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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Caulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei601For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

BioCyciCSEG509190:G1GKR-119-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:Cseg_0114Imported
OrganismiCaulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis)Imported
Taxonomic identifieri509190 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000002629 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi509190.Cseg_0114

Structurei

3D structure databases

ProteinModelPortaliD5VDU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 217Glutamine amidotransferase type-2InterPro annotationAdd BLAST216
Domaini280 – 421SISInterPro annotationAdd BLAST142
Domaini454 – 596SISInterPro annotationAdd BLAST143

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D5VDU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIIGIVGK QPVADRLIES LKRLEYRGYD SAGIAGVVDG KVQRRRAQGK
60 70 80 90 100
IKALEAVLAD EPLNAATGIG HTRWATHGAP NVKNAHPHAA GRVTLVHNGI
110 120 130 140 150
IENFAELKAE LIAAGRVFES DTDTEVIAQL IDAELATGLA PLEAFKATLD
160 170 180 190 200
RLTGAYALAV LIEGEENLIL GARRGSPLVV GEGQGEMFLG SDALAVGPFT
210 220 230 240 250
NRVIYLDEGD YVALDHDSHR IFDVSGTPVT RPVRVVPTSA VMLEKGNYRH
260 270 280 290 300
FMEKEIHDQP EGCQRTIAAY VDTLTSRAAI PGDIDFAKLE RIQVVACGTS
310 320 330 340 350
YIAGVVGKYL IEQLADLPVD VEIASEFRYR QPALRPGSLV IAMSQSGETA
360 370 380 390 400
DTLAALRYCK AKGMKSAVVV NAQESTMARE VDVVWPIHCG PEIGVASTKA
410 420 430 440 450
FTAQVSVMIA LAIAAAKARG TIDAAEERRL VKVLLEAPRL IAEAIGLEDA
460 470 480 490 500
IKEIAADVAK ARDVLYLGRG PMSALALEGA LKLKEISYIH AEGYAAGELK
510 520 530 540 550
HGPIALVDDQ TPIVILAPYD SYFEKSASNM SEVMARGGQV IFITDTEGVK
560 570 580 590 600
HAPAGAKVVV TAPASDPLVS TLVMSAPIQL LAYHVAVVKG ADVDQPRNLA

KSVTVE
Length:606
Mass (Da):64,449
Last modified:July 13, 2010 - v1
Checksum:i16C723359DBED937
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002008 Genomic DNA Translation: ADG08641.1
RefSeqiWP_013077316.1, NC_014100.1

Genome annotation databases

EnsemblBacteriaiADG08641; ADG08641; Cseg_0114
GeneIDi35837542
KEGGicse:Cseg_0114

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002008 Genomic DNA Translation: ADG08641.1
RefSeqiWP_013077316.1, NC_014100.1

3D structure databases

ProteinModelPortaliD5VDU1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi509190.Cseg_0114

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG08641; ADG08641; Cseg_0114
GeneIDi35837542
KEGGicse:Cseg_0114

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Enzyme and pathway databases

BioCyciCSEG509190:G1GKR-119-MONOMER

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiD5VDU1_CAUST
AccessioniPrimary (citable) accession number: D5VDU1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: April 25, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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