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Entry version 44 (10 Apr 2019)
Sequence version 1 (18 May 2010)
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Protein

Chondroitin sulfate ABC lyase

Gene

AL1_08220

Organism
Alistipes shahii WAL 8301
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Broad-specificity glycosaminoglycan lyase.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi32CalciumUniRule annotation1
Metal bindingi34CalciumUniRule annotation1
Metal bindingi60Calcium; via carbonyl oxygenUniRule annotation1
Metal bindingi170CalciumUniRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei181Important for catalytic activity against all substratesUniRule annotation1
Sitei351Important for catalytic activity against dermatan sulfate substrateUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei352Proton acceptorUniRule annotation1
Active sitei461Proton acceptorUniRule annotation1
Active sitei468Proton donorUniRule annotation1
Sitei522Transition state stabilizerUniRule annotation1
Sitei617Important for catalytic activity against all substratesUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processCarbohydrate metabolismUniRule annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ASHA717959:AL1_RS03860-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
PL8 Polysaccharide Lyase Family 8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chondroitin sulfate ABC lyaseUniRule annotation
Alternative name(s):
Chondroitin ABC eliminaseUniRule annotation
Chondroitin ABC lyaseUniRule annotation
Chondroitinase ABCUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AL1_08220Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAlistipes shahii WAL 8301Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri717959 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesRikenellaceaeAlistipes

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500305930420 – 1010Chondroitin sulfate ABC lyaseSequence analysisAdd BLAST991

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 191Lyase_NInterPro annotationAdd BLAST164
Domaini215 – 565Lyase_catalytInterPro annotationAdd BLAST351
Domaini586 – 849Lyase_8InterPro annotationAdd BLAST264
Domaini866 – 925Lyase_8_CInterPro annotationAdd BLAST60

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polysaccharide lyase 8 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105TCD Bacteria
ENOG410Y18H LUCA

KEGG Orthology (KO)

More...
KOi
K08961

Database of Orthologous Groups

More...
OrthoDBi
941406at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.10.100, 1 hit
2.60.220.10, 1 hit
2.70.98.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039174 Chondroitin_ABC_lyase
IPR008929 Chondroitin_lyas
IPR024200 Chondroitinase_ABC_I
IPR011013 Gal_mutarotase_sf_dom
IPR008979 Galactose-bd-like_sf
IPR014718 GH-type_carb-bd
IPR011071 Lyase_8-like_C
IPR004103 Lyase_8_C
IPR003159 Lyase_8_central_dom
IPR015177 Lyase_catalyt
IPR015176 Lyase_N

