UniProtKB - D6REB8 (D6REB8_HUMAN)
Protein
Adenylate cyclase
Gene
ADCY2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:4.6.1.1ARBA annotation
Cofactori
Mn2+ARBA annotation
GO - Molecular functioni
- adenylate cyclase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cyclic nucleotide biosynthetic process Source: InterPro
- intracellular signal transduction Source: InterPro
Keywordsi
Molecular function | LyaseARBA annotation |
Ligand | ATP-bindingARBA annotation, MagnesiumARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ADCY2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000078295.15 |
HGNCi | HGNC:233, ADCY2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000078295, Expressed in frontal cortex and 212 other tissues |
ExpressionAtlasi | D6REB8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 79 – 100 | Guanylate cyclaseInterPro annotationAdd BLAST | 22 |
Phylogenomic databases
GeneTreei | ENSGT00940000156424 |
HOGENOMi | CLU_181156_0_0_1 |
Family and domain databases
Gene3Di | 3.30.70.1230, 1 hit |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR032628, AC_N IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF16214, AC_N, 1 hit |
SUPFAMi | SSF55073, SSF55073, 1 hit |
PROSITEi | View protein in PROSITE PS50125, GUANYLATE_CYCLASE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
D6REB8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELALQQTYQ DTCNCIKSRI KLEFEKRQQE RLLLSLLPAH IAMEMKAEII
60 70 80 90 100
QRLQGPKAGQ MENTNNFHNL YVKRHTNVSI LYADIVGFTR LASDCSPGEL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ08462 | ADCY2_HUMAN | Adenylate cyclase type 2 | ADCY2 KIAA1060 | 1,091 | Annotation score: | ||
H0YA58 | H0YA58_HUMAN | Adenylate cyclase type 2 | ADCY2 | 76 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 100 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010346 Genomic DNA No translation available. AC010437 Genomic DNA No translation available. AC024577 Genomic DNA No translation available. AC093305 Genomic DNA No translation available. AC113366 Genomic DNA No translation available. KF457856 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000515681; ENSP00000425069; ENSG00000078295 |
UCSCi | uc063cdu.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010346 Genomic DNA No translation available. AC010437 Genomic DNA No translation available. AC024577 Genomic DNA No translation available. AC093305 Genomic DNA No translation available. AC113366 Genomic DNA No translation available. KF457856 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | D6REB8 |
PRIDEi | D6REB8 |
ProteomicsDBi | 14281 |
Protocols and materials databases
Antibodypediai | 22409, 170 antibodies |
Genome annotation databases
Ensembli | ENST00000515681; ENSP00000425069; ENSG00000078295 |
UCSCi | uc063cdu.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000078295.15 |
HGNCi | HGNC:233, ADCY2 |
OpenTargetsi | ENSG00000078295 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156424 |
HOGENOMi | CLU_181156_0_0_1 |
Miscellaneous databases
ChiTaRSi | ADCY2, human |
Gene expression databases
Bgeei | ENSG00000078295, Expressed in frontal cortex and 212 other tissues |
ExpressionAtlasi | D6REB8, baseline and differential |
Family and domain databases
Gene3Di | 3.30.70.1230, 1 hit |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR032628, AC_N IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF16214, AC_N, 1 hit |
SUPFAMi | SSF55073, SSF55073, 1 hit |
PROSITEi | View protein in PROSITE PS50125, GUANYLATE_CYCLASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D6REB8_HUMAN | |
Accessioni | D6REB8Primary (citable) accession number: D6REB8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | October 7, 2020 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |