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Protein

Alanine racemase

Gene

SAR116_0646

Organism
Puniceispirillum marinum (strain IMCC1322)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (SAR116_0646)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei48Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Active sitei278Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei326Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCPUN488538:G1GG6-664-MONOMER
UniPathwayi
UPA00042;UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:SAR116_0646Imported
OrganismiPuniceispirillum marinum (strain IMCC1322)Imported
Taxonomic identifieri488538 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR116 clusterCandidatus Puniceispirillum
Proteomesi
  • UP000007460 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi488538.SAR116_0646

Structurei

3D structure databases

ProteinModelPortaliD5BRJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini257 – 383Ala_racemase_CInterPro annotationAdd BLAST127

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031445
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit

Sequencei

Sequence statusi: Complete.

D5BRJ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTGDENVLA AFGAADNRID IDLGAIAHNW LYLDSLSPKS TITAAMVKAN
60 70 80 90 100
GYGLGANHVG AALYKAGCRQ FFVANLDEAV SFRTYLDNIS ISDAQIMVLH
110 120 130 140 150
GCHRGQEHDM RAYRLTPVLN DLEQVSRWRL YAQNANETYP AMLHLDTGMT
160 170 180 190 200
RLGFDPDQTD WLIENKQALN GLEITYIMSH LISGEISDDP ANTAQKTRFD
210 220 230 240 250
EYRSFFGGIK ASLANSGGVF LGNEFHYQMT RPGIAIYGVH PCGKDQAITD
260 270 280 290 300
SNGLKSCITW HGRIIQVRTA PEGATVGYGG THRLSRPSRI ATVGVGYADG
310 320 330 340 350
YQRNLSNKAF VNILGHRAPV IGRISMDSIT IDVTDIPPNI MLKAETAALL
360 370 380
SDLYSIEDMA NDASTIPYEI LTGISRRAIR RYI
Length:383
Mass (Da):42,040
Last modified:June 15, 2010 - v1
Checksum:iC94F1188C70B9228
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001751 Genomic DNA Translation: ADE38889.1
RefSeqiWP_013045518.1, NC_014010.1

Genome annotation databases

EnsemblBacteriaiADE38889; ADE38889; SAR116_0646
KEGGiapb:SAR116_0646

Similar proteinsi

Entry informationi

Entry nameiD5BRJ2_PUNMI
AccessioniPrimary (citable) accession number: D5BRJ2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: September 12, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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