UniProtKB - D5MRH1 (D5MRH1_HUMAN)
Protein
BK channel
Gene
KCNMA1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- large conductance calcium-activated potassium channel activity Source: InterPro
Keywordsi
Molecular function | Ion channel, Potassium channelARBA annotation |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | CalciumARBA annotation, Potassium |
Names & Taxonomyi
Protein namesi | Recommended name: BK channelARBA annotationAlternative name(s): BKCA alphaARBA annotation Calcium-activated potassium channel subunit alpha-1ARBA annotation Calcium-activated potassium channel, subfamily M subunit alpha-1ARBA annotation K(VCA)alphaARBA annotation KCa1.1ARBA annotation Maxi K channelARBA annotation Slo-alphaARBA annotation Slo1ARBA annotation Slowpoke homologARBA annotation |
Gene namesi | Name:KCNMA1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6284, KCNMA1 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 127 – 144 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 165 – 181 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 246 – 267 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 282 – 301 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 313 – 331 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 129 – 337 | Ion_transInterPro annotationAdd BLAST | 209 | |
Domaini | 484 – 579 | BK_channel_aInterPro annotationAdd BLAST | 96 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 61 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 651 – 679 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 1078 – 1128 | DisorderedSequence analysisAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 61 | PolarSequence analysisAdd BLAST | 41 | |
Compositional biasi | 658 – 676 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1078 – 1109 | PolarSequence analysisAdd BLAST | 32 | |
Compositional biasi | 1110 – 1128 | PolyampholyteSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily. [View classification]ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000154935 |
OrthoDBi | 124461at2759 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR024939, Ca-act_K_channel_Slo-1 IPR005821, Ion_trans_dom IPR003929, K_chnl_BK_asu IPR036291, NAD(P)-bd_dom_sf IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR10027:SF28, PTHR10027:SF28, 1 hit |
Pfami | View protein in Pfam PF03493, BK_channel_a, 1 hit PF00520, Ion_trans, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 68 potential isoforms that are computationally mapped.Show allAlign All
D5MRH1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANGGGGGGG SSGGGGGGGG SSLRMSSNIH ANHLSLDASS SSSSSSSSSS
60 70 80 90 100
SSSSSSSSSS VHEPKMDALI IPVTMEVPCD SRGQRMWWAF LASSMVTFFG
110 120 130 140 150
GLFIILLWRT LKYLWTVCCH CGGKTKVVLV FALSIGALVI YFIDSSNPIE
160 170 180 190 200
SCQNFYKDFT LQIDMAFNVF FLLYFGLRFI AANDKLWFWL EVNSVVDFFT
210 220 230 240 250
VPPVFVSVYL NRSWLGLRFL RALRLIQFSE ILQFLNILKT SNSIKLVNLL
260 270 280 290 300
SIFISTWLTA AGFIHLVENS GDPWENFQNN QALTYWECVY LLMVTMSTVG
310 320 330 340 350
YGDVYAKTTL GRLFMVFFIL GGLAMFASYV PEIIELIGNR KKYGGSYSAV
360 370 380 390 400
SGRKHIVVCG HITLESVSNF LKDFLHKDRD DVNVEIVFLH NISPNLELEA
410 420 430 440 450
LFKRHFTQVE FYQGSVLNPH DLARVKIESA DACLILANKY CADPDAEDAS
460 470 480 490 500
NIMRVISIKN YHPKIRIITQ MLQYHNKAHL LNIPSWNWKE GDDAICLAEL
510 520 530 540 550
KLGFIAQSCL AQGLSTMLAN LFSMRSFIKI EEDTWQKYYL EGVSNEMYTE
560 570 580 590 600
YLSSAFVGLS FPTVCELCFV KLKLLMIAIE YKSANRESRS RKRILINPGN
610 620 630 640 650
HLKIQEGTLG FFIASDAKEV KRAFFYCKAC HDDITDPKRI KKCGCKRLED
660 670 680 690 700
EQPSTLSPKK KQRNGGMRNS PNTSPKLMRH DPLLIPGNDQ IDNMDSNVKK
710 720 730 740 750
YDSTGMFHWC APKEIEKVIL TRSEAAMTVL SGHVVVCIFG DVSSALIGLR
760 770 780 790 800
NLVMPLRASN FHYHELKHIV FVGSIEYLKR EWETLHNFPK VSILPGTPLS
810 820 830 840 850
RADLRAVNIN LCDMCVILSA NQNNIDDTSL QDKECILASL NIKSMQFDDS
