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Protein

Argininosuccinate synthase

Gene

argG

Organism
Brachyspira murdochii (strain ATCC 51284 / DSM 12563 / 56-150) (Serpulina murdochii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei86CitrullineUniRule annotation1
Binding sitei91CitrullineUniRule annotation1
Binding sitei116ATP; via amide nitrogenUniRule annotation1
Binding sitei118AspartateUniRule annotation1
Binding sitei122AspartateUniRule annotation1
Binding sitei122CitrullineUniRule annotation1
Binding sitei123AspartateUniRule annotation1
Binding sitei126CitrullineUniRule annotation1
Binding sitei175CitrullineUniRule annotation1
Binding sitei184CitrullineUniRule annotation1
Binding sitei261CitrullineUniRule annotation1
Binding sitei273CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 16ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBMUR526224:G1GLI-1060-MONOMER
UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotationSAAS annotation (EC:6.3.4.5UniRule annotationSAAS annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Bmur_1049Imported
OrganismiBrachyspira murdochii (strain ATCC 51284 / DSM 12563 / 56-150) (Serpulina murdochii)Imported
Taxonomic identifieri526224 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesBrachyspiralesBrachyspiraceaeBrachyspira
Proteomesi
  • UP000001915 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi526224.Bmur_1049

Structurei

3D structure databases

ProteinModelPortaliD5U8X2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

D5U8X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKLVLAYS GGLDTTVIIP WLKENYDYDI IAACVDVGQG TETDGLEEKA
60 70 80 90 100
IKTGASKYYL VKCEDEFVTD YIYPILKADA VYEDKYLLGT SAARPLIAKK
110 120 130 140 150
LVEIALKEGA SAIAHGATGK GNDQVRFELT VKALAPNLEI IAPWRIWDIS
160 170 180 190 200
SREDEIKYLE ERNIPVPMKK DDSYSRDKNL WHLSHEGLEL EDPANMPNYE
210 220 230 240 250
KLLKLSNTIE NAPNEAQFVE LEFEKGIPVK ADGKEFAPAD LVKYLNEIGG
260 270 280 290 300
KHAVGIVDLV ENRVVGIKSR GVYETPGGTI LYAAHRELEH LCLDRETLSF
310 320 330 340 350
KAIVANKLTD LVYSGRWFTP LREALSAFVD KTQETVTGKV KLKLYKGNII
360 370 380 390 400
PAGASSPYSL YNQSLASFTT GELYNHKDAE GFITLYGLPL KVNALMKEQN

KKTGLNN
Length:407
Mass (Da):45,329
Last modified:July 13, 2010 - v1
Checksum:iB0CC2F95C29A46B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001959 Genomic DNA Translation: ADG71145.1
RefSeqiWP_013113571.1, NC_014150.1

Genome annotation databases

EnsemblBacteriaiADG71145; ADG71145; Bmur_1049
KEGGibrm:Bmur_1049

Similar proteinsi

Entry informationi

Entry nameiD5U8X2_BRAM5
AccessioniPrimary (citable) accession number: D5U8X2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: June 20, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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