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Entry version 39 (02 Jun 2021)
Sequence version 2 (10 May 2017)
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Protein

Hydantoin permease

Gene

hyuP

Organism
Microbacterium liquefaciens (Aureobacterium liquefaciens)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nucleobase-proton symporter that mediates the sodium-dependent binding and uptake of 5-aryl-substituted hydantoin compounds (PubMed:16621827, PubMed:24952894).

5-indolyl methyl hydantoin and 5-benzyl hydantoin are the preferred substrates, with selectivity for a hydrophobic substituent in position 5 of hydantoin and for the L isomer over the D isomer (PubMed:16621827, PubMed:24952894).

1 Publication2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by dinitrophenol, 5-(2-naphthylmethyl)-D-hydantoin (D-NMH), 5-(2-naphthylmethyl)-L-hydantoin (L-NMH), 5-bromovinylhydantoin (BVH) and 5-indolylmethyl-L-hydantoin (L-IMH) (PubMed:16621827, PubMed:24952894). The affinity of benzyl-hydantoin is increased over 10-fold in the presence of 15 mM of sodium (PubMed:18927357).3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 6.6.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi38Sodium; via carbonyl oxygenCombined sources2 Publications1
Metal bindingi41Sodium; via carbonyl oxygenCombined sources2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei121SubstrateCombined sources1 Publication1
Binding sitei219Substrate; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi309Sodium; via carbonyl oxygenCombined sources2 Publications1
Metal bindingi312SodiumCombined sources2 Publications1
Metal bindingi313SodiumCombined sources2 Publications1
Binding sitei318SubstrateCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandMetal-binding, Sodium

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.39.3.6, the nucleobase:cation symporter-1 (ncs1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hydantoin permease1 Publication
Short name:
MHP1 Publication
Alternative name(s):
Hydantoin transport protein1 Publication
NCS1 benzyl-hydantoin transporter1 Publication
Nucleobase cation symporter 11 Publication
Short name:
NCS11 Publication
Sodium-coupled secondary active transport protein1 Publication
Sodium-hydantoin transporter Mhp11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hyuP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMicrobacterium liquefaciens (Aureobacterium liquefaciens)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri33918 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeMicrobacterium

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei167 – 187Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei207 – 227Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei258 – 278Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei299 – 321Helical; Name=8Sequence analysisAdd BLAST23
Transmembranei339 – 359Helical; Name=9Sequence analysisAdd BLAST21
Transmembranei362 – 382Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei405 – 424Helical; Name=11Sequence analysisAdd BLAST20
Transmembranei428 – 445Helical; Name=12Sequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi42Q → F: Strong decrease in uptake and binding efficiency. 1 Publication1
Mutagenesisi42Q → N: Modest decrease in uptake and binding efficiency. 1 Publication1
Mutagenesisi117W → A: Reduces dramatically the uptake efficiency. 1 Publication1
Mutagenesisi117W → F: Reduces moderately the uptake efficiency. 1 Publication1
Mutagenesisi121Q → N: Partial decrease in efficiency of both binding and uptake. 1 Publication1
Mutagenesisi219G → I or S: Reduces both binding and uptake efficiency. 1 Publication1
Mutagenesisi220W → A or F: Little effect on uptake efficiency. 1 Publication1
Mutagenesisi318N → A: Significant loss of uptake activity and a substantial reduction in binding efficiency. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004399231 – 489Hydantoin permeaseAdd BLAST489

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1489
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D6R8X8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
D6R8X8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni468 – 489DisorderedSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4160.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001248, Pur-cyt_permease
IPR038271, Pur-cyt_permease_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02133, Transp_cyt_pur, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D6R8X8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSTPIEEAR SLLNPSNAPT RYAERSVGPF SLAAIWFAMA IQVAIFIAAG
60 70 80 90 100
QMTSSFQVWQ VIVAIAAGCT IAVILLFFTQ SAAIRWGINF TVAARMPFGI
110 120 130 140 150
RGSLIPITLK ALLSLFWFGF QTWLGALALD EITRLLTGFT NLPLWIVIFG
160 170 180 190 200
AIQVVTTFYG ITFIRWMNVF ASPVLLAMGV YMVYLMLDGA DVSLGEVMSM
210 220 230 240 250
GGENPGMPFS TAIMIFVGGW IAVVVSIHDI VKECKVDPNA SREGQTKADA
260 270 280 290 300
RYATAQWLGM VPASIIFGFI GAASMVLVGE WNPVIAITEV VGGVSIPMAI
310 320 330 340 350
LFQVFVLLAT WSTNPAANLL SPAYTLCSTF PRVFTFKTGV IVSAVVGLLM
360 370 380 390 400
MPWQFAGVLN TFLNLLASAL GPLAGIMISD YFLVRRRRIS LHDLYRTKGI
410 420 430 440 450
YTYWRGVNWV ALAVYAVALA VSFLTPDLMF VTGLIAALLL HIPAMRWVAK
460 470 480
TFPLFSEAES RNEDYLRPIG PVAPADESAT ANTKEQNQR
Length:489
Mass (Da):53,332
Last modified:May 10, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98796385DB8DB45A
GO

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JLNX-ray2.85A1-488[»]
2X79X-ray3.80A1-488[»]
4D1AX-ray3.40A1-487[»]
4D1BX-ray3.80A1-487[»]
4D1CX-ray3.70A1-487[»]
4D1DX-ray3.70A1-487[»]
SMRiD6R8X8
ModBaseiSearch...
PDBe-KBiSearch...

Protein family/group databases

TCDBi2.A.39.3.6, the nucleobase:cation symporter-1 (ncs1) family

Miscellaneous databases

EvolutionaryTraceiD6R8X8

Family and domain databases

Gene3Di1.10.4160.10, 1 hit
InterProiView protein in InterPro
IPR001248, Pur-cyt_permease
IPR038271, Pur-cyt_permease_sf
PfamiView protein in Pfam
PF02133, Transp_cyt_pur, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHYUP_MICLQ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D6R8X8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: May 10, 2017
Last modified: June 2, 2021
This is version 39 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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