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UniProtKB - D4PHA7 (WSCD2_MOUSE)

Entry version 58 (16 Jan 2019)
Sequence version 1 (18 May 2010)
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Protein

WSC domain-containing protein 2

Gene

Wscd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WSC domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Wscd2
Synonyms:Kiaa0789
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2445030 Wscd2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 43HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004161241 – 571WSC domain-containing protein 2Add BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		D4PHA7

PRoteomics IDEntifications database

More...PRIDEi		D4PHA7

Consortium for Top Down Proteomics

More...TopDownProteomicsi		D4PHA7-1 [D4PHA7-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		D4PHA7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		D4PHA7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000063430 Expressed in 187 organ(s), highest expression level in epithelium of cochlear duct

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		D4PHA7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000092021

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		D4PHA7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		D4PHA7

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini133 – 225WSC 1PROSITE-ProRule annotationAdd BLAST93
Domaini236 – 330WSC 2PROSITE-ProRule annotationAdd BLAST95

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WSCD family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4157 Eukaryota
ENOG4111FP9 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159434

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000060082

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG070170

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		D4PHA7

Identification of Orthologs from Complete Genome Data

More...OMAi		KCVDLCT

Database of Orthologous Groups

More...OrthoDBi		809004at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		D4PHA7

TreeFam database of animal gene trees

More...TreeFami		TF324060

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417 P-loop_NTPase
IPR002889 WSC_carb-bd

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01822 WSC, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00321 WSC, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51212 WSC, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: D4PHA7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKLWFKFQR CFRYFRRKPV RFFTLLAIYL TAGSLVFLHS GFVGQPAVPQ 
        60         70         80         90        100
SQASPAAGSP VEGAELPFLG DLHLGRGFRD TVEASSIARR YGPTFKGKDT 
       110        120        130        140        150
SERAKLGDYG GAWSRALKGR VVREKEKEKE EEKAKYIGCY LDDTQSRALR 
       160        170        180        190        200
GVSFFDYKKM TVFRCQDNCA ERGYLYAGLE FGAECYCGHK IQAANVSESD 
       210        220        230        240        250
CDMECKGERG SVCGGINRLS VYRLQLAQES ARRYGSAVFR GCFRRPNNLS 
       260        270        280        290        300
LALPVSAAMP NMSVDKCVDL CTEKEFPLAA LAGTACHCGF PTTRFPLHDR 
       310        320        330        340        350
EDEQLCAQKC SAEEFESCGT PSYFIVYQTQ VQDNRCMDRR FLPAKSKKLI 
       360        370        380        390        400
ALASFPGAGN TWARHLIELA TGFYTGSYYF DGSLYNKGFK GERDHWRSGR 
       410        420        430        440        450
TICIKTHESG QKEIEAFDAA ILLIRNPYKA LMAEFNRKYG GHIGFAAHAH 
       460        470        480        490        500
WKGKEWPEFV RNYAPWWATH TLDWLKFGKT VLVVHFEDLK QDLFTQLGRM 
       510        520        530        540        550
VSLLGVAVRE DRLLCVESQK DGNFKRSGLR KLEYDPYTAE MRRTIAAYIR 
       560        570 
MVDTALRSRN LTGVPDAYGP R
Length:571
Mass (Da):64,598
Last modified:May 18, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i835EC3FFF086CAEB
GO
Isoform 2 (identifier: D4PHA7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-195: AKYIGCYLDD...YCGHKIQAAN → GKVLEGLREN...FHLNPTLALV
     196-571: Missing.

Note: May be due to an intron retention.
Show »
Length:195
Mass (Da):21,557
Checksum:i4438DFD3CE79B604
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32304 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042508134 – 195AKYIG…IQAAN → GKVLEGLRENTGTNVEITAT KLVSLLQTHVNVGTLDLSSI ISESHSYSLIGKFHLNPTLA LV in isoform 2. 3 PublicationsAdd BLAST62
Alternative sequenceiVSP_042509196 – 571Missing in isoform 2. 3 PublicationsAdd BLAST376

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK173026 mRNA Translation: BAD32304.1 Different initiation.
AK049685 mRNA Translation: BAC33871.1
AC121909 Genomic DNA No translation available.
CAAA01026602 Genomic DNA No translation available.
CAAA01091397 Genomic DNA No translation available.
CAAA01144085 Genomic DNA No translation available.
CAAA01166320 Genomic DNA No translation available.
CAAA01167025 Genomic DNA No translation available.
CAAA01189638 Genomic DNA No translation available.
CH466529 Genomic DNA Translation: EDL19945.1
CH466529 Genomic DNA Translation: EDL19946.1
BC096526 mRNA No translation available.
BC147280 mRNA Translation: AAI47281.1
BC147281 mRNA Translation: AAI47282.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS19550.2 [D4PHA7-1]

NCBI Reference Sequences

More...RefSeqi		NP_796266.2, NM_177292.3 [D4PHA7-1]
XP_017176417.1, XM_017320928.1 [D4PHA7-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Mm.102783

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000094452; ENSMUSP00000092021; ENSMUSG00000063430 [D4PHA7-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		320916

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:320916

UCSC genome browser

More...UCSCi		uc029vmo.1 mouse [D4PHA7-2]
uc029vmp.1 mouse [D4PHA7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173026 mRNA Translation: BAD32304.1 Different initiation.
AK049685 mRNA Translation: BAC33871.1
AC121909 Genomic DNA No translation available.
CAAA01026602 Genomic DNA No translation available.
CAAA01091397 Genomic DNA No translation available.
CAAA01144085 Genomic DNA No translation available.
CAAA01166320 Genomic DNA No translation available.
CAAA01167025 Genomic DNA No translation available.
CAAA01189638 Genomic DNA No translation available.
CH466529 Genomic DNA Translation: EDL19945.1
CH466529 Genomic DNA Translation: EDL19946.1
BC096526 mRNA No translation available.
BC147280 mRNA Translation: AAI47281.1
BC147281 mRNA Translation: AAI47282.1
CCDSiCCDS19550.2 [D4PHA7-1]
RefSeqiNP_796266.2, NM_177292.3 [D4PHA7-1]
XP_017176417.1, XM_017320928.1 [D4PHA7-1]
UniGeneiMm.102783

3D structure databases

ProteinModelPortaliD4PHA7
SMRiD4PHA7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092021

PTM databases

iPTMnetiD4PHA7
PhosphoSitePlusiD4PHA7

Proteomic databases

PaxDbiD4PHA7
PRIDEiD4PHA7
TopDownProteomicsiD4PHA7-1 [D4PHA7-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094452; ENSMUSP00000092021; ENSMUSG00000063430 [D4PHA7-1]
GeneIDi320916
KEGGimmu:320916
UCSCiuc029vmo.1 mouse [D4PHA7-2]
uc029vmp.1 mouse [D4PHA7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9671
MGIiMGI:2445030 Wscd2

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG4157 Eukaryota
ENOG4111FP9 LUCA
GeneTreeiENSGT00940000159434
HOGENOMiHOG000060082
HOVERGENiHBG070170
InParanoidiD4PHA7
OMAiKCVDLCT
OrthoDBi809004at2759
PhylomeDBiD4PHA7
TreeFamiTF324060

Miscellaneous databases

Protein Ontology

More...PROi		PR:D4PHA7

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000063430 Expressed in 187 organ(s), highest expression level in epithelium of cochlear duct
GenevisibleiD4PHA7 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR002889 WSC_carb-bd
PfamiView protein in Pfam
PF01822 WSC, 2 hits
SMARTiView protein in SMART
SM00321 WSC, 2 hits
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51212 WSC, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWSCD2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4PHA7
Secondary accession number(s): Q69ZZ2, Q8C7Q3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: May 18, 2010
Last modified: January 16, 2019
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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