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Protein
Submitted name:

Calcium-activated potassium channel subunit alpha-1

Gene

KCNMA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Calcium-activated potassium channel subunit alpha-1Imported
Submitted name:
Large-conductance calcium-activated potassium channel alpha subunitImported
Gene namesi
Name:KCNMA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:6284 KCNMA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei127 – 144HelicalSequence analysisAdd BLAST18
Transmembranei165 – 181HelicalSequence analysisAdd BLAST17
Transmembranei246 – 267HelicalSequence analysisAdd BLAST22
Transmembranei282 – 301HelicalSequence analysisAdd BLAST20
Transmembranei313 – 331HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156113

PTM / Processingi

Proteomic databases

PeptideAtlasiD5MRH1
PRIDEiD5MRH1

Expressioni

Gene expression databases

ExpressionAtlasiD5MRH1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliD5MRH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 337Ion_transInterPro annotationAdd BLAST209

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000063026
HOGENOMiHOG000019856

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR024939 Ca-act_K_channel_Slo-1
IPR005821 Ion_trans_dom
IPR003929 K_chnl_BK_asu
IPR036291 NAD(P)-bd_dom_sf
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10027:SF28 PTHR10027:SF28, 2 hits
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
SUPFAMiSSF51735 SSF51735, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 69 potential isoforms that are computationally mapped.Show allAlign All

D5MRH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANGGGGGGG SSGGGGGGGG SSLRMSSNIH ANHLSLDASS SSSSSSSSSS
60 70 80 90 100
SSSSSSSSSS VHEPKMDALI IPVTMEVPCD SRGQRMWWAF LASSMVTFFG
110 120 130 140 150
GLFIILLWRT LKYLWTVCCH CGGKTKVVLV FALSIGALVI YFIDSSNPIE
160 170 180 190 200
SCQNFYKDFT LQIDMAFNVF FLLYFGLRFI AANDKLWFWL EVNSVVDFFT
210 220 230 240 250
VPPVFVSVYL NRSWLGLRFL RALRLIQFSE ILQFLNILKT SNSIKLVNLL
260 270 280 290 300
SIFISTWLTA AGFIHLVENS GDPWENFQNN QALTYWECVY LLMVTMSTVG
310 320 330 340 350
YGDVYAKTTL GRLFMVFFIL GGLAMFASYV PEIIELIGNR KKYGGSYSAV
360 370 380 390 400
SGRKHIVVCG HITLESVSNF LKDFLHKDRD DVNVEIVFLH NISPNLELEA
410 420 430 440 450
LFKRHFTQVE FYQGSVLNPH DLARVKIESA DACLILANKY CADPDAEDAS
460 470 480 490 500
NIMRVISIKN YHPKIRIITQ MLQYHNKAHL LNIPSWNWKE GDDAICLAEL
510 520 530 540 550
KLGFIAQSCL AQGLSTMLAN LFSMRSFIKI EEDTWQKYYL EGVSNEMYTE
560 570 580 590 600
YLSSAFVGLS FPTVCELCFV KLKLLMIAIE YKSANRESRS RKRILINPGN
610 620 630 640 650
HLKIQEGTLG FFIASDAKEV KRAFFYCKAC HDDITDPKRI KKCGCKRLED
660 670 680 690 700
EQPSTLSPKK KQRNGGMRNS PNTSPKLMRH DPLLIPGNDQ IDNMDSNVKK
710 720 730 740 750
YDSTGMFHWC APKEIEKVIL TRSEAAMTVL SGHVVVCIFG DVSSALIGLR
760 770 780 790 800
NLVMPLRASN FHYHELKHIV FVGSIEYLKR EWETLHNFPK VSILPGTPLS
810 820 830 840 850
RADLRAVNIN LCDMCVILSA NQNNIDDTSL QDKECILASL NIKSMQFDDS
860 870 880 890 900
IGVLQANSQG FTPPGMDRSS PDNSPVHGML RQPSITTGVN IPIITELVND
910 920 930 940 950
TNVQFLDQDD DDDPDTELYL TQPFACGTAF AVSVLDSLMS ATYFNDNILT
960 970 980 990 1000
LIRTLVTGGA TPELEALIAE ENALRGGYST PQTLANRDRC RVAQLALLDG
1010 1020 1030 1040 1050
PFADLGDGGC YGDLFCKALK TYNMLCFGIY RLRDAHLSTP SQCTKRYVIT
1060 1070 1080 1090 1100
NPPYEFELVP TDLIFCLMQF DHNAGQSRAS LSHSSHSSQS SSKKSSSVHS
1110 1120
IPSTANRQNR PKSRESRDKQ NRKEMVYR
Length:1,128
Mass (Da):125,857
Last modified:July 13, 2010 - v1
Checksum:i5E1A8BBCD3C4E294
GO

