UniProtKB - D6R9K8 (D6R9K8_HUMAN)
Protein
Submitted name:
All-trans-retinol dehydrogenase [NAD(+)] ADH4
Gene
ADH4
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Zn2+ARBA annotation
GO - Molecular functioni
- alcohol dehydrogenase activity, zinc-dependent Source: InterPro
- ethanol binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- ethanol oxidation Source: InterPro
Keywordsi
Molecular function | OxidoreductaseARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: All-trans-retinol dehydrogenase [NAD(+)] ADH4Imported |
Gene namesi | Name:ADH4Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198099.8 |
HGNCi | HGNC:252, ADH4 |
Subcellular locationi
PTM / Processingi
Proteomic databases
MaxQBi | D6R9K8 |
PeptideAtlasi | D6R9K8 |
PRIDEi | D6R9K8 |
ProteomicsDBi | 13040 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198099, Expressed in liver and 196 other tissues |
ExpressionAtlasi | D6R9K8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 184 | ADH_NInterPro annotationAdd BLAST | 131 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000162645 |
Family and domain databases
InterProi | View protein in InterPro IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR028632, Zinc_ADH_II |
PANTHERi | PTHR43880:SF14, PTHR43880:SF14, 1 hit |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
D6R9K8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVRGPHFEL QRCKTHLFSS NYLTQVIKCK AAIAWEAGKP LCIEEVEVAP
60 70 80 90 100
PKAHEVRIQI IATSLCHTDA TVIDSKFEGL AFPVIVGHEA AGIVESIGPG
110 120 130 140 150
VTNVKPGDKV IPLYAPLCRK CKFCLSPLTN LCGKISNLKS PASDQQLMED
160 170 180 190 200
KTSRFTCKGK PVYHFFGTST FSQYTVVSDI NLAKIDDDAN LERVCLLGCG
210 220 230 240 250
FSTGYGAAIN NAKVTPGSTC AVFGLGGVGL SAVMGCKAAG ASRIIGIDIN
SEKFVKA
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP08319 | ADH4_HUMAN | All-trans-retinol dehydrogenase [NA... | ADH4 | 380 | Annotation score: | ||
A0A0D9SFB5 | A0A0D9SFB5_HUMAN | All-trans-retinol dehydrogenase [NA... | ADH4 | 391 | Annotation score: | ||
D6RIB1 | D6RIB1_HUMAN | All-trans-retinol dehydrogenase [NA... | ADH4 | 206 | Annotation score: | ||
H0Y9N0 | H0Y9N0_HUMAN | All-trans-retinol dehydrogenase [NA... | ADH4 | 115 | Annotation score: | ||
D6RF43 | D6RF43_HUMAN | All-trans-retinol dehydrogenase [NA... | ADH4 | 36 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 257 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC019131 Genomic DNA No translation available. AEKP01108208 Genomic DNA No translation available. AP002026 Genomic DNA No translation available. KF510251 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000512499; ENSP00000423571; ENSG00000198099 |
UCSCi | uc062yki.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC019131 Genomic DNA No translation available. AEKP01108208 Genomic DNA No translation available. AP002026 Genomic DNA No translation available. KF510251 Genomic DNA No translation available. |
3D structure databases
SMRi | D6R9K8 |
ModBasei | Search... |
Proteomic databases
MaxQBi | D6R9K8 |
PeptideAtlasi | D6R9K8 |
PRIDEi | D6R9K8 |
ProteomicsDBi | 13040 |
Protocols and materials databases
Antibodypediai | 14813, 265 antibodies |
Genome annotation databases
Ensembli | ENST00000512499; ENSP00000423571; ENSG00000198099 |
UCSCi | uc062yki.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198099.8 |
HGNCi | HGNC:252, ADH4 |
OpenTargetsi | ENSG00000198099 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000162645 |
Miscellaneous databases
ChiTaRSi | ADH4, human |
Gene expression databases
Bgeei | ENSG00000198099, Expressed in liver and 196 other tissues |
ExpressionAtlasi | D6R9K8, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR028632, Zinc_ADH_II |
PANTHERi | PTHR43880:SF14, PTHR43880:SF14, 1 hit |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D6R9K8_HUMAN | |
Accessioni | D6R9K8Primary (citable) accession number: D6R9K8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | October 7, 2020 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |