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UniProtKB - D5EE83 (D5EE83_AMICL)

Entry version 62 (02 Dec 2020)
Sequence version 1 (15 Jun 2010)
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Protein

DNA polymerase III subunit alpha

Gene

Amico_0732

Organism
Aminobacterium colombiense (strain DSM 12261 / ALA-1)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymeraseARBA annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationARBA annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		ACOL572547:G1GHU-742-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase III subunit alphaARBA annotation (EC:2.7.7.7ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Amico_0732Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAminobacterium colombiense (strain DSM 12261 / ALA-1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri572547 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Synergistetes › Synergistia › Synergistales › Synergistaceae › Aminobacterium ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002366 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		572547.Amico_0732

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 74POLIIIAcInterPro annotationAdd BLAST68

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0587, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001600_0_0_0

Identification of Orthologs from Complete Genome Data

More...OMAi		LHVHTQY

Database of Orthologous Groups

More...OrthoDBi		561611at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.1600, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011708, DNA_pol3_alpha_NTPase_dom
IPR041931, DNA_pol3_alpha_thumb_dom
IPR040982, DNA_pol3_finger
IPR029460, DNAPol_HHH
IPR004013, PHP_dom
IPR003141, Pol/His_phosphatase_N
IPR016195, Pol/histidinol_Pase-like
IPR004805, PolC_alpha

The PANTHER Classification System

More...PANTHERi		PTHR32294, PTHR32294, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07733, DNA_pol3_alpha, 1 hit
PF17657, DNA_pol3_finger, 1 hit
PF14579, HHH_6, 1 hit
PF02811, PHP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00481, POLIIIAc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF89550, SSF89550, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00594, polc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D5EE83-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTRPFVHLH VHSEYSLLDG AIRCGELAER VASWGMPAVA LTDHGAMYGA 
        60         70         80         90        100
IEFYDRCLAA GIKPIVGCEV YVDPEGHTSR EKKGRNFHLL LLAENQQGYN 
       110        120        130        140        150
NLIKLVSIAN TDGFYYRPRI DYDLLTQYSQ GIIASSACLA GEIPSLILQG 
       160        170        180        190        200
KENDALAKAH MYRDIMGEDN FFLEIMYNAI PEQAVVNRSL VQMARKNNFN 
       210        220        230        240        250
LVATNDAHYL NKEDYDWHEI LLCVQTGATI NDPDRMSFST NDFYLRSPEE 
       260        270        280        290        300
MDSLFGAELP DALDNTLAIA ERCSLKFDLG TRDYKLPSFD LPEGETLESN 
       310        320        330        340        350
LEKEAMAGLK QRLHKDNVPE EYKKRLDYEL KVIKKMGFAG YFLIVASIIR 
       360        370        380        390        400
AAKDRDIPIG PGRGSAAGSL VAYSLRITEL DPLKYNLLFE RFLNPERVSM 
       410        420        430        440        450
PDIDTDVSDK GREELLQYIA EKYGVDRVAQ IITFDRMKSK AAIRDVGRAL 
       460        470        480        490        500
GMPYSDVDVV AKLIPDGARS IPEALDQSED LRNLTHKDLA VSRLLDSASK 
       510        520        530        540        550
IEGLARHCSQ HAAGVVITPM PITDLVPVRR IGENQIVTQF PMEPLEKLGL 
       560        570        580        590        600
VKMDFLGLKT LSVLEEAINN IKLNGKTPPD LNKIPLNDNL TYEMLQRGNT 
       610        620        630        640        650
LGVFQLESTG MRQLLRKIKP DCFEDLIAVL ALYRPGPLGS GMVDQYIERK 
       660        670        680        690        700
HGRAVVEYLH PELSEVLKET YGVILYQEQV MQSAACLAGY SLGEADLLRR 
       710        720        730        740        750
AMGKKKVEVM QQQRKMFADG CAQHNVPARK AEEIFDIIQE FAGYGFNKSH 
       760        770        780        790        800
SAAYALISYQ TAYLKANFQP EFMAAYLTSQ IGSKKDVMAR YIREVRNSGI 
       810        820        830        840        850
EVLPPDVNSS MESFAAVDEV VRFGLGAVAK AGHGAVEAII AARECGGEFS 
       860        870        880        890        900
SLWNFLCRVD LRVVNKSVIE NLIKAGAFDG LNSNRRQLIS ALPDFVALAQ 
       910        920        930        940        950
RKGEEKNQCS LLSLLDEDSE SGDLEPELPD IEDYAIYERL DMEKEVVGLY 
       960        970        980        990       1000
ISGHPFTQHE TLVSRYSTCS ISNLKYWRSR NLFPQIGGMI LSVHEKYTKR 
      1010       1020       1030       1040       1050
GDPMGILEVE DAESKLEVIC FPKIWSSIKD QIEPGEICII RGTLDERGSG 
      1060       1070       1080       1090       1100
NIIAKEIVSF QAIQGKMPPF VKIVLDGTLL QPNSMKNFIR SLKDFPGRSQ 
      1110       1120       1130       1140 
VLLEIRNGVG SVVILLSGIK VDGPTIKSKG LAPALPEEAY EVFC
Length:1,144
Mass (Da):127,620
Last modified:June 15, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i474232E2F97E001C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CP001997 Genomic DNA Translation: ADE56865.1

NCBI Reference Sequences

More...RefSeqi		WP_013048131.1, NC_014011.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		ADE56865; ADE56865; Amico_0732

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		aco:Amico_0732

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001997 Genomic DNA Translation: ADE56865.1
RefSeqiWP_013048131.1, NC_014011.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi572547.Amico_0732

Genome annotation databases

EnsemblBacteriaiADE56865; ADE56865; Amico_0732
KEGGiaco:Amico_0732

Phylogenomic databases

eggNOGiCOG0587, Bacteria
HOGENOMiCLU_001600_0_0_0
OMAiLHVHTQY
OrthoDBi561611at2

Enzyme and pathway databases

BioCyciACOL572547:G1GHU-742-MONOMER

Family and domain databases

Gene3Di1.10.10.1600, 1 hit
InterProiView protein in InterPro
IPR011708, DNA_pol3_alpha_NTPase_dom
IPR041931, DNA_pol3_alpha_thumb_dom
IPR040982, DNA_pol3_finger
IPR029460, DNAPol_HHH
IPR004013, PHP_dom
IPR003141, Pol/His_phosphatase_N
IPR016195, Pol/histidinol_Pase-like
IPR004805, PolC_alpha
PANTHERiPTHR32294, PTHR32294, 1 hit
PfamiView protein in Pfam
PF07733, DNA_pol3_alpha, 1 hit
PF17657, DNA_pol3_finger, 1 hit
PF14579, HHH_6, 1 hit
PF02811, PHP, 1 hit
SMARTiView protein in SMART
SM00481, POLIIIAc, 1 hit
SUPFAMiSSF89550, SSF89550, 1 hit
TIGRFAMsiTIGR00594, polc, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD5EE83_AMICL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D5EE83
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: December 2, 2020
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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