UniProtKB - D4PHA7 (WSCD2_MOUSE)
Protein
WSC domain-containing protein 2
Gene
Wscd2
Organism
Mus musculus (Mouse)
Status
Functioni
Names & Taxonomyi
Protein namesi | Recommended name: WSC domain-containing protein 2 |
Gene namesi | Name:Wscd2 Synonyms:Kiaa0789 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2445030, Wscd2 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 21 – 43 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000416124 | 1 – 571 | WSC domain-containing protein 2Add BLAST | 571 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 195 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 248 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | D4PHA7 |
PRIDEi | D4PHA7 |
ProteomicsDBi | 297859 [D4PHA7-1] 297860 [D4PHA7-2] |
TopDownProteomicsi | D4PHA7-1 [D4PHA7-1] |
PTM databases
GlyGeni | D4PHA7, 2 sites |
iPTMneti | D4PHA7 |
PhosphoSitePlusi | D4PHA7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000063430, Expressed in epithelium of cochlear duct and 211 other tissues |
Genevisiblei | D4PHA7, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000092021 |
Miscellaneous databases
RNActi | D4PHA7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 133 – 225 | WSC 1PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 236 – 330 | WSC 2PROSITE-ProRule annotationAdd BLAST | 95 |
Sequence similaritiesi
Belongs to the WSCD family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4157, Eukaryota |
GeneTreei | ENSGT00940000159434 |
HOGENOMi | CLU_029239_0_0_1 |
InParanoidi | D4PHA7 |
OMAi | QNMSVDK |
OrthoDBi | 809004at2759 |
PhylomeDBi | D4PHA7 |
TreeFami | TF324060 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR002889, WSC_carb-bd |
Pfami | View protein in Pfam PF01822, WSC, 2 hits |
SMARTi | View protein in SMART SM00321, WSC, 2 hits |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51212, WSC, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: D4PHA7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAKLWFKFQR CFRYFRRKPV RFFTLLAIYL TAGSLVFLHS GFVGQPAVPQ
60 70 80 90 100
SQASPAAGSP VEGAELPFLG DLHLGRGFRD TVEASSIARR YGPTFKGKDT
110 120 130 140 150
SERAKLGDYG GAWSRALKGR VVREKEKEKE EEKAKYIGCY LDDTQSRALR
160 170 180 190 200
GVSFFDYKKM TVFRCQDNCA ERGYLYAGLE FGAECYCGHK IQAANVSESD
210 220 230 240 250
CDMECKGERG SVCGGINRLS VYRLQLAQES ARRYGSAVFR GCFRRPNNLS
260 270 280 290 300
LALPVSAAMP NMSVDKCVDL CTEKEFPLAA LAGTACHCGF PTTRFPLHDR
310 320 330 340 350
EDEQLCAQKC SAEEFESCGT PSYFIVYQTQ VQDNRCMDRR FLPAKSKKLI
360 370 380 390 400
ALASFPGAGN TWARHLIELA TGFYTGSYYF DGSLYNKGFK GERDHWRSGR
410 420 430 440 450
TICIKTHESG QKEIEAFDAA ILLIRNPYKA LMAEFNRKYG GHIGFAAHAH
460 470 480 490 500
WKGKEWPEFV RNYAPWWATH TLDWLKFGKT VLVVHFEDLK QDLFTQLGRM
510 520 530 540 550
VSLLGVAVRE DRLLCVESQK DGNFKRSGLR KLEYDPYTAE MRRTIAAYIR
560 570
MVDTALRSRN LTGVPDAYGP R
Sequence cautioni
The sequence BAD32304 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042508 | 134 – 195 | AKYIG…IQAAN → GKVLEGLRENTGTNVEITAT KLVSLLQTHVNVGTLDLSSI ISESHSYSLIGKFHLNPTLA LV in isoform 2. 3 PublicationsAdd BLAST | 62 | |