Computationally mapped potential isoform sequencesi

There are 69 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q12791KCMA1_HUMAN
Calcium-activated potassium channel...
KCNMA1 KCNMA, SLO
1,236Annotation score:
A0A1W2PRT6A0A1W2PRT6_HUMAN
Calcium-activated potassium channel...
KCNMA1
383Annotation score:
Q5SVJ8Q5SVJ8_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,288Annotation score:
Q5SVK0Q5SVK0_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,195Annotation score:
Q5SVK5Q5SVK5_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,232Annotation score:
H0Y379H0Y379_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,192Annotation score:
Q5SVJ9Q5SVJ9_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,235Annotation score:
B7ZMF5B7ZMF5_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,208Annotation score:
J3KQ16J3KQ16_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,040Annotation score:
A0A0A0MSE6A0A0A0MSE6_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,142Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011439 Genomic DNA No translation available.
AC021032 Genomic DNA No translation available.
AC067745 Genomic DNA No translation available.
AL157833 Genomic DNA No translation available.
AL607069 Genomic DNA No translation available.
AL627447 Genomic DNA No translation available.
AL731556 Genomic DNA No translation available.
AL731560 Genomic DNA No translation available.
AL731575 Genomic DNA No translation available.
AB524033 mRNA Translation: BAJ07308.1
RefSeqiNP_001258447.1, NM_001271518.1
UniGeneiHs.144795
Hs.658064

Genome annotation databases

EnsembliENST00000640807; ENSP00000491555; ENSG00000156113
GeneIDi3778

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011439 Genomic DNA No translation available.
AC021032 Genomic DNA No translation available.
AC067745 Genomic DNA No translation available.
AL157833 Genomic DNA No translation available.
AL607069 Genomic DNA No translation available.
AL627447 Genomic DNA No translation available.
AL731556 Genomic DNA No translation available.
AL731560 Genomic DNA No translation available.
AL731575 Genomic DNA No translation available.
AB524033 mRNA Translation: BAJ07308.1
RefSeqiNP_001258447.1, NM_001271518.1
UniGeneiHs.144795
Hs.658064

3D structure databases

ProteinModelPortaliD5MRH1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiD5MRH1
PRIDEiD5MRH1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000640807; ENSP00000491555; ENSG00000156113
GeneIDi3778

Organism-specific databases

CTDi3778
HGNCiHGNC:6284 KCNMA1
OpenTargetsiENSG00000156113
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063026
HOGENOMiHOG000019856

Miscellaneous databases

ChiTaRSiKCNMA1 human
GenomeRNAii3778

Gene expression databases

ExpressionAtlasiD5MRH1 baseline and differential

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR024939 Ca-act_K_channel_Slo-1
IPR005821 Ion_trans_dom
IPR003929 K_chnl_BK_asu
IPR036291 NAD(P)-bd_dom_sf
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10027:SF28 PTHR10027:SF28, 2 hits
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
SUPFAMiSSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD5MRH1_HUMAN
AccessioniPrimary (citable) accession number: D5MRH1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: July 18, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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