860 870 880 890 900
IGVLQANSQG FTPPGMDRSS PDNSPVHGML RQPSITTGVN IPIITELVND
910 920 930 940 950
TNVQFLDQDD DDDPDTELYL TQPFACGTAF AVSVLDSLMS ATYFNDNILT
960 970 980 990 1000
LIRTLVTGGA TPELEALIAE ENALRGGYST PQTLANRDRC RVAQLALLDG
1010 1020 1030 1040 1050
PFADLGDGGC YGDLFCKALK TYNMLCFGIY RLRDAHLSTP SQCTKRYVIT
1060 1070 1080 1090 1100
NPPYEFELVP TDLIFCLMQF DHNAGQSRAS LSHSSHSSQS SSKKSSSVHS
1110 1120
IPSTANRQNR PKSRESRDKQ NRKEMVYR
Computationally mapped potential isoform sequencesi
There are 68 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ12791 | KCMA1_HUMAN | Calcium-activated potassium channel... | KCNMA1 KCNMA, SLO | 1,236 | Annotation score: | ||
B7ZMF5 | B7ZMF5_HUMAN | BK channel | KCNMA1 | 1,208 | Annotation score: | ||
Q5SVJ8 | Q5SVJ8_HUMAN | BK channel | KCNMA1 | 1,288 | Annotation score: | ||
A0A1W2PP94 | A0A1W2PP94_HUMAN | BK channel | KCNMA1 | 1,181 | Annotation score: | ||
A0A1W2PPY5 | A0A1W2PPY5_HUMAN | BK channel | KCNMA1 | 1,230 | Annotation score: | ||
A0A1W2PQK5 | A0A1W2PQK5_HUMAN | BK channel | KCNMA1 | 1,177 | Annotation score: | ||
A0A1W2PQU4 | A0A1W2PQU4_HUMAN | BK channel | KCNMA1 | 1,178 | Annotation score: | ||
A0A1W2PR56 | A0A1W2PR56_HUMAN | BK channel | KCNMA1 | 1,212 | Annotation score: | ||
H0Y379 | H0Y379_HUMAN | BK channel | KCNMA1 | 1,192 | Annotation score: | ||
J3KQ16 | J3KQ16_HUMAN | BK channel | KCNMA1 | 1,040 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011439 Genomic DNA No translation available. AC021032 Genomic DNA No translation available. AC067745 Genomic DNA No translation available. AL157833 Genomic DNA No translation available. AL607069 Genomic DNA No translation available. AL627447 Genomic DNA No translation available. AL731556 Genomic DNA No translation available. AL731560 Genomic DNA No translation available. AL731575 Genomic DNA No translation available. AB524033 mRNA Translation: BAJ07308.1 |
RefSeqi | NP_001258447.1, NM_001271518.1 |
Genome annotation databases
Ensembli | ENST00000640807; ENSP00000491555; ENSG00000156113 |
GeneIDi | 3778 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011439 Genomic DNA No translation available. AC021032 Genomic DNA No translation available. AC067745 Genomic DNA No translation available. AL157833 Genomic DNA No translation available. AL607069 Genomic DNA No translation available. AL627447 Genomic DNA No translation available. AL731556 Genomic DNA No translation available. AL731560 Genomic DNA No translation available. AL731575 Genomic DNA No translation available. AB524033 mRNA Translation: BAJ07308.1 |
RefSeqi | NP_001258447.1, NM_001271518.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | D5MRH1 |
Protocols and materials databases
Antibodypediai | 29733, 322 antibodies |
Genome annotation databases
Ensembli | ENST00000640807; ENSP00000491555; ENSG00000156113 |
GeneIDi | 3778 |
Organism-specific databases
CTDi | 3778 |
HGNCi | HGNC:6284, KCNMA1 |
OpenTargetsi | ENSG00000156113 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154935 |
OrthoDBi | 124461at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3778, 10 hits in 844 CRISPR screens |
ChiTaRSi | KCNMA1, human |
GenomeRNAii | 3778 |
Gene expression databases
ExpressionAtlasi | D5MRH1, baseline and differential |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR024939, Ca-act_K_channel_Slo-1 IPR005821, Ion_trans_dom IPR003929, K_chnl_BK_asu IPR036291, NAD(P)-bd_dom_sf IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR10027:SF28, PTHR10027:SF28, 1 hit |
Pfami | View protein in Pfam PF03493, BK_channel_a, 1 hit PF00520, Ion_trans, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D5MRH1_HUMAN | |
Accessioni | D5MRH1Primary (citable) accession number: D5MRH1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | December 2, 2020 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |