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Entry version 60 (16 Jan 2019)
Sequence version 2 (06 Feb 2013)
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Protein

La-related protein 1

Gene

larp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that promotes oogenesis by repressing fem-3 expression during germline development (PubMed:18515547, PubMed:20663921). Binds poly-U and poly-G stretches of RNA in vitro (PubMed:18515547). Regulates target RNAs expression either by regulating their stability or translation (PubMed:20663921).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • poly(G) binding Source: WormBase
  • poly(U) RNA binding Source: WormBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processDifferentiation, Oogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
La-related protein 1
Alternative name(s):
La ribonucleoprotein domain family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:larp-1
ORF Names:R144.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
R144.7a ; CE44790 ; WBGene00020097 ; larp-1
R144.7b ; CE48058 ; WBGene00020097 ; larp-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Oogenesis defects similar to defects due to hyperactive Ras-MAPK signaling. Increased mRNA levels of several components of the MAPK-signaling pathway.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004287321 – 1150La-related protein 1Add BLAST1150

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
D5MCN2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D5MCN2

PeptideAtlas

More...
PeptideAtlasi
D5MCN2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00020097 Expressed in 3 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
40913, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.R144.7b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
D5MCN2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D5MCN2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini573 – 665HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni990 – 1140Interaction with mRNABy similarityAdd BLAST151

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2590 Eukaryota
COG5193 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169209

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D5MCN2

KEGG Orthology (KO)

More...
KOi
K18757

Identification of Orthologs from Complete Genome Data

More...
OMAi
CAEMNTL

Database of Orthologous Groups

More...
OrthoDBi
230069at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006607 DM15
IPR006630 La_HTH
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05383 La, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00684 DM15, 3 hits
SM00715 LA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50961 HTH_LA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: D5MCN2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEKQPMLSF AKVVSGQAED ASSPSQQVQH TQDSSHSSTQ NENSQPEKQA
60 70 80 90 100
HPPHNRREKE NVGGRSERPR GEGKGKRRNN RKGDRKPRGE TKTEKPAEKV
110 120 130 140 150
ATEEVKPVEI PVVLEPAPLP AINAWFKNKE EAEAAAAAAQ KEQKSETAAD
160 170 180 190 200
QFIITATPVV QKSSAPIPEK KRAVEPTPKQ AAPIKEKSKS RESKKEPWKT
210 220 230 240 250
STAPAATAPV TETVTVAATQ DWPTLAKAEL NGHVSPSNSD DNNESSSNSQ
260 270 280 290 300
HKTGGKMTKN SWKKVDISVD YGSKGKGAPR GNGGEKGTRR SANDEAVRRR
310 320 330 340 350
SGEEDSASGD EQQYWSRSKD NKSPINEMSS DRVVDSGSNG IYYQQGGTHG
360 370 380 390 400
WKKKVNNKAG SDMPTPPNST SPHQSESNSP EHLPKDKAPI MNGNAKNAPA
410 420 430 440 450
ANRNGNNTST AKTGDYWHKN GGERKEDKSQ PKAYYQRNDR FQARANPHAP
460 470 480 490 500
PKLTAAQRKE RGPLPRWEDI EAGDDNFDYM TLMEAQYSQY YGAPQQFEHQ
510 520 530 540 550
LDPHQASILI QQAQQHMASF APFRPPMPML SPHLMSPPLD RDGGVTSPVS
560 570 580 590 600
NGEPINTAIP FAPIYNPPTA PRPVTDDTLK EYVRKQIEYY FSEENLQKDF
610 620 630 640 650
FLRRKMGPEG YLPVALIASF PRVRSLTEDY SLILEALKDS TKVDMSPDGL
660 670 680 690 700
QIRAPVNPTI WPLMPTVSGA DSLPGPSSQA PQQFRQNGPA ATAAPVESQP
710 720 730 740 750
QASSSKPQQP EEWEEVKTRK GKGKGRLTSG SQSTNDNKRQ PQQQQKSLQQ
760 770 780 790 800
SGSDQPDLDF QFDNEISGGG GSAQTPKRPE KSKKAFLSAI DSEEIGDDVI
810 820 830 840 850
SKLIIMTPSR RTLDRTGDFS TRSQNQGEFN EEVEIGLRRY EEELWTVPQE
860 870 880 890 900
KDIPTSKVST ISAEQFNEMR GNEDAKKTSD EPPEIPLPSG TQPTPDSVWT
910 920 930 940 950
KKAKERAAAS VTVPKSPMQR RESEEQKMNR FYPISKPTAP LDAKSPRKKK
960 970 980 990 1000
TRHSEKPPVE MPVAWVLGRE DALPAAPIGI AASSSQVPAN HPSISLLQED
1010 1020 1030 1040 1050
RFVQNVYSTW RQACLKQRKS LGYDCAEMNT LYRFWSFFLR DNFNRNMYEE
1060 1070 1080 1090 1100
FRKLALEDAE IGSRYGIEAL FRFYSYGLEK KFRPEIYKNF MKDVTTDVQK
1110 1120 1130 1140 1150
GELYGLEKLF AFLQRSKIAK QLVVDDYLTK ELNKYKSTDD FRNLPQSTKK
Length:1,150
Mass (Da):128,268
Last modified:February 6, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9E194A231DA7F92
GO
Isoform a (identifier: D5MCN2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-256: Missing.
     316-332: Missing.
     855-913: Missing.

