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Protein

Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23

Gene

USP17L23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17. It is present with an interindividual variation in copy number and between 20 to 103 copies can be found on chromosome 4 and chromosome 8.Curated
Product of a dubious gene prediction.Curated

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: GO_Central
  • thiol-dependent ubiquitin-specific protease activity Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000250913.2
HGNCiHGNC:44451 USP17L23
neXtProtiNX_D6RBM5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004210971 – 183Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23Add BLAST183

Proteomic databases

PaxDbiD6RBM5
PRIDEiD6RBM5
ProteomicsDBi13682

Expressioni

Gene expression databases

BgeeiENSG00000250913 Expressed in 26 organ(s), highest expression level in temporal lobe

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000424077

Structurei

3D structure databases

ProteinModelPortaliD6RBM5
SMRiD6RBM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 183USPAdd BLAST104

Sequence similaritiesi

Belongs to the peptidase C19 family. USP17 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
GeneTreeiENSGT00890000139343
HOGENOMiHOG000070037
InParanoidiD6RBM5
OMAiDAMEKAC
OrthoDBiEOG091G06D5
PhylomeDBiD6RBM5

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

D6RBM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD
60 70 80 90 100
LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY
110 120 130 140 150
TPPLANYMLS REHSQTCHRH KGCMLCTMQA HITRALHNPG HVIQPSQALA
160 170 180
AGFHRGKQED AHEFLMFTVD AMEKACLPGH KQV
Length:183
Mass (Da):20,302
Last modified:July 13, 2010 - v1
Checksum:iB29AAD40CE5A5DE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108519 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000506619; ENSP00000424077; ENSG00000250913
UCSCiuc062vda.1 human

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108519 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliD6RBM5
SMRiD6RBM5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000424077

Proteomic databases

PaxDbiD6RBM5
PRIDEiD6RBM5
ProteomicsDBi13682

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000506619; ENSP00000424077; ENSG00000250913
UCSCiuc062vda.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000250913.2
GeneCardsiUSP17L23
HGNCiHGNC:44451 USP17L23
neXtProtiNX_D6RBM5
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
GeneTreeiENSGT00890000139343
HOGENOMiHOG000070037
InParanoidiD6RBM5
OMAiDAMEKAC
OrthoDBiEOG091G06D5
PhylomeDBiD6RBM5

Gene expression databases

BgeeiENSG00000250913 Expressed in 26 organ(s), highest expression level in temporal lobe

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS50235 USP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiU17LN_HUMAN
AccessioniPrimary (citable) accession number: D6RBM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Peptidase families
    Classification of peptidase families and list of entries
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Main funding by: National Institutes of Health

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