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Entry version 69 (12 Aug 2020)
Sequence version 1 (18 May 2010)
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Protein

Phenylalanine--tRNA ligase beta subunit

Gene

pheT

Organism
Faecalibacterium prausnitzii SL3/3
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per tetramer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi462MagnesiumUniRule annotation1
Metal bindingi468Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi471MagnesiumUniRule annotation1
Metal bindingi472MagnesiumUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImportedARBA annotation, Ligase, RNA-binding, tRNA-bindingPROSITE-ProRule annotationARBA annotation
Biological processProtein biosynthesisUniRule annotationARBA annotation
LigandATP-bindingUniRule annotationARBA annotation, MagnesiumUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunitUniRule annotation (EC:6.1.1.20UniRule annotation)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunitUniRule annotation
Short name:
PheRSUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pheTUniRule annotation
ORF Names:FPR_24740Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFaecalibacterium prausnitzii SL3/3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri657322 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeFaecalibacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007059 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
D4KCR6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer of two alpha and two beta subunits.

UniRule annotationARBA annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
657322.FPR_24740

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 154TRNA-bindingInterPro annotationAdd BLAST116
Domaini408 – 484B5InterPro annotationAdd BLAST77
Domaini711 – 803FDX-ACBInterPro annotationAdd BLAST93

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0072, Bacteria
COG0073, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016891_0_0_9

KEGG Orthology (KO)

More...
KOi
K01890

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00769, PheRS_beta_core, 1 hit
cd02796, tRNA_bind_bactPheRS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.380, 1 hit
3.50.40.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00283, Phe_tRNA_synth_beta1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005146, B3/B4_tRNA-bd
IPR009061, DNA-bd_dom_put_sf
IPR005121, Fdx_antiC-bd
IPR036690, Fdx_antiC-bd_sf
IPR012340, NA-bd_OB-fold
IPR004532, Phe-tRNA-ligase_IIc_bsu
IPR020825, Phe-tRNA_synthase_B3/B4
IPR041616, PheRS_beta_core
IPR002547, tRNA-bd_dom
IPR033714, tRNA_bind_bactPheRS
IPR005147, tRNA_synthase_B5-dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03483, B3_4, 1 hit
PF03484, B5, 1 hit
PF03147, FDX-ACB, 1 hit
PF01588, tRNA_bind, 1 hit
PF17759, tRNA_synthFbeta, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00873, B3_4, 1 hit
SM00874, B5, 1 hit
SM00896, FDX-ACB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46955, SSF46955, 1 hit
SSF50249, SSF50249, 1 hit
SSF54991, SSF54991, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00472, pheT_bact, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51483, B5, 1 hit
PS51447, FDX_ACB, 1 hit
PS50886, TRBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4KCR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVPFSWLKE FVDIDVTAQE LEEKLFSCGF EVEELIPLDA GISKVVVGKI
60 70 80 90 100
VEMEKQEGTH LTKCVVDCGA YGHEIRISTG AANMKLGDCV PTALDGSTLP
110 120 130 140 150
GGITIKARKM QGVESNGMLC SGAELGLNDD LFPGSEVYGL LILPEDSVPG
160 170 180 190 200
TDIAPVVGLD DYIFDISITA NRPDCQSVLG IAREVAAVLG KPLHMPAMDY
210 220 230 240 250
KAVCEPDAPI TVKVEAPELC PRYMAHYVRN IRMGESPRWM KRHLALCGLR
260 270 280 290 300
SISNVVDITN HTLLEMGQPM HAFDLNKVAG RTIDVRRAHE GEKIVTLDEK
310 320 330 340 350
EFTLNPNNLV ICDAEKPVAL AGIMGGANSG MDDNTTSLLF ECATFARDSV
360 370 380 390 400
RKTSRALGQN SDSSARYEKG VDRYSPQLGL ARALHLIQQL DCGDITTLEY
410 420 430 440 450
DLTDGRPLER KHIVATPAKI CGVLGITVPD QTMIDILQRL EFTVDVQADG
460 470 480 490 500
SWDVSAPLYR DDVESFPDLA EEVIREYGYD HIVPTFLNTA SVTNGGLNYD
510 520 530 540 550
QKQQLKTKRL LAAQGFYEAS TLAFYSNAEL DMLHIPAEDE ARKAIRILNP
560 570 580 590 600
ISENLSIMRT LLTPSMLNVI VDNLKKGNAE GRLFEMAPVY LAKELPINEH
610 620 630 640 650
PHERQTLCIG AFGPEEDFFT VKGALEALAA GFGLTFDYQR ETAAWLHPGI
660 670 680 690 700
SAAVYCNGKR LGVFGKLANE INAELEIAKE QKDSQNIYLG ELDYEALMSC
710 720 730 740 750
VEGELRYKPL SPYAPVKRDL ALVCGEAVSC GEIEETIRKA SPLVSEVKLF
760 770 780 790 800
DIYRGANLGD GKKSMAFSLS LSDPKKEVSA EEVERVVKKI LGNLKFKLGI

EIR
Length:803
Mass (Da):88,156
Last modified:May 18, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB6B605BD0993F0AC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FP929046 Genomic DNA Translation: CBL02629.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CBL02629; CBL02629; FPR_24740

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
fpa:FPR_24740

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|657322.3.peg.2330

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929046 Genomic DNA Translation: CBL02629.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi657322.FPR_24740

Proteomic databases

PRIDEiD4KCR6

Genome annotation databases

EnsemblBacteriaiCBL02629; CBL02629; FPR_24740
KEGGifpa:FPR_24740
PATRICifig|657322.3.peg.2330

Phylogenomic databases

eggNOGiCOG0072, Bacteria
COG0073, Bacteria
HOGENOMiCLU_016891_0_0_9
KOiK01890

Family and domain databases

CDDicd00769, PheRS_beta_core, 1 hit
cd02796, tRNA_bind_bactPheRS, 1 hit
Gene3Di3.30.70.380, 1 hit
3.50.40.10, 1 hit
HAMAPiMF_00283, Phe_tRNA_synth_beta1, 1 hit
InterProiView protein in InterPro
IPR005146, B3/B4_tRNA-bd
IPR009061, DNA-bd_dom_put_sf
IPR005121, Fdx_antiC-bd
IPR036690, Fdx_antiC-bd_sf
IPR012340, NA-bd_OB-fold
IPR004532, Phe-tRNA-ligase_IIc_bsu
IPR020825, Phe-tRNA_synthase_B3/B4
IPR041616, PheRS_beta_core
IPR002547, tRNA-bd_dom
IPR033714, tRNA_bind_bactPheRS
IPR005147, tRNA_synthase_B5-dom
PfamiView protein in Pfam
PF03483, B3_4, 1 hit
PF03484, B5, 1 hit
PF03147, FDX-ACB, 1 hit
PF01588, tRNA_bind, 1 hit
PF17759, tRNA_synthFbeta, 1 hit
SMARTiView protein in SMART
SM00873, B3_4, 1 hit
SM00874, B5, 1 hit
SM00896, FDX-ACB, 1 hit
SUPFAMiSSF46955, SSF46955, 1 hit
SSF50249, SSF50249, 1 hit
SSF54991, SSF54991, 1 hit
TIGRFAMsiTIGR00472, pheT_bact, 1 hit
PROSITEiView protein in PROSITE
PS51483, B5, 1 hit
PS51447, FDX_ACB, 1 hit
PS50886, TRBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4KCR6_9FIRM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4KCR6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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