Alternative sequenceiVSP_042509 | 196 – 571 | Missing in isoform 2. 3 PublicationsAdd BLAST | 376 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK173026 mRNA Translation: BAD32304.1 Different initiation. AK049685 mRNA Translation: BAC33871.1 AC121909 Genomic DNA No translation available. CAAA01026602 Genomic DNA No translation available. CAAA01091397 Genomic DNA No translation available. CAAA01144085 Genomic DNA No translation available. CAAA01166320 Genomic DNA No translation available. CAAA01167025 Genomic DNA No translation available. CAAA01189638 Genomic DNA No translation available. CH466529 Genomic DNA Translation: EDL19945.1 CH466529 Genomic DNA Translation: EDL19946.1 BC096526 mRNA No translation available. BC147280 mRNA Translation: AAI47281.1 BC147281 mRNA Translation: AAI47282.1 |
CCDSi | CCDS19550.2 [D4PHA7-1] |
RefSeqi | NP_796266.2, NM_177292.3 [D4PHA7-1] XP_017176417.1, XM_017320928.1 [D4PHA7-1] |
Genome annotation databases
Ensembli | ENSMUST00000094452; ENSMUSP00000092021; ENSMUSG00000063430 [D4PHA7-1] |
GeneIDi | 320916 |
KEGGi | mmu:320916 |
UCSCi | uc029vmo.1, mouse [D4PHA7-2] uc029vmp.1, mouse [D4PHA7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK173026 mRNA Translation: BAD32304.1 Different initiation. AK049685 mRNA Translation: BAC33871.1 AC121909 Genomic DNA No translation available. CAAA01026602 Genomic DNA No translation available. CAAA01091397 Genomic DNA No translation available. CAAA01144085 Genomic DNA No translation available. CAAA01166320 Genomic DNA No translation available. CAAA01167025 Genomic DNA No translation available. CAAA01189638 Genomic DNA No translation available. CH466529 Genomic DNA Translation: EDL19945.1 CH466529 Genomic DNA Translation: EDL19946.1 BC096526 mRNA No translation available. BC147280 mRNA Translation: AAI47281.1 BC147281 mRNA Translation: AAI47282.1 |
CCDSi | CCDS19550.2 [D4PHA7-1] |
RefSeqi | NP_796266.2, NM_177292.3 [D4PHA7-1] XP_017176417.1, XM_017320928.1 [D4PHA7-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000092021 |
PTM databases
GlyGeni | D4PHA7, 2 sites |
iPTMneti | D4PHA7 |
PhosphoSitePlusi | D4PHA7 |
Proteomic databases
PaxDbi | D4PHA7 |
PRIDEi | D4PHA7 |
ProteomicsDBi | 297859 [D4PHA7-1] 297860 [D4PHA7-2] |
TopDownProteomicsi | D4PHA7-1 [D4PHA7-1] |
Protocols and materials databases
Antibodypediai | 2240, 90 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000094452; ENSMUSP00000092021; ENSMUSG00000063430 [D4PHA7-1] |
GeneIDi | 320916 |
KEGGi | mmu:320916 |
UCSCi | uc029vmo.1, mouse [D4PHA7-2] uc029vmp.1, mouse [D4PHA7-1] |
Organism-specific databases
CTDi | 9671 |
MGIi | MGI:2445030, Wscd2 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG4157, Eukaryota |
GeneTreei | ENSGT00940000159434 |
HOGENOMi | CLU_029239_0_0_1 |
InParanoidi | D4PHA7 |
OMAi | QNMSVDK |
OrthoDBi | 809004at2759 |
PhylomeDBi | D4PHA7 |
TreeFami | TF324060 |
Miscellaneous databases
BioGRID-ORCSi | 320916, 1 hit in 41 CRISPR screens |
ChiTaRSi | Wscd2, mouse |
PROi | PR:D4PHA7 |
RNActi | D4PHA7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000063430, Expressed in epithelium of cochlear duct and 211 other tissues |
Genevisiblei | D4PHA7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR002889, WSC_carb-bd |
Pfami | View protein in Pfam PF01822, WSC, 2 hits |
SMARTi | View protein in SMART SM00321, WSC, 2 hits |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51212, WSC, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WSCD2_MOUSE | |
Accessioni | D4PHA7Primary (citable) accession number: D4PHA7 Secondary accession number(s): Q69ZZ2, Q8C7Q3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2012 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families