UniProtKB - D6REX3 (D6REX3_HUMAN)
Protein
Submitted name:
Protein transport protein Sec31A
Gene
SEC31A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: InterPro
Keywordsi
Biological process | ER-Golgi transportARBA annotation, Transport |
Enzyme and pathway databases
SignaLinki | D6REX3 |
Names & Taxonomyi
Protein namesi | Submitted name: Protein transport protein Sec31AImported |
Gene namesi | Name:SEC31AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138674.16 |
HGNCi | HGNC:17052, SEC31A |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotationPTM / Processingi
Proteomic databases
EPDi | D6REX3 |
MaxQBi | D6REX3 |
PeptideAtlasi | D6REX3 |
PRIDEi | D6REX3 |
ProteomicsDBi | 14392 |
Expressioni
Gene expression databases
Bgeei | ENSG00000138674, Expressed in pituitary gland and 247 other tissues |
ExpressionAtlasi | D6REX3, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 118 – 341 | WD_REPEATS_REGIONInterPro annotationAdd BLAST | 224 | |
Repeati | 118 – 160 | WDPROSITE-ProRule annotationAdd BLAST | 43 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 791 – 822 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 845 – 939 | DisorderedSequence analysisAdd BLAST | 95 | |
Regioni | 955 – 1127 | DisorderedSequence analysisAdd BLAST | 173 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1171 – 1191 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 845 – 862 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 896 – 912 | Pro-richSequence analysisAdd BLAST | 17 | |
Compositional biasi | 955 – 969 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1010 – 1027 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1057 – 1087 | PolarSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the WD repeat SEC31 family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, WD repeatPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000003175 |
OMAi | FMIAICG |
PhylomeDBi | D6REX3 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR024298, ACE1_Sec16_Sec31 IPR040251, SEC31-like IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR13923, PTHR13923, 1 hit |
Pfami | View protein in Pfam PF12931, Sec16_C, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 19 potential isoforms that are computationally mapped.Show allAlign All
D6REX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLKEVDRTA MQAWSPAQNH PIYLATGTSA QQLDATFSTN ASLEIFELDL
60 70 80 90 100
SDPSLDMKSC ATFSSSHRYH KLIWGPYKMD SKGDVSGVLI AGGENGNIIL
110 120 130 140 150
YDPSKIIAGD KEVVIAQNDK HTGPVRALDV NIFQTNLVAS GANESEIYIW
160 170 180 190 200
DLNNFATPMT PGAKTQPPED ISCIAWNRQV QHILASASPS GRATVWDLRK
210 220 230 240 250
NEPIIKVSDH SNRMHCSGLA WHPDVATQMV LASEDDRLPV IQMWDLRFAS
260 270 280 290 300
SPLRVLENHA RGILAIAWSM ADPELLLSCG KDAKILCSNP NTGEVLYELP
310 320 330 340 350
TNTQWCFDIQ WCPRNPAVLS AASFDGRISV YSIMGGSTDG LRQKQVDKLS
360 370 380 390 400
SSFGNLDPFG TGQPLPPLQI PQQTAQHSIV LPLKKPPKWI RRPVGASFSF
410 420 430 440 450
GGKLVTFENV RMPSHQGAEQ QQQQHHVFIS QVVTEKEFLS RSDQLQQAVQ
460 470 480 490 500
SQGFINYCQK KIDASQTEFE KNVWSFLKVN FEDDSRGKYL ELLGYRKEDL
510 520 530 540 550
GKKIALALNK VDGANVALKD SDQVAQSDGE ESPAAEEQLL GEHIKEEKEE
560 570 580 590 600
SEFLPSSGGT FNISVSGDID GLITQALLTG NFESAVDLCL HDNRMADAII
610 620 630 640 650
LAIAGGQELL ARTQKKYFAK SQSKITRLIT AVVMKNWKEI VESCDLKNWR
660 670 680 690 700
EALAAVLTYA KPDEFSALCD LLGTRLENEG DSLLQTQACL CYICAGNVEK
710 720 730 740 750
LVACWTKAQD GSHPLSLQDL IEKVVILRKA VQLTQAMDTS TVGVLLAAKM
760 770 780 790 800
SQYANLLAAQ GSIAAALAFL PDNTNQPNIM QLRDRLCRAQ GEPVAGHESP
