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Entry version 74 (02 Jun 2021)
Sequence version 1 (15 Jun 2010)
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Protein
Submitted name:

ATPase, P-type (Transporting), HAD superfamily, subfamily IC

Gene

Nhal_1826

Organism
Nitrosococcus halophilus (strain Nc4)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocaseARBA annotation
LigandATP-bindingARBA annotation, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.3.2.29, the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATPase, P-type (Transporting), HAD superfamily, subfamily ICImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Nhal_1826Imported, Nhal_1845Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNitrosococcus halophilus (strain Nc4)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri472759 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeNitrosococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001844 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei57 – 79HelicalSequence analysisAdd BLAST23
Transmembranei85 – 101HelicalSequence analysisAdd BLAST17
Transmembranei248 – 270HelicalSequence analysisAdd BLAST23
Transmembranei276 – 300HelicalSequence analysisAdd BLAST25
Transmembranei693 – 718HelicalSequence analysisAdd BLAST26
Transmembranei724 – 742HelicalSequence analysisAdd BLAST19
Transmembranei762 – 785HelicalSequence analysisAdd BLAST24
Transmembranei797 – 815HelicalSequence analysisAdd BLAST19
Transmembranei835 – 853HelicalSequence analysisAdd BLAST19
Transmembranei859 – 884HelicalSequence analysisAdd BLAST26
Transmembranei918 – 938HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
472759.Nhal_1845

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1030 – 1079LysMInterPro annotationAdd BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni955 – 1034DisorderedSequence analysisAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi969 – 983Polar residuesSequence analysisAdd BLAST15
Compositional biasi993 – 1024Basic and acidic residuesSequence analysisAdd BLAST32

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0474, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002360_2_1_6

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPPTPLW

Database of Orthologous Groups

More...
OrthoDBi
178322at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00118, LysM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.350.10, 1 hit
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006068, ATPase_P-typ_cation-transptr_C
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR018392, LysM_dom
IPR036779, LysM_dom_sf
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00689, Cation_ATPase_C, 1 hit
PF00690, Cation_ATPase_N, 1 hit
PF01476, LysM, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00120, HATPASE

Structure-Function Linkage Database

More...
SFLDi
SFLDF00027, p-type_atpase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00831, Cation_ATPase_N, 1 hit
SM00257, LysM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01494, ATPase_P-type, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit
PS51782, LYSM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D5C355-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSVKQESGH AHTVEAVLQR IGSDRLGLTQ SEAEQRLQQY GPNRLTPPKR
60 70 80 90 100
RGPIERFLVQ FHNVLIYVLL AAAVVTALLA HWVDTGVILG VVVLNALIGF
110 120 130 140 150
IQEGKAEQAL EALRHLLSPQ ASVLRDGRHR MIPAEQLVPG DVVTLQSGDK
160 170 180 190 200
VPADLRLIRV KNLRIEEAAL TGESMPVEKA LEPVAENASL GDRTNMAYSG
210 220 230 240 250
TLVTYGTAEG VVVATGDHTE IGRISAMLGQ VQTLTTPLLR QMAVFGRWLT
260 270 280 290 300
AVILGVAAAV FAFGVGVRGY SFHEMFLAAV GLAVAAIPEG LPAIMTITLA
310 320 330 340 350
MGVQRMARRN AIIRRLPAVE TLGSVNVICS DKTGTLTRNE MTVRTVITAD
360 370 380 390 400
AGFEISGVGY NPHGGFSQQG QIILMDDYPG LGELCRAGLL CNDAILHNVE
410 420 430 440 450
ATWVIQGDPT EAALVSLAMK ANLLPEWERE EWQRVDVIPF ESEHRFMATL
460 470 480 490 500
HHDRVGHAFI YLKGAPEQVL EMCHHQRSRG EDEPLDLPYW HDRILEMASR
510 520 530 540 550
GERVLAVAFR VTHTDHCNLR FEDVQEGLTL LGLFGIIDPP REEAIAAVKE
560 570 580 590 600
CQEAGIRVKM ITGDHLLTAQ AISRQLGLKH SDQALAGTKL EVMDDETLRN
610 620 630 640 650
VILDVDVFAR ASPEHKLRLV KALQSQGRVV AMTGDGVNDA PALKRADVGI
660 670 680 690 700
AMGQKGTEVA KEAAEAVLAD DNFASIAQAV KEGRTVYDNL KKAILFILPT
710 720 730 740 750
NGGEAMALVA AILLGYMLPI TPVQILWINM VTAVTLALAL AFEPPEGNVM
760 770 780 790 800
RRPPREPGEP VLSGFLVWRI VFVSVILVVG TFGLFLWYRE QGAPIEYART
810 820 830 840 850
IAVNTLVMFE IFYLLNTRYM TNSVLSREGL LGNRYVLIAI AVVVGLQLLF
860 870 880 890 900
TYTGPMQQLF ASVALGLHDW GWIVLVTSSV FVLVELEKSF LRRRKEKAPP
910 920 930 940 950
RRVEPPVAAF ERFKPRRVWP AALILLLLGV GVGSWIWVQF EGEEKEAIVV
960 970 980 990 1000
AEAERQARPP AEPLPDTQTP GVKTPSDRET TPAPQQPEVA AIPLPEKEKE
1010 1020 1030 1040 1050
VPERPEMVPK PPIKEVEEEP EQIEVSPAAK TVTVQPGDTL SQIAARAYGD
1060 1070 1080
PTQWPLIYEA NRGKIENPNV IIPGMELTLP PAPKNQD
Length:1,087
Mass (Da):119,163
Last modified:June 15, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FD3A8A1EACA23CE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP001798 Genomic DNA Translation: ADE14947.1
CP001798 Genomic DNA Translation: ADE14963.1

NCBI Reference Sequences

More...
RefSeqi
WP_013032832.1, NC_013960.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ADE14947; ADE14947; Nhal_1826
ADE14963; ADE14963; Nhal_1845

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nhl:Nhal_1826
nhl:Nhal_1845

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001798 Genomic DNA Translation: ADE14947.1
CP001798 Genomic DNA Translation: ADE14963.1
RefSeqiWP_013032832.1, NC_013960.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi472759.Nhal_1845

Protein family/group databases

TCDBi3.A.3.2.29, the p-type atpase (p-atpase) superfamily

Genome annotation databases

EnsemblBacteriaiADE14947; ADE14947; Nhal_1826
ADE14963; ADE14963; Nhal_1845
KEGGinhl:Nhal_1826
nhl:Nhal_1845

Phylogenomic databases

eggNOGiCOG0474, Bacteria
HOGENOMiCLU_002360_2_1_6
OMAiDPPTPLW
OrthoDBi178322at2

Family and domain databases

CDDicd00118, LysM, 1 hit
Gene3Di3.10.350.10, 1 hit
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006068, ATPase_P-typ_cation-transptr_C
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR018392, LysM_dom
IPR036779, LysM_dom_sf
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom
PfamiView protein in Pfam
PF00689, Cation_ATPase_C, 1 hit
PF00690, Cation_ATPase_N, 1 hit
PF01476, LysM, 1 hit
PRINTSiPR00120, HATPASE
SFLDiSFLDF00027, p-type_atpase, 1 hit
SMARTiView protein in SMART
SM00831, Cation_ATPase_N, 1 hit
SM00257, LysM, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit
TIGRFAMsiTIGR01494, ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit
PS51782, LYSM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD5C355_NITHN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D5C355
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: June 2, 2021
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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