Show »
Length:818
Mass (Da):92,316
Checksum:i8D2D346A58F30DBD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0542521 – 256Missing in isoform a. CuratedAdd BLAST256
Alternative sequenceiVSP_054253316 – 332Missing in isoform a. CuratedAdd BLAST17
Alternative sequenceiVSP_054254855 – 913Missing in isoform a. CuratedAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080694 Genomic DNA Translation: CCD65881.2
FO080694 Genomic DNA Translation: CCD65882.1

NCBI Reference Sequences

More...
RefSeqi
NP_001040867.2, NM_001047402.2 [D5MCN2-2]
NP_001040868.3, NM_001047403.4 [D5MCN2-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Cel.23170

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
R144.7a; R144.7a; WBGene00020097 [D5MCN2-2]
R144.7b.1; R144.7b.1; WBGene00020097 [D5MCN2-1]
R144.7b.2; R144.7b.2; WBGene00020097 [D5MCN2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175680

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_R144.7

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080694 Genomic DNA Translation: CCD65881.2
FO080694 Genomic DNA Translation: CCD65882.1
RefSeqiNP_001040867.2, NM_001047402.2 [D5MCN2-2]
NP_001040868.3, NM_001047403.4 [D5MCN2-1]
UniGeneiCel.23170

3D structure databases

ProteinModelPortaliD5MCN2
SMRiD5MCN2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40913, 1 interactor
STRINGi6239.R144.7b

Proteomic databases

EPDiD5MCN2
PaxDbiD5MCN2
PeptideAtlasiD5MCN2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR144.7a; R144.7a; WBGene00020097 [D5MCN2-2]
R144.7b.1; R144.7b.1; WBGene00020097 [D5MCN2-1]
R144.7b.2; R144.7b.2; WBGene00020097 [D5MCN2-1]
GeneIDi175680
KEGGicel:CELE_R144.7

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175680
WormBaseiR144.7a ; CE44790 ; WBGene00020097 ; larp-1
R144.7b ; CE48058 ; WBGene00020097 ; larp-1

Phylogenomic databases

eggNOGiKOG2590 Eukaryota
COG5193 LUCA
GeneTreeiENSGT00940000169209
InParanoidiD5MCN2
KOiK18757
OMAiCAEMNTL
OrthoDBi230069at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D5MCN2

Gene expression databases

BgeeiWBGene00020097 Expressed in 3 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR006607 DM15
IPR006630 La_HTH
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
SMARTiView protein in SMART
SM00684 DM15, 3 hits
SM00715 LA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLARP1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D5MCN2
Secondary accession number(s): H2KZ23
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: February 6, 2013
Last modified: January 16, 2019
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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