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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Sideroxydans lithotrophicus (strain ES-1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotationSAAS annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotationSAAS annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei151May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSLIT580332:G1GHN-707-MONOMER
UniPathwayi
UPA00848;UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Slit_0707Imported
OrganismiSideroxydans lithotrophicus (strain ES-1)Imported
Taxonomic identifieri580332 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesGallionellaceaeSideroxydans
Proteomesi
  • UP000001625 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi580332.Slit_0707

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000280679
KOiK09007
OMAiHNQRGRG
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
TIGRFAMsiTIGR00294 TIGR00294, 1 hit

Sequencei

Sequence statusi: Complete.

D5CNN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSIETIADV QNSADTRQLA INKVGIKSIR HPVVVKDKSE GVQHTIATFN
60 70 80 90 100
MYVHLPHNFK GTHMSRFVQI LNQHGREISV ESFEGILREM TEKLEAKSGY
110 120 130 140 150
IEMSFPYFVN KTAPISEVQS LLDYDVTFIG EIVDGNYRFN MKVQIPVTSL
160 170 180 190 200
CPCSKEISER GAHNQRSHVT ITVRTRRSVW IEEVVRFAEE QASSELYGLL
210 220 230 240 250
KRPDEKFVTE RAYDNPKFVE DMVRDVAAVL NADERIEAYI VESENFESIH
260
NHSAYALIER DKTKD
Length:265
Mass (Da):30,399
Last modified:June 15, 2010 - v1
Checksum:i4772A438A3E6A5D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001965 Genomic DNA Translation: ADE10946.1
RefSeqiWP_013028845.1, NC_013959.1

Genome annotation databases

EnsemblBacteriaiADE10946; ADE10946; Slit_0707
KEGGislt:Slit_0707

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001965 Genomic DNA Translation: ADE10946.1
RefSeqiWP_013028845.1, NC_013959.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi580332.Slit_0707

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE10946; ADE10946; Slit_0707
KEGGislt:Slit_0707

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000280679
KOiK09007
OMAiHNQRGRG
OrthoDBiPOG091H0MIO

Enzyme and pathway databases

UniPathwayi
UPA00848;UER00151

BioCyciSLIT580332:G1GHN-707-MONOMER

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
TIGRFAMsiTIGR00294 TIGR00294, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD5CNN3_SIDLE
AccessioniPrimary (citable) accession number: D5CNN3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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