The PANTHER Classification System

More...
PANTHERi
PTHR37322 PTHR37322, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02278 Lyase_8, 1 hit
PF02884 Lyase_8_C, 1 hit
PF09093 Lyase_catalyt, 1 hit
PF09092 Lyase_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF034515 Chondroitinase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48230 SSF48230, 1 hit
SSF49785 SSF49785, 1 hit
SSF49863 SSF49863, 1 hit
SSF74650 SSF74650, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D4IKB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYKLLFLAAA SVWSWAAPAQ SVREVADARI LSFEESAAPF TASEGSSLSV
60 70 80 90 100
SGDHYKHGAH ALRWQWSRAG ARVRIESPVG YLSENPNPRE TSVSTFVFWV
110 120 130 140 150
YAPKALDGKL RFEFRKEGRT CAWFDYGLEF TGWRGAWVAF DRDMQGRPEE
160 170 180 190 200
GMDELVVTAE GVERGELYFD HLILSSFQDV RHHTADFQAP FINAATTSHW
210 220 230 240 250
LTLLQSWRNP MPALPAAVGE GERRDMATVE RRLRELLLEG RKPMAMKTLR
260 270 280 290 300
KRFDAYGIAE NPDGTLRGKP IWFVRYAETY INLGHPDVGK LFNDNGQTLR
310 320 330 340 350
KYNDFLFQVA VAHDAAADAA ERAELERMYV LLTRHLLDQG FAAGSAQGTL
360 370 380 390 400
HHLGYSMRNF YTAPVIMRDV LRRAGLEHDV QQAMEWFSGV GEVKLPPAEP
410 420 430 440 450
GMDIDAFNTS LVGRLASIVM LPDTPVKAAW LEAFSRWVDN GYKVTEGTGP
460 470 480 490 500
CFKSDGTVFH HRRHYPAYAV DGFSGGAVNA VWLLSKTQFA VSAESHAVLK
510 520 530 540 550
RALLEMRFYC NLRSFPLALS GRHPDGRGEL VPWHYARLAV AGTPDGRGEI
560 570 580 590 600
DPELAAAYLR VAKGKDAYTR LFAEKGFAPE PSPAGNRVYG YNASVSHRRA
610 620 630 640 650
DWLVTVAGHS RYLWSAEIYQ GANHYGRYLT HGSMQLLADG DPVSAFGSGF
660 670 680 690 700
RQEGWDWRHI PGTTALEIPM ERMKADIRNV DTASGYEEML LSDEAFAGGV
710 720 730 740 750
SHRGRDGVFA MELHEHDKYN GSLRARKSWF FFDNRIVCMG SDIENKAEGG
760 770 780 790 800
VHTTLFQNFL ADAADPLVVN GEAVTQFPYR AELAGGAVLR DNLRNAYFVP
810 820 830 840 850
KGRVVVSKSL QRSLDEETDA PTQNNFATAW IDHGSGSVSG GGYEYMLAVH
860 870 880 890 900
ASDEEAARYA RELPYEVLRR DASAHILRDR PSGITGYALF AAGKVGEGLL
910 920 930 940 950
ESVSLPSLVM IGGDGEGLTV SAADPDLRFY EGPSDEVFDA DGRRAERSVY
960 970 980 990 1000
SRKWIDNPSG ESQLEVVIRG RWQSADDRPE CRIEPAGENT ALIFTCREGA
1010
TREVNLIEMK
Length:1,010
Mass (Da):112,338
Last modified:May 18, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F05F3D78C2D4A4A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FP929032 Genomic DNA Translation: CBK63377.1

NCBI Reference Sequences

More...
RefSeqi
WP_015546312.1, NC_021030.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CBK63377; CBK63377; AL1_08220

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ash:AL1_08220

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|717959.3.peg.2413

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929032 Genomic DNA Translation: CBK63377.1
RefSeqiWP_015546312.1, NC_021030.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

CAZyiPL8 Polysaccharide Lyase Family 8

Genome annotation databases

EnsemblBacteriaiCBK63377; CBK63377; AL1_08220
KEGGiash:AL1_08220
PATRICifig|717959.3.peg.2413

Phylogenomic databases

eggNOGiENOG4105TCD Bacteria
ENOG410Y18H LUCA
KOiK08961
OrthoDBi941406at2

Enzyme and pathway databases

BioCyciASHA717959:AL1_RS03860-MONOMER

Family and domain databases

Gene3Di1.50.10.100, 1 hit
2.60.220.10, 1 hit
2.70.98.10, 1 hit
InterProiView protein in InterPro
IPR039174 Chondroitin_ABC_lyase
IPR008929 Chondroitin_lyas
IPR024200 Chondroitinase_ABC_I
IPR011013 Gal_mutarotase_sf_dom
IPR008979 Galactose-bd-like_sf
IPR014718 GH-type_carb-bd
IPR011071 Lyase_8-like_C
IPR004103 Lyase_8_C
IPR003159 Lyase_8_central_dom
IPR015177 Lyase_catalyt
IPR015176 Lyase_N
PANTHERiPTHR37322 PTHR37322, 1 hit
PfamiView protein in Pfam
PF02278 Lyase_8, 1 hit
PF02884 Lyase_8_C, 1 hit
PF09093 Lyase_catalyt, 1 hit
PF09092 Lyase_N, 1 hit
PIRSFiPIRSF034515 Chondroitinase, 1 hit
SUPFAMiSSF48230 SSF48230, 1 hit
SSF49785 SSF49785, 1 hit
SSF49863 SSF49863, 1 hit
SSF74650 SSF74650, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD4IKB5_9BACT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D4IKB5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: April 10, 2019
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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