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Protein
Submitted name:

Pituitary homeobox 1

Gene

PITX1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Pituitary homeobox 1Imported
Gene namesi
Name:PITX1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000069011.15
HGNCiHGNC:9004 PITX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000069011

PTM / Processingi

Proteomic databases

MaxQBiD6R955
PeptideAtlasiD6R955
PRIDEiD6R955

Expressioni

Gene expression databases

BgeeiENSG00000069011 Expressed in 118 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiD6R955 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliD6R955
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 114HomeoboxInterPro annotationAdd BLAST28

Keywords - Domaini

HomeoboxPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0486 Eukaryota
ENOG410ZZ6J LUCA
GeneTreeiENSGT00930000150861

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

D6R955-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAFKGGMSL ERLPEGLRPP PPPPHDMGPA FHLARPADPR EPLENSASES
60 70 80 90 100
SDTELPEKER GGEPKGPEDS GAGGTGCGGA DDPAKKKKQR RQRTHFTSQQ
110
LQELEATFQR NRYP
Length:114
Mass (Da):12,445
Last modified:July 13, 2010 - v1
Checksum:i2D3A560B1F2D6831
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P78337PITX1_HUMAN
Pituitary homeobox 1
PITX1 BFT, PTX1
314Annotation score:
H0YJC8H0YJC8_HUMAN
Pituitary homeobox 1
PITX1
208Annotation score:
D6R9U1D6R9U1_HUMAN
Pituitary homeobox 1
PITX1
130Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei114Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008406 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000502676; ENSP00000423624; ENSG00000069011
UCSCiuc063hdo.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008406 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliD6R955
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiD6R955
PeptideAtlasiD6R955
PRIDEiD6R955

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502676; ENSP00000423624; ENSG00000069011
UCSCiuc063hdo.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000069011.15
HGNCiHGNC:9004 PITX1
OpenTargetsiENSG00000069011
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0486 Eukaryota
ENOG410ZZ6J LUCA
GeneTreeiENSGT00930000150861

Miscellaneous databases

ChiTaRSiPITX1 human

Gene expression databases

BgeeiENSG00000069011 Expressed in 118 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiD6R955 baseline and differential

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD6R955_HUMAN
AccessioniPrimary (citable) accession number: D6R955
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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