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UniProtKB - D5MCN2 (LARP1_CAEEL)

Entry version 60 (16 Jan 2019)
Sequence version 2 (06 Feb 2013)
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Protein

La-related protein 1

Gene

larp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that promotes oogenesis by repressing fem-3 expression during germline development (PubMed:18515547, PubMed:20663921). Binds poly-U and poly-G stretches of RNA in vitro (PubMed:18515547). Regulates target RNAs expression either by regulating their stability or translation (PubMed:20663921).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • poly(G) binding Source: WormBase
  • poly(U) RNA binding Source: WormBase
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processDifferentiation, Oogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
La-related protein 1
Alternative name(s):
La ribonucleoprotein domain family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:larp-1
ORF Names:R144.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...WormBasei		R144.7a ; CE44790 ; WBGene00020097 ; larp-1
R144.7b ; CE48058 ; WBGene00020097 ; larp-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Oogenesis defects similar to defects due to hyperactive Ras-MAPK signaling. Increased mRNA levels of several components of the MAPK-signaling pathway.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004287321 – 1150La-related protein 1Add BLAST1150

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		D5MCN2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		D5MCN2

PeptideAtlas

More...PeptideAtlasi		D5MCN2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00020097 Expressed in 3 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		40913, 1 interactor

STRING: functional protein association networks

More...STRINGi		6239.R144.7b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		D5MCN2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		D5MCN2

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini573 – 665HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni990 – 1140Interaction with mRNABy similarityAdd BLAST151

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2590 Eukaryota
COG5193 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000169209

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		D5MCN2

KEGG Orthology (KO)

More...KOi		K18757

Identification of Orthologs from Complete Genome Data

More...OMAi		CAEMNTL

Database of Orthologous Groups

More...OrthoDBi		230069at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006607 DM15
IPR006630 La_HTH
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05383 La, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00684 DM15, 3 hits
SM00715 LA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50961 HTH_LA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: D5MCN2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEKQPMLSF AKVVSGQAED ASSPSQQVQH TQDSSHSSTQ NENSQPEKQA 
        60         70         80         90        100
HPPHNRREKE NVGGRSERPR GEGKGKRRNN RKGDRKPRGE TKTEKPAEKV 
       110        120        130        140        150
ATEEVKPVEI PVVLEPAPLP AINAWFKNKE EAEAAAAAAQ KEQKSETAAD 
       160        170        180        190        200
QFIITATPVV QKSSAPIPEK KRAVEPTPKQ AAPIKEKSKS RESKKEPWKT 
       210        220        230        240        250
STAPAATAPV TETVTVAATQ DWPTLAKAEL NGHVSPSNSD DNNESSSNSQ 
       260        270        280        290        300
HKTGGKMTKN SWKKVDISVD YGSKGKGAPR GNGGEKGTRR SANDEAVRRR 
       310        320        330        340        350
SGEEDSASGD EQQYWSRSKD NKSPINEMSS DRVVDSGSNG IYYQQGGTHG 
       360        370        380        390        400
WKKKVNNKAG SDMPTPPNST SPHQSESNSP EHLPKDKAPI MNGNAKNAPA 
       410        420        430        440        450
ANRNGNNTST AKTGDYWHKN GGERKEDKSQ PKAYYQRNDR FQARANPHAP 
       460        470        480        490        500
PKLTAAQRKE RGPLPRWEDI EAGDDNFDYM TLMEAQYSQY YGAPQQFEHQ 
       510        520        530        540        550
LDPHQASILI QQAQQHMASF APFRPPMPML SPHLMSPPLD RDGGVTSPVS 
       560        570        580        590        600
NGEPINTAIP FAPIYNPPTA PRPVTDDTLK EYVRKQIEYY FSEENLQKDF 
       610        620        630        640        650
FLRRKMGPEG YLPVALIASF PRVRSLTEDY SLILEALKDS TKVDMSPDGL 
       660        670        680        690        700
QIRAPVNPTI WPLMPTVSGA DSLPGPSSQA PQQFRQNGPA ATAAPVESQP 
       710        720        730        740        750
QASSSKPQQP EEWEEVKTRK GKGKGRLTSG SQSTNDNKRQ PQQQQKSLQQ 
       760        770        780        790        800
SGSDQPDLDF QFDNEISGGG GSAQTPKRPE KSKKAFLSAI DSEEIGDDVI 
       810        820        830        840        850
SKLIIMTPSR RTLDRTGDFS TRSQNQGEFN EEVEIGLRRY EEELWTVPQE 
       860        870        880        890        900
KDIPTSKVST ISAEQFNEMR GNEDAKKTSD EPPEIPLPSG TQPTPDSVWT 
       910        920        930        940        950
KKAKERAAAS VTVPKSPMQR RESEEQKMNR FYPISKPTAP LDAKSPRKKK 
       960        970        980        990       1000
TRHSEKPPVE MPVAWVLGRE DALPAAPIGI AASSSQVPAN HPSISLLQED 
      1010       1020       1030       1040       1050
RFVQNVYSTW RQACLKQRKS LGYDCAEMNT LYRFWSFFLR DNFNRNMYEE 
      1060       1070       1080       1090       1100
FRKLALEDAE IGSRYGIEAL FRFYSYGLEK KFRPEIYKNF MKDVTTDVQK 
      1110       1120       1130       1140       1150
GELYGLEKLF AFLQRSKIAK QLVVDDYLTK ELNKYKSTDD FRNLPQSTKK
Length:1,150
Mass (Da):128,268
Last modified:February 6, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9E194A231DA7F92
GO
Isoform a (identifier: D5MCN2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-256: Missing.
     316-332: Missing.
     855-913: Missing.