810 820 830 840 850
KIPYEKQQLP KGRPGPVAGH HQMPRVQTQQ YYPHVRIAPT VTTWSNKTPT
860 870 880 890 900
ALPSHPPAAS PSDTQGENPP PPGFIMHGNV NPNAAGQLPT SPGHMHTQVP
910 920 930 940 950
PYPQPQPYQP AQPYPFGTGG SAMYRPQQPV APPTSNAYPN TPYISSASSY
960 970 980 990 1000
TGQSQLYAAQ HQASSPTSSP ATSFPPPPSS GASFQHGGPG APPSSSAYAL
1010 1020 1030 1040 1050
PPGTTGTLPA ASELPASQRT GPQNGWNDPP ALNRVPKKKK MPENFMPPVP
1060 1070 1080 1090 1100
ITSPIMNPLG DPQSQMLQQQ PSAPVPLSSQ SSFPQPHLPG GQPFHGVQQP
1110 1120 1130 1140 1150
LGQTGMPPSF SKPNIEGAPG APIGNTFQHV QSLPTKKITK KPIPDEHLIL
1160 1170 1180 1190 1200
KTTFEDLIQR CLSSATDPQT KRKLDDASKR LEFLYDKLRE QTLSPTITSG
1210 1220 1230 1240 1250
LHNIARSIET RNYSEGLTMH THIVSTSNFS ETSAFMPVLK VVLTQANKLG
V
Computationally mapped potential isoform sequencesi
There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO94979 | SC31A_HUMAN | Protein transport protein Sec31A | SEC31A KIAA0905, SEC31L1, HSPC275, HSPC334 | 1,220 | Annotation score: | ||
H7BXG7 | H7BXG7_HUMAN | Protein transport protein Sec31A | SEC31A | 969 | Annotation score: | ||
D6RHZ5 | D6RHZ5_HUMAN | Protein transport protein Sec31A | SEC31A | 877 | Annotation score: | ||
H0YAB3 | H0YAB3_HUMAN | Protein transport protein Sec31A | SEC31A | 443 | Annotation score: | ||
H0Y9T9 | H0Y9T9_HUMAN | Protein transport protein Sec31A | SEC31A | 235 | Annotation score: | ||
H0Y8W8 | H0Y8W8_HUMAN | Protein transport protein Sec31A | SEC31A | 383 | Annotation score: | ||
D6RCQ9 | D6RCQ9_HUMAN | Protein transport protein Sec31A | SEC31A | 166 | Annotation score: | ||
D6RE64 | D6RE64_HUMAN | Protein transport protein Sec31A | SEC31A | 164 | Annotation score: | ||
H0Y9V3 | H0Y9V3_HUMAN | Protein transport protein Sec31A | SEC31A | 219 | Annotation score: | ||
H0YAF5 | H0YAF5_HUMAN | Protein transport protein Sec31A | SEC31A | 181 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021105 Genomic DNA No translation available. AC108469 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000505472; ENSP00000421633; ENSG00000138674 |
UCSCi | uc062xtf.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021105 Genomic DNA No translation available. AC108469 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | D6REX3, 3 interactors |
Proteomic databases
EPDi | D6REX3 |
MaxQBi | D6REX3 |
PeptideAtlasi | D6REX3 |
PRIDEi | D6REX3 |
ProteomicsDBi | 14392 |
Protocols and materials databases
Antibodypediai | 1692, 135 antibodies |
Genome annotation databases
Ensembli | ENST00000505472; ENSP00000421633; ENSG00000138674 |
UCSCi | uc062xtf.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138674.16 |
HGNCi | HGNC:17052, SEC31A |
OpenTargetsi | ENSG00000138674 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000003175 |
OMAi | FMIAICG |
PhylomeDBi | D6REX3 |
Enzyme and pathway databases
SignaLinki | D6REX3 |
Miscellaneous databases
ChiTaRSi | SEC31A, human |
Gene expression databases
Bgeei | ENSG00000138674, Expressed in pituitary gland and 247 other tissues |
ExpressionAtlasi | D6REX3, baseline and differential |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR024298, ACE1_Sec16_Sec31 IPR040251, SEC31-like IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR13923, PTHR13923, 1 hit |
Pfami | View protein in Pfam PF12931, Sec16_C, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D6REX3_HUMAN | |
Accessioni | D6REX3Primary (citable) accession number: D6REX3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | December 2, 2020 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |