UniProtKB - D6RAR4 (D6RAR4_HUMAN)
Protein
Submitted name:
Hepatocyte growth factor activator
Gene
HGFAC
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 454 | Charge relay systemUniRule annotation | 1 | |
Active sitei | 504 | Charge relay systemUniRule annotation | 1 | |
Active sitei | 605 | Charge relay systemUniRule annotation | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Serine proteaseUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Hepatocyte growth factor activatorImported |
Gene namesi | Name:HGFACImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000109758.8 |
HGNCi | HGNC:4894, HGFAC |
Subcellular locationi
Endoplasmic reticulum
- rough endoplasmic reticulum Source: Ensembl
Extracellular region or secreted
- extracellular space Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 35 | Sequence analysisAdd BLAST | 35 | |
ChainiPRO_5003087349 | 36 – 662 | Sequence analysisAdd BLAST | 627 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 169 ↔ 186 | PROSITE-ProRule annotation | ||
Disulfide bondi | 188 ↔ 197 | PROSITE-ProRule annotation | ||
Disulfide bondi | 250 ↔ 267 | PROSITE-ProRule annotation | ||
Disulfide bondi | 269 ↔ 278 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationProteomic databases
PeptideAtlasi | D6RAR4 |
PRIDEi | D6RAR4 |
ProteomicsDBi | 13403 |
Expressioni
Gene expression databases
Bgeei | ENSG00000109758, Expressed in right lobe of liver and 94 other tissues |
ExpressionAtlasi | D6RAR4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 103 – 150 | Fibronectin type-IIInterPro annotationAdd BLAST | 48 | |
Domaini | 160 – 198 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 200 – 240 | Fibronectin type-IInterPro annotationAdd BLAST | 41 | |
Domaini | 241 – 279 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 285 – 367 | KringleInterPro annotationAdd BLAST | 83 | |
Domaini | 415 – 653 | Peptidase S1InterPro annotationAdd BLAST | 239 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 64 – 102 | DisorderedSequence analysisAdd BLAST | 39 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, KringlePROSITE-ProRule annotationARBA annotation, SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000159778 |
HOGENOMi | CLU_006842_18_1_1 |
OMAi | GWGHMDE |
OrthoDBi | 1314811at2759 |
PhylomeDBi | D6RAR4 |
Family and domain databases
CDDi | cd00061, FN1, 1 hit cd00062, FN2, 1 hit cd00108, KR, 1 hit cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.10.10.10, 1 hit 2.40.10.10, 2 hits 2.40.20.10, 1 hit |
InterProi | View protein in InterPro IPR014394, Coagulation_fac_XII/HGFA IPR000742, EGF-like_dom IPR000083, Fibronectin_type1 IPR000562, FN_type2_dom IPR036943, FN_type2_sf IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00039, fn1, 1 hit PF00040, fn2, 1 hit PF00051, Kringle, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001146, Factor_XII_HGFA, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00058, FN1, 1 hit SM00059, FN2, 1 hit SM00130, KR, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 2 hits |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 2 hits PS01186, EGF_2, 1 hit PS50026, EGF_3, 2 hits PS01253, FN1_1, 1 hit PS51091, FN1_2, 1 hit PS00023, FN2_1, 1 hit PS51092, FN2_2, 1 hit PS00021, KRINGLE_1, 1 hit PS50070, KRINGLE_2, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
D6RAR4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRWAWVPSP WPPPGLGPFL LLLLLLLLLP RGFQPQPGGN RTESPEPNAT
60 70 80 90 100
ATPAIPTILV TSVTSETPAT SAPEAEGPQS GGLPPPPRAV PSSSSPQAQA
