggNOGiKOG1158 Eukaryota
COG0369 LUCA
GeneTreeiENSGT00920000149089

Family and domain databases

Gene3Di3.40.50.360, 1 hit
InterProiView protein in InterPro
IPR008254 Flavodoxin/NO_synth
IPR029039 Flavoprotein-like_sf
PfamiView protein in Pfam
PF00258 Flavodoxin_1, 1 hit
SUPFAMiSSF52218 SSF52218, 1 hit
PROSITEiView protein in PROSITE
PS50902 FLAVODOXIN_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

D6RF21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRFLLLYAT QQGQAKAIAE EICEQAVVHG FSADLHCISE SDKYDLKTET
60 70 80 90
APLVVVVSTT GTGDPPDTAR KFVKEIQNQT LPVDFFAHLR SR
Length:92
Mass (Da):10,251
Last modified:July 13, 2010 - v1
Checksum:i8E532E011921438B
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UBK8MTRR_HUMAN
Methionine synthase reductase
MTRR
725Annotation score:
H0Y8S9H0Y8S9_HUMAN
Methionine synthase reductase
MTRR
372Annotation score:
D6RAZ2D6RAZ2_HUMAN
Methionine synthase reductase
MTRR
156Annotation score:
D6RGC7D6RGC7_HUMAN
Methionine synthase reductase
MTRR
112Annotation score:
D6RIS8D6RIS8_HUMAN
Methionine synthase reductase
MTRR
41Annotation score:
D6RAY3D6RAY3_HUMAN
Methionine synthase reductase
MTRR
46Annotation score:
H0Y963H0Y963_HUMAN
Methionine synthase reductase
MTRR
115Annotation score:
H0Y9D5H0Y9D5_HUMAN
Methionine synthase reductase
MTRR
160Annotation score:
H0Y9Q0H0Y9Q0_HUMAN
Methionine synthase reductase
MTRR
81Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010346 Genomic DNA No translation available.
AC025174 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000513439; ENSP00000426710; ENSG00000124275
UCSCiuc063cej.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010346 Genomic DNA No translation available.
AC025174 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliD6RF21
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiD6RF21
PeptideAtlasiD6RF21

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000513439; ENSP00000426710; ENSG00000124275
UCSCiuc063cej.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000124275.14
HGNCiHGNC:7473 MTRR
OpenTargetsiENSG00000124275
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1158 Eukaryota
COG0369 LUCA
GeneTreeiENSGT00920000149089

Gene expression databases

BgeeiENSG00000124275 Expressed in 223 organ(s), highest expression level in corpus callosum
ExpressionAtlasiD6RF21 baseline and differential

Family and domain databases

Gene3Di3.40.50.360, 1 hit
InterProiView protein in InterPro
IPR008254 Flavodoxin/NO_synth
IPR029039 Flavoprotein-like_sf
PfamiView protein in Pfam
PF00258 Flavodoxin_1, 1 hit
SUPFAMiSSF52218 SSF52218, 1 hit
PROSITEiView protein in PROSITE
PS50902 FLAVODOXIN_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD6RF21_HUMAN
AccessioniPrimary (citable) accession number: D6RF21
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: September 12, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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