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Protein

Conotoxin Cl6.15

Gene
N/A
Organism
Californiconus californicus (California cone) (Conus californicus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Cl6.15
OrganismiCaliforniconus californicus (California cone) (Conus californicus)
Taxonomic identifieri1736779 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeCaliforniconus

Organism-specific databases

ConoServeri4031 Cl6.15 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000041500320 – 37By similarityAdd BLAST18
PeptideiPRO_000041500440 – 77Conotoxin Cl6.15Add BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 61By similarity
Disulfide bondi55 ↔ 66By similarity
Disulfide bondi60 ↔ 75By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiD6C4K5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is VI/VII (C-C-CC-C-C).
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Keywords - Domaini

Knottin, Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D6C4K5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLSVKFLLF LMILPLIAGE DMSDNDAPKS VDVQRNVKRQ GQSQFGEQCT
60 70
GHLDCFGDLC CFDGYCIMTS WIWPCNW
Length:77
Mass (Da):8,796
Last modified:July 13, 2010 - v1
Checksum:i009186C208FB5102
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ959147 Genomic DNA Translation: ADB93117.1

Entry informationi

Entry nameiCI16F_CONCL
AccessioniPrimary (citable) accession number: D6C4K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: July 13, 2010
Last modified: September 12, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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