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Protein

Conotoxin Cl6.8

Gene
N/A
Organism
Californiconus californicus (California cone) (Conus californicus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Cl6.8
OrganismiCaliforniconus californicus (California cone) (Conus californicus)
Taxonomic identifieri1736779 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeCaliforniconus

Organism-specific databases

ConoServeri4042 Cl6.8 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000041498723 – 39By similarityAdd BLAST17
PeptideiPRO_000041498842 – 66Conotoxin Cl6.8Add BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 58By similarity
Disulfide bondi50 ↔ 62By similarity
Disulfide bondi57 ↔ 66By similarity
Modified residuei66Cysteine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiD6C4L6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin O1 superfamily.Curated

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D6C4L6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVTAVLMVA VLVLTACQLT TANTTDYVRR ILARKSTMSK RYCSDSGGWC
60
GLDPELCCNS SCFVLCG
Length:67
Mass (Da):7,257
Last modified:July 13, 2010 - v1
Checksum:i96D0829F8CA87A4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ959158 Genomic DNA Translation: ADB93128.1

Similar proteinsi

Entry informationi

Entry nameiCM68_CONCL
AccessioniPrimary (citable) accession number: D6C4L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: July 13, 2010
Last modified: September 12, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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