Show »
Length:818
Mass (Da):92,316
Checksum:i8D2D346A58F30DBD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0542521 – 256Missing in isoform a. CuratedAdd BLAST256
Alternative sequenceiVSP_054253316 – 332Missing in isoform a. CuratedAdd BLAST17
Alternative sequenceiVSP_054254855 – 913Missing in isoform a. CuratedAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FO080694 Genomic DNA Translation: CCD65881.2
FO080694 Genomic DNA Translation: CCD65882.1

NCBI Reference Sequences

More...RefSeqi		NP_001040867.2, NM_001047402.2 [D5MCN2-2]
NP_001040868.3, NM_001047403.4 [D5MCN2-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Cel.23170

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		R144.7a; R144.7a; WBGene00020097 [D5MCN2-2]
R144.7b.1; R144.7b.1; WBGene00020097 [D5MCN2-1]
R144.7b.2; R144.7b.2; WBGene00020097 [D5MCN2-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		175680

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_R144.7

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080694 Genomic DNA Translation: CCD65881.2
FO080694 Genomic DNA Translation: CCD65882.1
RefSeqiNP_001040867.2, NM_001047402.2 [D5MCN2-2]
NP_001040868.3, NM_001047403.4 [D5MCN2-1]
UniGeneiCel.23170

3D structure databases

ProteinModelPortaliD5MCN2
SMRiD5MCN2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40913, 1 interactor
STRINGi6239.R144.7b

Proteomic databases

EPDiD5MCN2
PaxDbiD5MCN2
PeptideAtlasiD5MCN2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR144.7a; R144.7a; WBGene00020097 [D5MCN2-2]
R144.7b.1; R144.7b.1; WBGene00020097 [D5MCN2-1]
R144.7b.2; R144.7b.2; WBGene00020097 [D5MCN2-1]
GeneIDi175680
KEGGicel:CELE_R144.7

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		175680
WormBaseiR144.7a ; CE44790 ; WBGene00020097 ; larp-1
R144.7b ; CE48058 ; WBGene00020097 ; larp-1

Phylogenomic databases

eggNOGiKOG2590 Eukaryota
COG5193 LUCA
GeneTreeiENSGT00940000169209
InParanoidiD5MCN2
KOiK18757
OMAiCAEMNTL
OrthoDBi230069at2759

Miscellaneous databases

Protein Ontology

More...PROi		PR:D5MCN2

Gene expression databases

BgeeiWBGene00020097 Expressed in 3 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR006607 DM15
IPR006630 La_HTH
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
SMARTiView protein in SMART
SM00684 DM15, 3 hits
SM00715 LA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLARP1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D5MCN2
Secondary accession number(s): H2KZ23
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: February 6, 2013
Last modified: January 16, 2019
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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