Calcium-activated potassium channel subunit alpha-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• large conductance calcium-activated potassium channel activity Source: InterPro
• voltage-gated potassium channel activity Source: InterPro

GO - Biological processⁱ

• regulation of ion transmembrane transport Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 69 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MANGGGGGGG SSGGGGGGGG SSLRMSSNIH ANHLSLDASS SSSSSSSSSS 
        60         70         80         90        100
SSSSSSSSSS VHEPKMDALI IPVTMEVPCD SRGQRMWWAF LASSMVTFFG 
       110        120        130        140        150
GLFIILLWRT LKYLWTVCCH CGGKTKVVLV FALSIGALVI YFIDSSNPIE 
       160        170        180        190        200
SCQNFYKDFT LQIDMAFNVF FLLYFGLRFI AANDKLWFWL EVNSVVDFFT 
       210        220        230        240        250
VPPVFVSVYL NRSWLGLRFL RALRLIQFSE ILQFLNILKT SNSIKLVNLL 
       260        270        280        290        300
SIFISTWLTA AGFIHLVENS GDPWENFQNN QALTYWECVY LLMVTMSTVG 
       310        320        330        340        350
YGDVYAKTTL GRLFMVFFIL GGLAMFASYV PEIIELIGNR KKYGGSYSAV 
       360        370        380        390        400
SGRKHIVVCG HITLESVSNF LKDFLHKDRD DVNVEIVFLH NISPNLELEA 
       410        420        430        440        450
LFKRHFTQVE FYQGSVLNPH DLARVKIESA DACLILANKY CADPDAEDAS 
       460        470        480        490        500
NIMRVISIKN YHPKIRIITQ MLQYHNKAHL LNIPSWNWKE GDDAICLAEL 
       510        520        530        540        550
KLGFIAQSCL AQGLSTMLAN LFSMRSFIKI EEDTWQKYYL EGVSNEMYTE 
       560        570        580        590        600
YLSSAFVGLS FPTVCELCFV KLKLLMIAIE YKSANRESRS RKRILINPGN 
       610        620        630        640        650
HLKIQEGTLG FFIASDAKEV KRAFFYCKAC HDDITDPKRI KKCGCKRLED 
       660        670        680        690        700
EQPSTLSPKK KQRNGGMRNS PNTSPKLMRH DPLLIPGNDQ IDNMDSNVKK 
       710        720        730        740        750
YDSTGMFHWC APKEIEKVIL TRSEAAMTVL SGHVVVCIFG DVSSALIGLR 
       760        770        780        790        800
NLVMPLRASN FHYHELKHIV FVGSIEYLKR EWETLHNFPK VSILPGTPLS 
       810        820        830        840        850
RADLRAVNIN LCDMCVILSA NQNNIDDTSL QDKECILASL NIKSMQFDDS 
       860        870        880        890        900
IGVLQANSQG FTPPGMDRSS PDNSPVHGML RQPSITTGVN IPIITELVND 
       910        920        930        940        950
TNVQFLDQDD DDDPDTELYL TQPFACGTAF AVSVLDSLMS ATYFNDNILT 
       960        970        980        990       1000
LIRTLVTGGA TPELEALIAE ENALRGGYST PQTLANRDRC RVAQLALLDG 
      1010       1020       1030       1040       1050
PFADLGDGGC YGDLFCKALK TYNMLCFGIY RLRDAHLSTP SQCTKRYVIT 
      1060       1070       1080       1090       1100
NPPYEFELVP TDLIFCLMQF DHNAGQSRAS LSHSSHSSQS SSKKSSSVHS 
      1110       1120 
IPSTANRQNR PKSRESRDKQ NRKEMVYR                         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