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Protein
Submitted name:

COP9 signalosome complex subunit 4

Gene

COPS4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
COP9 signalosome complex subunit 4Imported
Gene namesi
Name:COPS4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138663.8
HGNCiHGNC:16702 COPS4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000138663

PTM / Processingi

Proteomic databases

MaxQBiD6RD63
PeptideAtlasiD6RD63
PRIDEiD6RD63

Expressioni

Gene expression databases

BgeeiENSG00000138663 Expressed in 233 organ(s), highest expression level in biceps brachii
ExpressionAtlasiD6RD63 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliD6RD63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 254PCIInterPro annotationAdd BLAST170

Phylogenomic databases

eggNOGiKOG1497 Eukaryota
ENOG410XPDE LUCA
GeneTreeiENSGT00730000111161
HOGENOMiHOG000158382

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR037754 CSN4
IPR000717 PCI_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10855:SF2 PTHR10855:SF2, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

D6RD63-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAVRQDLA QLMNSSGSHK DLAGKQYNVD YKLETYLKIA RLYLEDDDPV
60 70 80 90 100
QAEAYINRAS LLQNESTNEQ LQIHYKVCYA RVLDYRRKFI EAAQRYNELS
110 120 130 140 150
YKTIVHESER LEALKHALHC TILASAGQQR SRMLATLFKD ERCQQLAAYG
160 170 180 190 200
ILEKMYLDRI IRGNQLQEFA AMLMPHQKAT TADGSSILDR AVIEHNLLSA
210 220 230 240 250
SKLYNNITFE ELGALLEIPA AKAEKIASQM ITEGRMNGFI DQIDGIVHFE
260 270
TREALPTWDK QIQSLCFQVN NLLEK
Length:275
Mass (Da):31,433
Last modified:July 13, 2010 - v1
Checksum:iE6C30B9DBA2AAA34
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BT78CSN4_HUMAN
COP9 signalosome complex subunit 4
COPS4 CSN4
406Annotation score:
D6RFN0D6RFN0_HUMAN
COP9 signalosome complex subunit 4
COPS4
438Annotation score:
D6RAX7D6RAX7_HUMAN
COP9 constitutive photomorphogenic-...
COPS4
420Annotation score:
D6REK7D6REK7_HUMAN
COP9 signalosome complex subunit 4
COPS4
51Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei275Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021105 Genomic DNA No translation available.
AC073840 Genomic DNA No translation available.
AC108473 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000509317; ENSP00000425486; ENSG00000138663
UCSCiuc062xve.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021105 Genomic DNA No translation available.
AC073840 Genomic DNA No translation available.
AC108473 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliD6RD63
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiD6RD63
PeptideAtlasiD6RD63
PRIDEiD6RD63

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000509317; ENSP00000425486; ENSG00000138663
UCSCiuc062xve.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000138663.8
HGNCiHGNC:16702 COPS4
OpenTargetsiENSG00000138663
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1497 Eukaryota
ENOG410XPDE LUCA
GeneTreeiENSGT00730000111161
HOGENOMiHOG000158382

Miscellaneous databases

ChiTaRSiCOPS4 human

Gene expression databases

BgeeiENSG00000138663 Expressed in 233 organ(s), highest expression level in biceps brachii
ExpressionAtlasiD6RD63 baseline and differential

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR037754 CSN4
IPR000717 PCI_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10855:SF2 PTHR10855:SF2, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD6RD63_HUMAN
AccessioniPrimary (citable) accession number: D6RD63
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: September 12, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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