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Entry version 42 (12 Aug 2020)
Sequence version 1 (15 Jun 2010)
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Protein
Submitted name:

Cobalt-zinc-cadmium resistance protein czcA

Gene

czcA

Organism
Salinibacter ruber (strain M8)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cobalt-zinc-cadmium resistance protein czcAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:czcAImported
Ordered Locus Names:SRM_00409Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalinibacter ruber (strain M8)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri761659 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000933 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei330 – 351HelicalSequence analysisAdd BLAST22
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Transmembranei384 – 409HelicalSequence analysisAdd BLAST26
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Transmembranei461 – 480HelicalSequence analysisAdd BLAST20
Transmembranei531 – 554HelicalSequence analysisAdd BLAST24
Transmembranei881 – 900HelicalSequence analysisAdd BLAST20
Transmembranei907 – 926HelicalSequence analysisAdd BLAST20
Transmembranei932 – 956HelicalSequence analysisAdd BLAST25
Transmembranei977 – 998HelicalSequence analysisAdd BLAST22
Transmembranei1010 – 1035HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002755_1_2_10

Identification of Orthologs from Complete Genome Data

More...
OMAi
IKLAFWV

Database of Orthologous Groups

More...
OrthoDBi
145346at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.2090.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027463, AcrB_DN_DC_subdom
IPR001036, Acrflvin-R

The PANTHER Classification System

More...
PANTHERi
PTHR32063, PTHR32063, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00873, ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00702, ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82714, SSF82714, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D5H5M5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRAIDWFAR HGVAANLLTM LLLVGGVVAG GLVVQENFPE FSLDAVEVRV
60 70 80 90 100
RYPGASPEDV EDDIVRRVED RIEGVEGIDR LLGTAADNIG VVTAELKRGT
110 120 130 140 150
NLDRARTDIK SEVDRVTSFP ENAEEPVVTE VTNREQVLQV ALHGEASLRA
160 170 180 190 200
LKNAAQRAEG DLTRTPQVSY AEVSGVPDEE ISIEVSRGAL RAHGLTLAQV
210 220 230 240 250
SRIVREGSLD LPAGSIETED SDITIRTEGQ NYTKSDFEDI VLLSRNDGTN
260 270 280 290 300
VLLGDVATVV DGFEQNSDLR TRFDGDPAVL LNVFRTGDEQ ALSVEEAVKT
310 320 330 340 350
YLSETLRPTL PRGIEATVWR NSAESLRTRL TIMVENGVLG LVLVLVVLTL
360 370 380 390 400
FLAPRKAFWT ASGILLSFVG ALIFMQQFGV SINMLSVFGF IIAMGIAVDD
410 420 430 440 450
AIVVVENVYA EQERTGAPLT AAVEGTQRVA TPVVFAVLTT IAAFAPLLFV
460 470 480 490 500
GGTIGKFLGD IPTVVIFVLI VSVVEVLFVL PAHLSHGTGD DGPSTAVGQW
510 520 530 540 550
LDGIRAGVHD RLVAFVHGPL TTLLRFATRR YGVTLVGGLS LLVVTFSLVA
560 570 580 590 600
NGYVKNEFFP SIPGNVVTAQ LEMPPGTNAD ETARRAERLR AQGLGVLRDL
610 620 630 640 650
EKEADERLLE NTYTTVSRQP VASGGRTQAG FTAPRPNVAE VSIEMVDAEA
660 670 680 690 700
RSVPSPVLEE QWRDTVGTPA GVQSLAFTST AGGPGGDPVS VQLFAPTVDA
710 720 730 740 750
MTRAADVVQD TLRRYAGVQD VTVDWEEKRE LSLRMKPAAR SLGLTLSDVA
760 770 780 790 800
RQVRAAFFGT ESFRLQRGED EVRVYVRLPA AQRSAVADLS DYRIRAPGGA
810 820 830 840 850
EVPLEEVATV SLGYSPTQID RQDGRRVVTV SADVNPAVTT GGATTARLER
860 870 880 890 900
ATLPALQAQV PTLSYQFGGQ QREQRKAQGS LQIGFLLALF AIYGLLAIPF
910 920 930 940 950
RSYVQPLIIM STIPFAWIGA LFGHFLLGYN LILPSIFGII GLSGVIVNDA
960 970 980 990 1000
LVMLDFANEE RGEGATWRDA LVRAGQVRFR PILLTSLTTF FGLAPFILER
1010 1020 1030 1040
SVEAQFLVPM AISLGGGILV GTAVLMLIVP ALAMLQRDVV AGLRSLF
Length:1,047
Mass (Da):112,771
Last modified:June 15, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39012D6217A2827C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FP565814 Genomic DNA Translation: CBH23330.1

NCBI Reference Sequences

More...
RefSeqi
WP_013060886.1, NC_014032.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CBH23330; CBH23330; SRM_00409

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
srm:SRM_00409

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP565814 Genomic DNA Translation: CBH23330.1
RefSeqiWP_013060886.1, NC_014032.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiCBH23330; CBH23330; SRM_00409
KEGGisrm:SRM_00409

Phylogenomic databases

HOGENOMiCLU_002755_1_2_10
OMAiIKLAFWV
OrthoDBi145346at2

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
InterProiView protein in InterPro
IPR027463, AcrB_DN_DC_subdom
IPR001036, Acrflvin-R
PANTHERiPTHR32063, PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873, ACR_tran, 1 hit
PRINTSiPR00702, ACRIFLAVINRP
SUPFAMiSSF82714, SSF82714, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD5H5M5_SALRM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D5H5M5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: August 12, 2020
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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