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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

GSTUM_00007723001

Organism
Tuber melanosporum (strain Mel28) (Perigord black truffle)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei226S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotation
LigandS-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
ORF Names:GSTUM_00007723001Imported
OrganismiTuber melanosporum (strain Mel28) (Perigord black truffle)Imported
Taxonomic identifieri656061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber
Proteomesi
  • UP000006911 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi39416.CAZ83858

Structurei

3D structure databases

ProteinModelPortaliD5GHA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 371DOT1InterPro annotationAdd BLAST324

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni177 – 180S-adenosyl-L-methionine bindingUniRule annotation4
Regioni200 – 209S-adenosyl-L-methionine bindingUniRule annotation10
Regioni262 – 263S-adenosyl-L-methionine bindingUniRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili109 – 129Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

InParanoidiD5GHA6
KOiK11427
OMAiGCEMMEN
OrthoDBiEOG092C18VU

Family and domain databases

InterProiView protein in InterPro
IPR021162 Dot1
IPR025789 DOT1_dom
IPR030445 H3-K79_meTrfase
IPR029063 SAM-dependent_MTases
PANTHERiPTHR21451 PTHR21451, 1 hit
PfamiView protein in Pfam
PF08123 DOT1, 1 hit
PIRSFiPIRSF017570 Histone_H3-K79_MeTrfase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51569 DOT1, 1 hit

Sequencei

Sequence statusi: Complete.

D5GHA6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIANMGIREG GKGPSRIFRK TDQKLLSRGI STSDLDSINP RLTAFRYELV
60 70 80 90 100
RLAEPDEFSP DLDILSTAEH VATYLLTPPE SDKLLTGTLS GSSGGIVYNM
110 120 130 140 150
RKAIRNEKAQ DFLENLNKYN NLIAKYRRDG TIKANIARMK SLPFPLVEHI
160 170 180 190 200
LSQAYARTVA PEVESLKDYE AFTSNVYGEL LPNFTTKLFR ESGLGLGKVF
210 220 230 240 250
VDLGSGTGNV VLHAALETGC EAYGCEIMKN ATRLADRQKV EFAARCRMWG
260 270 280 290 300
INPGKFRLEK GDFLESARIA EALKRADVVL VNNYVFDSEL NQRLLNLFLD
310 320 330 340 350
LKEGARILSL KPFVPINHVI TTRNAENPVS RLRVEEKEYF SGSVSWTDTG
360 370
GKYYVQTVDG SMLREFLASD RSDRRRR
Length:377
Mass (Da):42,350
Last modified:June 15, 2010 - v1
Checksum:i93AD00FDD4C668CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN430308 Genomic DNA Translation: CAZ83858.1
RefSeqiXP_002839667.1, XM_002839621.1

Genome annotation databases

EnsemblFungiiCAZ83858; CAZ83858; GSTUM_00007723001
GeneIDi9182563
KEGGitml:GSTUM_00007723001

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN430308 Genomic DNA Translation: CAZ83858.1
RefSeqiXP_002839667.1, XM_002839621.1

3D structure databases

ProteinModelPortaliD5GHA6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39416.CAZ83858

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAZ83858; CAZ83858; GSTUM_00007723001
GeneIDi9182563
KEGGitml:GSTUM_00007723001

Phylogenomic databases

InParanoidiD5GHA6
KOiK11427
OMAiGCEMMEN
OrthoDBiEOG092C18VU

Family and domain databases

InterProiView protein in InterPro
IPR021162 Dot1
IPR025789 DOT1_dom
IPR030445 H3-K79_meTrfase
IPR029063 SAM-dependent_MTases
PANTHERiPTHR21451 PTHR21451, 1 hit
PfamiView protein in Pfam
PF08123 DOT1, 1 hit
PIRSFiPIRSF017570 Histone_H3-K79_MeTrfase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51569 DOT1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD5GHA6_TUBMM
AccessioniPrimary (citable) accession number: D5GHA6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: December 20, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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