110 120 130 140 150
LTEDGRPCRF PFRYGGRMLH ACTSEGSAHR KWCATTHNYD RDRAWGYCVE
160 170 180 190 200
ATPPPGGPAA LDPCASGPCL NGGSCSNTQD PQSYHCSCPR AFTGKDCGTE
210 220 230 240 250
KCFDETRYEY LEGGDRWARV RQGHVEQCEC FGGRTWCEGT RHTACLSSPC
260 270 280 290 300
LNGGTCHLIV ATGTTVCACP PGFAGRLCNI EPDERCFLGN GTGYRGVAST
310 320 330 340 350
SASGLSCLAW NSDLLYQELH VDSVGAAALL GLGPHAYCRN PDNDERPWCY
360 370 380 390 400
VVKDSALSWE YCRLEACDLE TEGRESLTRV QLSPDLLATL PEPASPGRQA
410 420 430 440 450
CGRRHKKRTF LRPRIIGGSS SLPGSHPWLA AIYIGDSFCA GSLVHTCWVV
460 470 480 490 500
SAAHCFSHSP PRDSVSVVLG QHFFNRTTDV TQTFGIEKYI PYTLYSVFNP
510 520 530 540 550
SDHDLVLIRL KKKGDRCATR SQFVQPICLP EPGSTFPAGH KCQIAGWGHL
560 570 580 590 600
DENVSGYSSS LREALVPLVA DHKCSSPEVY GADISPNMLC AGYFDCKSDA
610 620 630 640 650
CQGDSGGPLA CEKNGVAYLY GIISWGDGCG RLHKPGVYTR VANYVDWIND
660
RIRPPRRLVA PS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ04756 | HGFA_HUMAN | Hepatocyte growth factor activator | HGFAC | 655 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590235 Genomic DNA No translation available. |
RefSeqi | NP_001284368.1, NM_001297439.1 |
Genome annotation databases
Ensembli | ENST00000511533; ENSP00000421801; ENSG00000109758 |
GeneIDi | 3083 |
UCSCi | uc010icw.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590235 Genomic DNA No translation available. |
RefSeqi | NP_001284368.1, NM_001297439.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | D6RAR4 |
PRIDEi | D6RAR4 |
ProteomicsDBi | 13403 |
Protocols and materials databases
Antibodypediai | 3925, 176 antibodies |
Genome annotation databases
Ensembli | ENST00000511533; ENSP00000421801; ENSG00000109758 |
GeneIDi | 3083 |
UCSCi | uc010icw.4, human |
Organism-specific databases
CTDi | 3083 |
EuPathDBi | HostDB:ENSG00000109758.8 |
HGNCi | HGNC:4894, HGFAC |
OpenTargetsi | ENSG00000109758 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159778 |
HOGENOMi | CLU_006842_18_1_1 |
OMAi | GWGHMDE |
OrthoDBi | 1314811at2759 |
PhylomeDBi | D6RAR4 |
Miscellaneous databases
BioGRID-ORCSi | 3083, 2 hits in 843 CRISPR screens |
ChiTaRSi | HGFAC, human |
GenomeRNAii | 3083 |
Gene expression databases
Bgeei | ENSG00000109758, Expressed in right lobe of liver and 94 other tissues |
ExpressionAtlasi | D6RAR4, baseline and differential |
Family and domain databases
CDDi | cd00061, FN1, 1 hit cd00062, FN2, 1 hit cd00108, KR, 1 hit cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.10.10.10, 1 hit 2.40.10.10, 2 hits 2.40.20.10, 1 hit |
InterProi | View protein in InterPro IPR014394, Coagulation_fac_XII/HGFA IPR000742, EGF-like_dom IPR000083, Fibronectin_type1 IPR000562, FN_type2_dom IPR036943, FN_type2_sf IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00039, fn1, 1 hit PF00040, fn2, 1 hit PF00051, Kringle, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001146, Factor_XII_HGFA, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00058, FN1, 1 hit SM00059, FN2, 1 hit SM00130, KR, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 2 hits |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 2 hits PS01186, EGF_2, 1 hit PS50026, EGF_3, 2 hits PS01253, FN1_1, 1 hit PS51091, FN1_2, 1 hit PS00023, FN2_1, 1 hit PS51092, FN2_2, 1 hit PS00021, KRINGLE_1, 1 hit PS50070, KRINGLE_2, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D6RAR4_HUMAN | |
Accessioni | D6RAR4Primary (citable) accession number: D6RAR4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | December 2, 2020 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |