UniProtKB - D6RCB6 (D6RCB6_HUMAN)
Protein
Bifunctional lysine-specific demethylase and histidyl-hydroxylase
Gene
RIOX2
Organism
Homo sapiens (Human)
Status
Functioni
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.UniRule annotation
Cofactori
Fe2+UniRule annotationNote: Binds 1 Fe2+ ion per subunit.UniRule annotation
GO - Molecular functioni
- 2-oxoglutarate-dependent dioxygenase activity Source: UniProtKB-UniRule
- iron ion binding Source: UniProtKB-UniRule
Keywordsi
Molecular function | DioxygenaseUniRule annotation, Oxidoreductase |
Biological process | Transcription, Transcription regulationUniRule annotation |
Ligand | IronUniRule annotation, Metal-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Bifunctional lysine-specific demethylase and histidyl-hydroxylaseUniRule annotation (EC:1.14.11.-UniRule annotation) |
Gene namesi | Name:RIOX2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170854.17 |
HGNCi | HGNC:19441, RIOX2 |
Subcellular locationi
Keywords - Cellular componenti
NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000170854, Expressed in thyroid gland and 244 other tissues |
ExpressionAtlasi | D6RCB6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 111 | JmjCInterPro annotationAdd BLAST | 60 |
Sequence similaritiesi
Belongs to the ROX family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00390000000083 |
HOGENOMi | CLU_160400_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR003347, JmjC_dom IPR039994, JmjC_protein |
PANTHERi | PTHR13096, PTHR13096, 1 hit |
Pfami | View protein in Pfam PF08007, Cupin_4, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
D6RCB6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKKAKPTGS GKEEGPAPCK QMKLEAAGGP SALNFDSPSS LFESLISPIK
60 70 80 90 100
TETFFKEFWE QKPLLIQRDD PALATYYGSL FKLTDLKSLC SRGMYYGRDV
110
NVCRCVNGKK KV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8IUF8 | RIOX2_HUMAN | Ribosomal oxygenase 2 | RIOX2 MDIG, MINA, MINA53, NO52 | 465 | Annotation score: | ||
H0Y9L8 | H0Y9L8_HUMAN | Bifunctional lysine-specific demeth... | RIOX2 | 108 | Annotation score: | ||
H0Y8K4 | H0Y8K4_HUMAN | Ribosomal oxygenase 2 | RIOX2 | 27 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 112 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC026100 Genomic DNA No translation available. AC110491 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000506099; ENSP00000423816; ENSG00000170854 |
UCSCi | uc062lut.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC026100 Genomic DNA No translation available. AC110491 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | D6RCB6 |
PeptideAtlasi | D6RCB6 |
ProteomicsDBi | 13877 |
Protocols and materials databases
Antibodypediai | 2005, 370 antibodies |
Genome annotation databases
Ensembli | ENST00000506099; ENSP00000423816; ENSG00000170854 |
UCSCi | uc062lut.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170854.17 |
HGNCi | HGNC:19441, RIOX2 |
OpenTargetsi | ENSG00000170854 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000000083 |
HOGENOMi | CLU_160400_0_0_1 |
Gene expression databases
Bgeei | ENSG00000170854, Expressed in thyroid gland and 244 other tissues |
ExpressionAtlasi | D6RCB6, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR003347, JmjC_dom IPR039994, JmjC_protein |
PANTHERi | PTHR13096, PTHR13096, 1 hit |
Pfami | View protein in Pfam PF08007, Cupin_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D6RCB6_HUMAN | |
Accessioni | D6RCB6Primary (citable) accession number: D6RCB6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | October 7, 2020 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |