UniProtKB - D5MCN2 (LARP1_CAEEL)
Protein
La-related protein 1
Gene
larp-1
Organism
Caenorhabditis elegans
Status
Functioni
RNA-binding protein that promotes oogenesis by repressing fem-3 expression during germline development (PubMed:18515547, PubMed:20663921). Binds poly-U and poly-G stretches of RNA in vitro (PubMed:18515547). Regulates target RNAs expression either by regulating their stability or translation (PubMed:20663921).2 Publications
GO - Molecular functioni
- poly(G) binding Source: WormBase
- poly(U) RNA binding Source: WormBase
GO - Biological processi
- oogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Biological process | Differentiation, Oogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: La-related protein 1Alternative name(s): La ribonucleoprotein domain family member 1 |
Gene namesi | Name:larp-1 ORF Names:R144.7 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | R144.7a ; CE44790 ; WBGene00020097 ; larp-1 R144.7b ; CE48058 ; WBGene00020097 ; larp-1 |
Subcellular locationi
Other locations
- P-body 1 Publication
Other locations
- P-body Source: WormBase
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
Oogenesis defects similar to defects due to hyperactive Ras-MAPK signaling. Increased mRNA levels of several components of the MAPK-signaling pathway.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000428732 | 1 – 1150 | La-related protein 1Add BLAST | 1150 |
Proteomic databases
EPDi | D5MCN2 |
PaxDbi | D5MCN2 |
PeptideAtlasi | D5MCN2 |
Expressioni
Gene expression databases
Bgeei | WBGene00020097, Expressed in multi-cellular organism and 3 other tissues |
Interactioni
Protein-protein interaction databases
BioGRIDi | 40913, 11 interactors |
STRINGi | 6239.R144.7b |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 573 – 665 | HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST | 93 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 990 – 1140 | Interaction with mRNABy similarityAdd BLAST | 151 |
Phylogenomic databases
eggNOGi | KOG2590, Eukaryota |
GeneTreei | ENSGT00940000169209 |
InParanoidi | D5MCN2 |
OMAi | CAEMNTL |
OrthoDBi | 230069at2759 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR006607, DM15 IPR006630, La_HTH IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit |
SMARTi | View protein in SMART SM00684, DM15, 3 hits SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: D5MCN2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEKQPMLSF AKVVSGQAED ASSPSQQVQH TQDSSHSSTQ NENSQPEKQA
60 70 80 90 100
HPPHNRREKE NVGGRSERPR GEGKGKRRNN RKGDRKPRGE TKTEKPAEKV
110 120 130 140 150
ATEEVKPVEI PVVLEPAPLP AINAWFKNKE EAEAAAAAAQ KEQKSETAAD
160 170 180 190 200
QFIITATPVV QKSSAPIPEK KRAVEPTPKQ AAPIKEKSKS RESKKEPWKT
210 220 230 240 250
STAPAATAPV TETVTVAATQ DWPTLAKAEL NGHVSPSNSD DNNESSSNSQ
260 270 280 290 300
HKTGGKMTKN SWKKVDISVD YGSKGKGAPR GNGGEKGTRR SANDEAVRRR
310 320 330 340 350
SGEEDSASGD EQQYWSRSKD NKSPINEMSS DRVVDSGSNG IYYQQGGTHG
360 370 380 390 400
WKKKVNNKAG SDMPTPPNST SPHQSESNSP EHLPKDKAPI MNGNAKNAPA
410 420 430 440 450
ANRNGNNTST AKTGDYWHKN GGERKEDKSQ PKAYYQRNDR FQARANPHAP
460 470 480 490 500
PKLTAAQRKE RGPLPRWEDI EAGDDNFDYM TLMEAQYSQY YGAPQQFEHQ
510 520 530 540 550
LDPHQASILI QQAQQHMASF APFRPPMPML SPHLMSPPLD RDGGVTSPVS
560 570 580 590 600
NGEPINTAIP FAPIYNPPTA PRPVTDDTLK EYVRKQIEYY FSEENLQKDF
610 620 630 640 650
FLRRKMGPEG YLPVALIASF PRVRSLTEDY SLILEALKDS TKVDMSPDGL
660 670 680 690 700
QIRAPVNPTI WPLMPTVSGA DSLPGPSSQA PQQFRQNGPA ATAAPVESQP
710 720 730 740 750
QASSSKPQQP EEWEEVKTRK GKGKGRLTSG SQSTNDNKRQ PQQQQKSLQQ
760 770 780 790 800
SGSDQPDLDF QFDNEISGGG GSAQTPKRPE KSKKAFLSAI DSEEIGDDVI
810 820 830 840 850
SKLIIMTPSR RTLDRTGDFS TRSQNQGEFN EEVEIGLRRY EEELWTVPQE
860 870 880 890 900
KDIPTSKVST ISAEQFNEMR GNEDAKKTSD EPPEIPLPSG TQPTPDSVWT
910 920 930 940 950
KKAKERAAAS VTVPKSPMQR RESEEQKMNR FYPISKPTAP LDAKSPRKKK
960 970 980 990 1000
TRHSEKPPVE MPVAWVLGRE DALPAAPIGI AASSSQVPAN HPSISLLQED
1010 1020 1030 1040 1050
RFVQNVYSTW RQACLKQRKS LGYDCAEMNT LYRFWSFFLR DNFNRNMYEE
1060 1070 1080 1090 1100
FRKLALEDAE IGSRYGIEAL FRFYSYGLEK KFRPEIYKNF MKDVTTDVQK
1110 1120 1130 1140 1150
GELYGLEKLF AFLQRSKIAK QLVVDDYLTK ELNKYKSTDD FRNLPQSTKK
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054252 | 1 – 256 | Missing in isoform a. CuratedAdd BLAST | 256 | |
Alternative sequenceiVSP_054253 | 316 – 332 | Missing in isoform a. CuratedAdd BLAST | 17 | |
Alternative sequenceiVSP_054254 | 855 – 913 | Missing in isoform a. CuratedAdd BLAST | 59 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FO080694 Genomic DNA Translation: CCD65881.2 FO080694 Genomic DNA Translation: CCD65882.1 |
RefSeqi | NP_001040867.2, NM_001047402.2 [D5MCN2-2] NP_001040868.3, NM_001047403.4 [D5MCN2-1] |
Genome annotation databases
EnsemblMetazoai | R144.7a.1; R144.7a.1; WBGene00020097 [D5MCN2-2] R144.7b.1; R144.7b.1; WBGene00020097 [D5MCN2-1] R144.7b.2; R144.7b.2; WBGene00020097 [D5MCN2-1] |
GeneIDi | 175680 |
KEGGi | cel:CELE_R144.7 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FO080694 Genomic DNA Translation: CCD65881.2 FO080694 Genomic DNA Translation: CCD65882.1 |
RefSeqi | NP_001040867.2, NM_001047402.2 [D5MCN2-2] NP_001040868.3, NM_001047403.4 [D5MCN2-1] |
3D structure databases
SMRi | D5MCN2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 40913, 11 interactors |
STRINGi | 6239.R144.7b |
Proteomic databases
EPDi | D5MCN2 |
PaxDbi | D5MCN2 |
PeptideAtlasi | D5MCN2 |
Genome annotation databases
EnsemblMetazoai | R144.7a.1; R144.7a.1; WBGene00020097 [D5MCN2-2] R144.7b.1; R144.7b.1; WBGene00020097 [D5MCN2-1] R144.7b.2; R144.7b.2; WBGene00020097 [D5MCN2-1] |
GeneIDi | 175680 |
KEGGi | cel:CELE_R144.7 |
Organism-specific databases
CTDi | 175680 |
WormBasei | R144.7a ; CE44790 ; WBGene00020097 ; larp-1 R144.7b ; CE48058 ; WBGene00020097 ; larp-1 |
Phylogenomic databases
eggNOGi | KOG2590, Eukaryota |
GeneTreei | ENSGT00940000169209 |
InParanoidi | D5MCN2 |
OMAi | CAEMNTL |
OrthoDBi | 230069at2759 |
Miscellaneous databases
PROi | PR:D5MCN2 |
Gene expression databases
Bgeei | WBGene00020097, Expressed in multi-cellular organism and 3 other tissues |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR006607, DM15 IPR006630, La_HTH IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit |
SMARTi | View protein in SMART SM00684, DM15, 3 hits SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LARP1_CAEEL | |
Accessioni | D5MCN2Primary (citable) accession number: D5MCN2 Secondary accession number(s): H2KZ23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | February 6, 2013 | |
Last modified: | April 7, 2021 | |
This is version 69 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase