UniProtKB - D6REX0 (D6REX0_HUMAN)
Protein
Submitted name:
A disintegrin and metalloproteinase with thrombospondin motifs 12
Gene
ADAMTS12
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: A disintegrin and metalloproteinase with thrombospondin motifs 12Imported |
Gene namesi | Name:ADAMTS12Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000151388.10 |
HGNCi | HGNC:14605, ADAMTS12 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_5003087765 | 28 – 232 | Sequence analysisAdd BLAST | 205 |
Proteomic databases
PeptideAtlasi | D6REX0 |
PRIDEi | D6REX0 |
ProteomicsDBi | 14389 |
Expressioni
Gene expression databases
Bgeei | ENSG00000151388, Expressed in adrenal tissue and 128 other tissues |
ExpressionAtlasi | D6REX0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 195 | Pep_M12B_propepInterPro annotationAdd BLAST | 142 |
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155855 |
HOGENOMi | CLU_104239_0_0_1 |
OrthoDBi | 1229120at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR002870, Peptidase_M12B_N |
Pfami | View protein in Pfam PF01562, Pep_M12B_propep, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
D6REX0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPCAQRSWLA NLSVVAQLLN FGALCYGRQP QPGPVRFPDR RQEHFIKGLP
60 70 80 90 100
EYHVVGPVRV DASGHFLSYG LHYPITSSRR KRDLDGSEDW VYYRISHEEK
110 120 130 140 150
DLFFNLTVNQ GFLSNSYIME KRYGNLSHVK MMASSAPLCH LSGTVLQQGT
160 170 180 190 200
RVGTAALSAC HGLTGFFQLP HGDFFIEPVK KHPLVEGGYH PHIVYRRQKV
210 220 230
PETKEPTCGL KGIVTHMSSW VEESVLFFWL FY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP58397 | ATS12_HUMAN | A disintegrin and metalloproteinase... | ADAMTS12 UNQ1918/PRO4389 | 1,594 | Annotation score: | ||
A0A0G2JRM9 | A0A0G2JRM9_HUMAN | A disintegrin and metalloproteinase... | ADAMTS12 | 163 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008880 Genomic DNA No translation available. AC034232 Genomic DNA No translation available. AC109491 Genomic DNA No translation available. AC139777 Genomic DNA No translation available. |
RefSeqi | NP_001311440.1, NM_001324511.1 |
Genome annotation databases
Ensembli | ENST00000515401; ENSP00000421638; ENSG00000151388 |
GeneIDi | 81792 |
UCSCi | uc003jib.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008880 Genomic DNA No translation available. AC034232 Genomic DNA No translation available. AC109491 Genomic DNA No translation available. AC139777 Genomic DNA No translation available. |
RefSeqi | NP_001311440.1, NM_001324511.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | D6REX0 |
PRIDEi | D6REX0 |
ProteomicsDBi | 14389 |
Protocols and materials databases
Antibodypediai | 22743, 130 antibodies |
Genome annotation databases
Ensembli | ENST00000515401; ENSP00000421638; ENSG00000151388 |
GeneIDi | 81792 |
UCSCi | uc003jib.1, human |
Organism-specific databases
CTDi | 81792 |
EuPathDBi | HostDB:ENSG00000151388.10 |
HGNCi | HGNC:14605, ADAMTS12 |
OpenTargetsi | ENSG00000151388 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155855 |
HOGENOMi | CLU_104239_0_0_1 |
OrthoDBi | 1229120at2759 |
Miscellaneous databases
BioGRID-ORCSi | 81792, 6 hits in 844 CRISPR screens |
ChiTaRSi | ADAMTS12, human |
GenomeRNAii | 81792 |
Gene expression databases
Bgeei | ENSG00000151388, Expressed in adrenal tissue and 128 other tissues |
ExpressionAtlasi | D6REX0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR002870, Peptidase_M12B_N |
Pfami | View protein in Pfam PF01562, Pep_M12B_propep, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D6REX0_HUMAN | |
Accessioni | D6REX0Primary (citable) accession number: D6REX0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | December 2, 2020 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |